ID   ARSR2_ECOLX             Reviewed;         117 AA.
AC   P52144;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   25-MAY-2022, entry version 94.
DE   RecName: Full=Arsenical resistance operon repressor;
GN   Name=arsR;
OS   Escherichia coli.
OG   Plasmid IncN R46.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=562;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8674982; DOI=10.1111/j.1574-6968.1996.tb08195.x;
RA   Bruhn D.F., Li J., Silver S., Roberto F., Rosen B.P.;
RT   "The arsenical resistance operon of IncN plasmid R46.";
RL   FEMS Microbiol. Lett. 139:149-153(1996).
CC   -!- FUNCTION: Transcriptional repressor for the ars operon. ArsR is a
CC       trans-acting regulatory protein which controls its own expression. The
CC       repressive effect of ArsR is alleviated by oxyions of +III oxidation
CC       state of arsenic, antimony, and bismuth, as well as arsenate (As(V)).
CC   -!- SUBUNIT: Binds DNA as a homodimer.
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DR   EMBL; U38947; AAB09624.1; -; Genomic_DNA.
DR   RefSeq; WP_001114073.1; NZ_WTPU01000035.1.
DR   AlphaFoldDB; P52144; -.
DR   SMR; P52144; -.
DR   GeneID; 57431814; -.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0046685; P:response to arsenic-containing substance; IEA:UniProtKB-KW.
DR   CDD; cd00090; HTH_ARSR; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR011991; ArsR-like_HTH.
DR   InterPro; IPR018334; ArsR_HTH.
DR   InterPro; IPR001845; HTH_ArsR_DNA-bd_dom.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF01022; HTH_5; 1.
DR   PRINTS; PR00778; HTHARSR.
DR   SMART; SM00418; HTH_ARSR; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS00846; HTH_ARSR_1; 1.
DR   PROSITE; PS50987; HTH_ARSR_2; 1.
PE   4: Predicted;
KW   Arsenical resistance; DNA-binding; Plasmid; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..117
FT                   /note="Arsenical resistance operon repressor"
FT                   /id="PRO_0000160612"
FT   DOMAIN          1..92
FT                   /note="HTH arsR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00340"
FT   DNA_BIND        33..52
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00340"
SQ   SEQUENCE   117 AA;  12999 MW;  4E2D132F1F011AF6 CRC64;
     MPEIASLQLF KILSDETRLG IVLLLREMGE LCVCDLCTAL EQSQPKTSRH LAMLRESGLL
     LDRKQGKWVH YRLSPHIPSW AALVIEQAWL SQQDDVQAIA RKLASANCSG SGKAVCI