OFP4_ARATH
ID OFP4_ARATH Reviewed; 315 AA.
AC F4HNU8; Q9M9Z6;
DT 09-JUL-2014, integrated into UniProtKB/Swiss-Prot.
DT 28-JUN-2011, sequence version 1.
DT 03-AUG-2022, entry version 66.
DE RecName: Full=Transcription repressor OFP4;
DE AltName: Full=Ovate family protein 4;
DE Short=AtOFP4;
GN Name=OFP4; OrderedLocusNames=At1g06920; ORFNames=F4H5.2;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP FUNCTION, AND INTERACTION WITH BLH1; BLH2; BLH3; BLH6; BLH10; KNAT1; KNAT3;
RP KNAT4; KNAT5; KNAT6 AND KNAT7.
RX PubMed=15781858; DOI=10.1073/pnas.0501181102;
RA Hackbusch J., Richter K., Muller J., Salamini F., Uhrig J.F.;
RT "A central role of Arabidopsis thaliana ovate family proteins in networking
RT and subcellular localization of 3-aa loop extension homeodomain proteins.";
RL Proc. Natl. Acad. Sci. U.S.A. 102:4908-4912(2005).
RN [4]
RP FUNCTION, INTERACTION WITH KNAT7, SUBCELLULAR LOCATION, TISSUE SPECIFICITY,
RP AND DISRUPTION PHENOTYPE.
RX PubMed=21457372; DOI=10.1111/j.1365-313x.2011.04595.x;
RA Li E., Wang S., Liu Y., Chen J.G., Douglas C.J.;
RT "OVATE FAMILY PROTEIN4 (OFP4) interaction with KNAT7 regulates secondary
RT cell wall formation in Arabidopsis thaliana.";
RL Plant J. 67:328-341(2011).
RN [5]
RP FUNCTION, TISSUE SPECIFICITY, GENE FAMILY, AND DISRUPTION PHENOTYPE.
RX PubMed=21886836; DOI=10.1371/journal.pone.0023896;
RA Wang S., Chang Y., Guo J., Zeng Q., Ellis B.E., Chen J.G.;
RT "Arabidopsis ovate family proteins, a novel transcriptional repressor
RT family, control multiple aspects of plant growth and development.";
RL PLoS ONE 6:E23896-E23896(2011).
CC -!- FUNCTION: Transcriptional repressor that regulates multiple aspects of
CC plant growth and development through the regulation of BEL1-LIKE (BLH)
CC and KNOX TALE (KNAT) homeodomain transcription factors. Forms a
CC transcription repression complex with KNAT7 which regulates secondary
CC cell wall formation. {ECO:0000269|PubMed:15781858,
CC ECO:0000269|PubMed:21457372, ECO:0000269|PubMed:21886836}.
CC -!- SUBUNIT: Interacts with BLH1, BLH2, BLH3, BLH6, BLH10, KNAT1, KNAT3,
CC KNAT4, KNAT5, KNAT6 and KNAT7. {ECO:0000269|PubMed:15781858,
CC ECO:0000269|PubMed:21457372}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expressed in root vascular cylinder, root tips,
CC xylem of stems, flower buds and siliques. {ECO:0000269|PubMed:21457372,
CC ECO:0000269|PubMed:21886836}.
CC -!- DISRUPTION PHENOTYPE: Moderate irregular xylem, but normal plant
CC morphology. {ECO:0000269|PubMed:21457372, ECO:0000269|PubMed:21886836}.
CC -!- MISCELLANEOUS: Plants over-expressing OFP4 show kidney-shaped
CC cotyledons, round and curled leaves, small rosette size, late
CC flowering, reduced fertilization and round seeds.
CC {ECO:0000305|PubMed:21886836}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAF63133.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AC011001; AAF63133.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002684; AEE28053.1; -; Genomic_DNA.
DR PIR; A86204; A86204.
DR RefSeq; NP_172174.1; NM_100566.2.
DR AlphaFoldDB; F4HNU8; -.
DR BioGRID; 22443; 16.
DR IntAct; F4HNU8; 16.
DR STRING; 3702.AT1G06920.1; -.
DR iPTMnet; F4HNU8; -.
DR PaxDb; F4HNU8; -.
DR PRIDE; F4HNU8; -.
DR EnsemblPlants; AT1G06920.1; AT1G06920.1; AT1G06920.
DR GeneID; 837202; -.
DR Gramene; AT1G06920.1; AT1G06920.1; AT1G06920.
DR KEGG; ath:AT1G06920; -.
DR Araport; AT1G06920; -.
DR TAIR; locus:2033060; AT1G06920.
DR eggNOG; ENOG502RTS2; Eukaryota.
DR HOGENOM; CLU_036558_0_0_1; -.
DR InParanoid; F4HNU8; -.
DR OMA; LPRYSHY; -.
DR OrthoDB; 1209787at2759; -.
DR PRO; PR:F4HNU8; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; F4HNU8; baseline and differential.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IDA:TAIR.
DR GO; GO:2000652; P:regulation of secondary cell wall biogenesis; IMP:TAIR.
DR InterPro; IPR025830; DNA_bnd_dom_ovate.
DR InterPro; IPR038933; Ovate.
DR InterPro; IPR006458; Ovate_C.
DR PANTHER; PTHR33057; PTHR33057; 1.
DR Pfam; PF13724; DNA_binding_2; 1.
DR Pfam; PF04844; Ovate; 1.
DR TIGRFAMs; TIGR01568; A_thal_3678; 1.
DR PROSITE; PS51754; OVATE; 1.
PE 1: Evidence at protein level;
KW Nucleus; Reference proteome; Repressor; Transcription;
KW Transcription regulation.
FT CHAIN 1..315
FT /note="Transcription repressor OFP4"
FT /id="PRO_0000429673"
FT DOMAIN 247..306
FT /note="OVATE"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01090"
FT REGION 27..54
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 159..238
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 159..197
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 212..228
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 315 AA; 36463 MW; 459D8773C12A7BA9 CRC64;
MRNYKLRLSV MSPSEWFHKL KNMTKPRKKH SLPLYSINTT KKRKPSSESK SLPYSSTSYF
FNRSRSRTSF ESRILQISPR NSLHNIQSKR KTVYKPSPPS SSIVSAGFNK TFHQSHDSLS
ASSNLKVISS EDDIIIDMNN RDFKKKTFKE ITKFDSTEKA CRASNRTKET HIPHHLSVKV
SKEKEDEEED ACRTKKKHQK TLVSSGRRSS AKSPRIKLRA RSPRIQVSPR RSKSRSQNKQ
ILDSFAVIKS SIDPSKDFRE SMVEMIAENN IRTSNDMEDL LVCYLTLNPK EYHDLIIKVF
VQVWLEVINS TFASK
