OFT36_ARATH
ID OFT36_ARATH Reviewed; 566 AA.
AC Q9FK30; Q8L9A2;
DT 25-OCT-2017, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 124.
DE RecName: Full=O-fucosyltransferase 36 {ECO:0000305};
DE Short=O-FucT-36 {ECO:0000305};
DE EC=2.4.1.- {ECO:0000305};
DE AltName: Full=O-fucosyltransferase family protein {ECO:0000305};
GN Name=OFUT36 {ECO:0000305};
GN Synonyms=GT68 {ECO:0000303|PubMed:23272088, ECO:0000312|EMBL:AHL38584.1};
GN OrderedLocusNames=At5g50420 {ECO:0000312|Araport:AT5G50420};
GN ORFNames=MXI22.14 {ECO:0000312|EMBL:BAB09461.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND WEB RESOURCE.
RC STRAIN=cv. Columbia;
RX PubMed=24905498; DOI=10.1111/tpj.12577;
RA Lao J., Oikawa A., Bromley J.R., McInerney P., Suttangkakul A.,
RA Smith-Moritz A.M., Plahar H., Chiu T.-Y., Gonzalez Fernandez-Nino S.M.G.,
RA Ebert B., Yang F., Christiansen K.M., Hansen S.F., Stonebloom S.,
RA Adams P.D., Ronald P.C., Hillson N.J., Hadi M.Z., Vega-Sanchez M.E.,
RA Loque D., Scheller H.V., Heazlewood J.L.;
RT "The plant glycosyltransferase clone collection for functional genomics.";
RL Plant J. 79:517-529(2014).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=9734815; DOI=10.1093/dnares/5.3.203;
RA Kotani H., Nakamura Y., Sato S., Asamizu E., Kaneko T., Miyajima N.,
RA Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. VI. Sequence
RT features of the regions of 1,367,185 bp covered by 19 physically assigned
RT P1 and TAC clones.";
RL DNA Res. 5:203-216(1998).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Bautista V.R., Kim C.J., Chen H., Wu S.Y., De Los Reyes C., Ecker J.R.;
RT "Arabidopsis ORF clones.";
RL Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA Feldmann K.A.;
RT "Full-length cDNA from Arabidopsis thaliana.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP REVIEW.
RX PubMed=22629278; DOI=10.3389/fpls.2012.00059;
RA Hansen S.F., Harholt J., Oikawa A., Scheller H.V.;
RT "Plant glycosyltransferases beyond CAZy: a perspective on DUF families.";
RL Front. Plant Sci. 3:59-59(2012).
RN [7]
RP GENE FAMILY.
RX PubMed=23272088; DOI=10.1371/journal.pone.0051129;
RA Voxeur A., Andre A., Breton C., Lerouge P.;
RT "Identification of putative rhamnogalacturonan-II specific
RT glycosyltransferases in Arabidopsis using a combination of bioinformatics
RT approaches.";
RL PLoS ONE 7:E51129-E51129(2012).
RN [8]
RP GENE FAMILY.
RX PubMed=22966747; DOI=10.1111/tpj.12019;
RA Wang Y., Mortimer J.C., Davis J., Dupree P., Keegstra K.;
RT "Identification of an additional protein involved in mannan biosynthesis.";
RL Plant J. 73:105-117(2013).
CC -!- PATHWAY: Glycan metabolism. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass type II
CC membrane protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the glycosyltransferase GT106 family.
CC {ECO:0000305}.
CC -!- WEB RESOURCE: Name=The Arabidopsis GT Collection;
CC URL="http://gt.jbei.org/arabidopsis.html";
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DR EMBL; KJ138644; AHL38584.1; -; mRNA.
DR EMBL; AB012248; BAB09461.1; -; Genomic_DNA.
DR EMBL; CP002688; AED95941.1; -; Genomic_DNA.
DR EMBL; BT030356; ABO38769.1; -; mRNA.
DR EMBL; AY088561; AAM66093.1; -; mRNA.
DR RefSeq; NP_199853.1; NM_124424.4.
DR AlphaFoldDB; Q9FK30; -.
DR SMR; Q9FK30; -.
DR STRING; 3702.AT5G50420.1; -.
DR iPTMnet; Q9FK30; -.
DR PaxDb; Q9FK30; -.
DR PRIDE; Q9FK30; -.
DR ProteomicsDB; 250799; -.
DR EnsemblPlants; AT5G50420.1; AT5G50420.1; AT5G50420.
DR GeneID; 835110; -.
DR Gramene; AT5G50420.1; AT5G50420.1; AT5G50420.
DR KEGG; ath:AT5G50420; -.
DR Araport; AT5G50420; -.
DR TAIR; locus:2177492; AT5G50420.
DR eggNOG; ENOG502QS4M; Eukaryota.
DR HOGENOM; CLU_039118_0_0_1; -.
DR InParanoid; Q9FK30; -.
DR OMA; ANLYERC; -.
DR OrthoDB; 459621at2759; -.
DR PRO; PR:Q9FK30; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q9FK30; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0046922; F:peptide-O-fucosyltransferase activity; IBA:GO_Central.
DR GO; GO:0006004; P:fucose metabolic process; IEA:UniProtKB-KW.
DR InterPro; IPR019378; GDP-Fuc_O-FucTrfase.
DR InterPro; IPR045130; OFUT2-like.
DR PANTHER; PTHR13398; PTHR13398; 1.
DR Pfam; PF10250; O-FucT; 1.
PE 2: Evidence at transcript level;
KW Carbohydrate metabolism; Fucose metabolism; Glycoprotein;
KW Glycosyltransferase; Membrane; Reference proteome; Signal-anchor;
KW Transferase; Transmembrane; Transmembrane helix.
FT CHAIN 1..566
FT /note="O-fucosyltransferase 36"
FT /id="PRO_0000442098"
FT TRANSMEM 66..86
FT /note="Helical; Signal-anchor for type II membrane protein"
FT /evidence="ECO:0000305"
FT REGION 1..37
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..29
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 415..417
FT /ligand="substrate"
FT /evidence="ECO:0000250|UniProtKB:Q9Y2G5"
FT BINDING 531..532
FT /ligand="substrate"
FT /evidence="ECO:0000250|UniProtKB:Q9Y2G5"
FT CARBOHYD 93
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 129
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 138
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 179
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 190
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CONFLICT 233
FT /note="I -> L (in Ref. 5; AAM66093)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 566 AA; 64411 MW; 96523115A0F72411 CRC64;
MERNSSDDEE DHQHLIPQND TRIRHREDSV SSNATTIGGN QRSAFQIDDI LHRVQHRGKI
SLNKRYVIVF VSLIISIGLL FLLTDPRELF AANFSSFKLD PLSNRVKESE LRALYLLRQQ
QLALLSLWNG TLVNPSLNQS ENALGSSVLF EDVKSAVSKQ ISLNKEIQEV LLSPHRSSNY
SGGTDVDSVN FSYNRCRKVD QKLSDRKTVE WKPRSDKFLF AICLSGQMSN HLICLEKHMF
FAALLDRVLV IPSSKFDYQY DRVIDIERIN TCLGRNVVVA FDQFKEKAKK NHFRIDRFIC
YFSSPQLCYV DEEHIKKLKG LGISIDGKLE APWSEDIKKP SKRTVQDVQM KFKSDDDVIA
IGDVFYADME QDWVMQPGGP INHKCKTLIE PSKLILLTAQ RFIQTFLGKN FIALHFRRHG
FLKFCNAKSP SCFYPIPQAA ECIARIVERS NGAVIYLSTD AAESETSLLQ SLVVVDGKIV
PLVKRPPRNS AEKWDALLYR HGIEDDSQVD AMLDKTICAM SSVFIGASGS TFTEDILRLR
KDWGTSSTCD EYLCRGEEPN FIAEDE
