ID   ARSR2_HALSA             Reviewed;         119 AA.
AC   O52026;
DT   14-MAY-2014, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1998, sequence version 1.
DT   25-MAY-2022, entry version 118.
DE   RecName: Full=Putative arsenical resistance operon repressor ArsR2;
GN   Name=arsR2; OrderedLocusNames=VNG_5176C;
OS   Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1)
OS   (Halobacterium halobium).
OG   Plasmid pNRC100.
OC   Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Halobacteriales;
OC   Halobacteriaceae; Halobacterium.
OX   NCBI_TaxID=64091;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700922 / JCM 11081 / NRC-1;
RX   PubMed=9847077; DOI=10.1101/gr.8.11.1131;
RA   Ng W.V., Ciufo S.A., Smith T.M., Bumgarner R.E., Baskin D., Faust J.,
RA   Hall B., Loretz C., Seto J., Slagel J., Hood L., DasSarma S.;
RT   "Snapshot of a large dynamic replicon in a halophilic archaeon: megaplasmid
RT   or minichromosome?";
RL   Genome Res. 8:1131-1141(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700922 / JCM 11081 / NRC-1;
RX   PubMed=11016950; DOI=10.1073/pnas.190337797;
RA   Ng W.V., Kennedy S.P., Mahairas G.G., Berquist B., Pan M., Shukla H.D.,
RA   Lasky S.R., Baliga N.S., Thorsson V., Sbrogna J., Swartzell S., Weir D.,
RA   Hall J., Dahl T.A., Welti R., Goo Y.A., Leithauser B., Keller K., Cruz R.,
RA   Danson M.J., Hough D.W., Maddocks D.G., Jablonski P.E., Krebs M.P.,
RA   Angevine C.M., Dale H., Isenbarger T.A., Peck R.F., Pohlschroder M.,
RA   Spudich J.L., Jung K.-H., Alam M., Freitas T., Hou S., Daniels C.J.,
RA   Dennis P.P., Omer A.D., Ebhardt H., Lowe T.M., Liang P., Riley M., Hood L.,
RA   DasSarma S.;
RT   "Genome sequence of Halobacterium species NRC-1.";
RL   Proc. Natl. Acad. Sci. U.S.A. 97:12176-12181(2000).
RN   [3]
RP   INDUCTION.
RC   STRAIN=ATCC 700922 / JCM 11081 / NRC-1;
RX   PubMed=15126481; DOI=10.1128/jb.186.10.3187-3194.2004;
RA   Wang G., Kennedy S.P., Fasiludeen S., Rensing C., DasSarma S.;
RT   "Arsenic resistance in Halobacterium sp. strain NRC-1 examined by using an
RT   improved gene knockout system.";
RL   J. Bacteriol. 186:3187-3194(2004).
CC   -!- FUNCTION: Transcriptional repressor for the arsR2M operon.
CC       {ECO:0000250}.
CC   -!- INDUCTION: Constitutively expressed. {ECO:0000305|PubMed:15126481}.
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DR   EMBL; AF016485; AAC82906.1; -; Genomic_DNA.
DR   PIR; T08339; T08339.
DR   RefSeq; WP_010890459.1; NZ_BK010830.1.
DR   AlphaFoldDB; O52026; -.
DR   SMR; O52026; -.
DR   EnsemblBacteria; AAC82906; AAC82906; AAC82906.
DR   GeneID; 5954921; -.
DR   GeneID; 62888365; -.
DR   KEGG; hal:AAC82906.1; -.
DR   HOGENOM; CLU_097806_3_2_2; -.
DR   OMA; GECRNED; -.
DR   OrthoDB; 111287at2157; -.
DR   PhylomeDB; O52026; -.
DR   Proteomes; UP000000554; Plasmid pNRC100.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0046685; P:response to arsenic-containing substance; IEA:UniProtKB-KW.
DR   CDD; cd00090; HTH_ARSR; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR011991; ArsR-like_HTH.
DR   InterPro; IPR001845; HTH_ArsR_DNA-bd_dom.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PRINTS; PR00778; HTHARSR.
DR   SMART; SM00418; HTH_ARSR; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS50987; HTH_ARSR_2; 1.
PE   2: Evidence at transcript level;
KW   Arsenical resistance; DNA-binding; Plasmid; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..119
FT                   /note="Putative arsenical resistance operon repressor
FT                   ArsR2"
FT                   /id="PRO_0000429115"
FT   DOMAIN          24..119
FT                   /note="HTH arsR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00340"
FT   DNA_BIND        60..83
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00340"
SQ   SEQUENCE   119 AA;  12819 MW;  80E03B8F83167FDF CRC64;
     MVQDATADGV MDASDACCAP PGNVDSDAMA TDLQVLSAMG NDTRYELLRR IANADDGVCV
     CDLEATVGVS QSAVSQALSR LYTAGLVTRR KEGSWRYYEP TETTEVLLET LDDLRGNHE