ID   ARSR1_ECOLX             Reviewed;         117 AA.
AC   P15905;
DT   01-APR-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1990, sequence version 1.
DT   25-MAY-2022, entry version 96.
DE   RecName: Full=Arsenical resistance operon repressor;
GN   Name=arsR;
OS   Escherichia coli.
OG   Plasmid R773.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=562;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2408017; DOI=10.1093/nar/18.3.619;
RA   San Francisco M.J.D., Hope C.L., Owolabi J.B., Tisa L.S., Rosen B.P.;
RT   "Identification of the metalloregulatory element of the plasmid-encoded
RT   arsenical resistance operon.";
RL   Nucleic Acids Res. 18:619-624(1990).
RN   [2]
RP   FUNCTION.
RX   PubMed=1838573; DOI=10.1111/j.1365-2958.1991.tb00779.x;
RA   Wu J., Rosen B.P.;
RT   "The ArsR protein is a trans-acting regulatory protein.";
RL   Mol. Microbiol. 5:1331-1336(1991).
RN   [3]
RP   METAL-REGULATION.
RX   PubMed=8416957; DOI=10.1016/s0021-9258(18)54113-2;
RA   Wu J., Rosen B.P.;
RT   "Metalloregulated expression of the ars operon.";
RL   J. Biol. Chem. 268:52-58(1993).
CC   -!- FUNCTION: Transcriptional repressor for the ars operon. ArsR is a
CC       trans-acting regulatory protein which controls its own expression. The
CC       repressive effect of ArsR is alleviated by oxyions of +III oxidation
CC       state of arsenic, antimony, and bismuth, as well as arsenate (As(V)).
CC       {ECO:0000269|PubMed:1838573}.
CC   -!- SUBUNIT: Binds DNA as a homodimer.
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DR   EMBL; X16045; CAA34168.1; -; Genomic_DNA.
DR   PIR; JS0448; BVECAR.
DR   RefSeq; WP_011117595.1; NZ_UDIQ01000049.1.
DR   AlphaFoldDB; P15905; -.
DR   SMR; P15905; -.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0046685; P:response to arsenic-containing substance; IEA:UniProtKB-KW.
DR   CDD; cd00090; HTH_ARSR; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR011991; ArsR-like_HTH.
DR   InterPro; IPR018334; ArsR_HTH.
DR   InterPro; IPR001845; HTH_ArsR_DNA-bd_dom.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF01022; HTH_5; 1.
DR   PRINTS; PR00778; HTHARSR.
DR   SMART; SM00418; HTH_ARSR; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS00846; HTH_ARSR_1; 1.
DR   PROSITE; PS50987; HTH_ARSR_2; 1.
PE   4: Predicted;
KW   Arsenical resistance; DNA-binding; Plasmid; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..117
FT                   /note="Arsenical resistance operon repressor"
FT                   /id="PRO_0000160611"
FT   DOMAIN          1..92
FT                   /note="HTH arsR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00340"
FT   DNA_BIND        33..52
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00340"
SQ   SEQUENCE   117 AA;  13199 MW;  1F0D10766E4FD886 CRC64;
     MLQLTPLQLF KNLSDETRLG IVLLLREMGE LCVCDLCMAL DQSQPKISRH LAMLRESGIL
     LDRKQGKWVH YRLSPHIPSW AAQIIEQAWL SQQDDVQVIA RKLASVNCSG SSKAVCI