OFT10_ARATH
ID OFT10_ARATH Reviewed; 460 AA.
AC Q8LNP3; A0A1P8ANY0;
DT 25-OCT-2017, integrated into UniProtKB/Swiss-Prot.
DT 25-OCT-2017, sequence version 2.
DT 03-AUG-2022, entry version 118.
DE RecName: Full=O-fucosyltransferase 10 {ECO:0000305};
DE Short=O-FucT-10 {ECO:0000305};
DE EC=2.4.1.- {ECO:0000305};
DE AltName: Full=O-fucosyltransferase family protein {ECO:0000312|EMBL:ARJ31410.1};
GN Name=OFUT10 {ECO:0000305};
GN OrderedLocusNames=At1g38065 {ECO:0000312|Araport:AT1G38065};
GN ORFNames=T18N24.40 {ECO:0000312|EMBL:AAM94943.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC STRAIN=cv. Columbia;
RA Zeng W., Gluza P., Heazlewood J.;
RT "Arabidopsis glycosyltransferases: an update.";
RL Submitted (APR-2017) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP GENE FAMILY, AND REVIEW.
RX PubMed=22629278; DOI=10.3389/fpls.2012.00059;
RA Hansen S.F., Harholt J., Oikawa A., Scheller H.V.;
RT "Plant glycosyltransferases beyond CAZy: a perspective on DUF families.";
RL Front. Plant Sci. 3:59-59(2012).
RN [5]
RP GENE FAMILY.
RX PubMed=22916179; DOI=10.1371/journal.pone.0042914;
RA Neumetzler L., Humphrey T., Lumba S., Snyder S., Yeats T.H., Usadel B.,
RA Vasilevski A., Patel J., Rose J.K., Persson S., Bonetta D.;
RT "The FRIABLE1 gene product affects cell adhesion in Arabidopsis.";
RL PLoS ONE 7:E42914-E42914(2012).
RN [6]
RP GENE FAMILY.
RX PubMed=23272088; DOI=10.1371/journal.pone.0051129;
RA Voxeur A., Andre A., Breton C., Lerouge P.;
RT "Identification of putative rhamnogalacturonan-II specific
RT glycosyltransferases in Arabidopsis using a combination of bioinformatics
RT approaches.";
RL PLoS ONE 7:E51129-E51129(2012).
RN [7]
RP GENE FAMILY.
RX PubMed=22966747; DOI=10.1111/tpj.12019;
RA Wang Y., Mortimer J.C., Davis J., Dupree P., Keegstra K.;
RT "Identification of an additional protein involved in mannan biosynthesis.";
RL Plant J. 73:105-117(2013).
RN [8]
RP WEB RESOURCE.
RX PubMed=24905498; DOI=10.1111/tpj.12577;
RA Lao J., Oikawa A., Bromley J.R., McInerney P., Suttangkakul A.,
RA Smith-Moritz A.M., Plahar H., Chiu T.-Y., Gonzalez Fernandez-Nino S.M.G.,
RA Ebert B., Yang F., Christiansen K.M., Hansen S.F., Stonebloom S.,
RA Adams P.D., Ronald P.C., Hillson N.J., Hadi M.Z., Vega-Sanchez M.E.,
RA Loque D., Scheller H.V., Heazlewood J.L.;
RT "The plant glycosyltransferase clone collection for functional genomics.";
RL Plant J. 79:517-529(2014).
CC -!- PATHWAY: Glycan metabolism. {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8LNP3-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8LNP3-2; Sequence=VSP_059168;
CC -!- SIMILARITY: Belongs to the glycosyltransferase GT106 family.
CC {ECO:0000305}.
CC -!- CAUTION: Lacks the transmembrane domain, which is one of the conserved
CC feature of the family. {ECO:0000305}.
CC -!- WEB RESOURCE: Name=The Arabidopsis GT Collection;
CC URL="http://gt.jbei.org/arabidopsis.html";
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DR EMBL; KY906046; ARJ31410.1; -; mRNA.
DR EMBL; AC074111; AAM94943.1; -; Genomic_DNA.
DR EMBL; CP002684; ANM58355.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE31899.1; -; Genomic_DNA.
DR RefSeq; NP_001320798.1; NM_001333192.1. [Q8LNP3-1]
DR RefSeq; NP_849755.1; NM_179424.2. [Q8LNP3-2]
DR AlphaFoldDB; Q8LNP3; -.
DR PaxDb; Q8LNP3; -.
DR EnsemblPlants; AT1G38065.1; AT1G38065.1; AT1G38065. [Q8LNP3-2]
DR EnsemblPlants; AT1G38065.2; AT1G38065.2; AT1G38065. [Q8LNP3-1]
DR GeneID; 840651; -.
DR Gramene; AT1G38065.1; AT1G38065.1; AT1G38065. [Q8LNP3-2]
DR Gramene; AT1G38065.2; AT1G38065.2; AT1G38065. [Q8LNP3-1]
DR KEGG; ath:AT1G38065; -.
DR Araport; AT1G38065; -.
DR TAIR; locus:1005716710; AT1G38065.
DR HOGENOM; CLU_018420_8_1_1; -.
DR InParanoid; Q8LNP3; -.
DR OrthoDB; 427717at2759; -.
DR PhylomeDB; Q8LNP3; -.
DR PRO; PR:Q8LNP3; -.
DR Proteomes; UP000006548; Chromosome 1.
DR GO; GO:0016757; F:glycosyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0006004; P:fucose metabolic process; IEA:UniProtKB-KW.
DR CDD; cd11299; O-FucT_plant; 1.
DR InterPro; IPR024709; FucosylTrfase_pln.
DR InterPro; IPR019378; GDP-Fuc_O-FucTrfase.
DR PANTHER; PTHR31288; PTHR31288; 1.
DR Pfam; PF10250; O-FucT; 1.
DR PIRSF; PIRSF009360; UCP009360; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Carbohydrate metabolism; Fucose metabolism;
KW Glycoprotein; Glycosyltransferase; Reference proteome; Transferase.
FT CHAIN 1..460
FT /note="O-fucosyltransferase 10"
FT /id="PRO_0000442073"
FT BINDING 203..205
FT /ligand="substrate"
FT /evidence="ECO:0000250|UniProtKB:Q9H488"
FT CARBOHYD 7
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 110
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 276
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 277
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 435
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT VAR_SEQ 18
FT /note="R -> RGINVFDEIFS (in isoform 2)"
FT /id="VSP_059168"
SQ SEQUENCE 460 AA; 51804 MW; 0146C8926EFADB58 CRC64;
MPKPCPNSTV SSHFGLNRES SALAPSSGYL IVEANGGLNQ QRSAICNAVA VAGLLNAVLV
IPRFEFHAIW KDSSNFGDIY DEDHFISSLE GYVKIVRDVP DEIMTRFSYN VSSIPTIRVQ
AWATVNYYNG EVYPVLKEHG VIRITPFANR LAMSVPPYIQ LLRCIANYKA LKFSSPISTL
AEKLVDRMVE KSSATGGKYV SVHLRFEEDM VAFSCCLYEG GRAEKSEMDV IRQKSWKGKF
KRRDRVIRPD LNRVNGKCPL TPLEVGMMLR GMGFDNNTSI YLASGRIYQP EKHLAPLQEM
FPRLYTKESL ATPEELAPFQ GYSSRMAALD YTVSLLSEVF VTTQGGNFPH FLMGHRRFLF
GGHAKTVIPD KPKLVLLLQD MEMRWEVFKK EMKLMLGESD RKGVMVPRVR KINRKTSIYT
YPLPECECIF HLSSNFSNTG NILSLGALHP SSNLISSARL
