ARSR_ECOLI
ID ARSR_ECOLI Reviewed; 117 AA.
AC P37309; Q2M7G3;
DT 01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1994, sequence version 1.
DT 03-AUG-2022, entry version 150.
DE RecName: Full=Arsenical resistance operon repressor;
GN Name=arsR; Synonyms=arsE; OrderedLocusNames=b3501, JW3468;
OS Escherichia coli (strain K12).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83333;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=K12;
RX PubMed=7721697; DOI=10.1128/jb.177.8.2050-2056.1995;
RA Diorio C., Cai J., Marmor J., Shinder R., Dubow M.S.;
RT "An Escherichia coli chromosomal ars operon homolog is functional in
RT arsenic detoxification and is conserved in Gram-negative bacteria.";
RL J. Bacteriol. 177:2050-2056(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=8041620; DOI=10.1093/nar/22.13.2576;
RA Sofia H.J., Burland V., Daniels D.L., Plunkett G. III, Blattner F.R.;
RT "Analysis of the Escherichia coli genome. V. DNA sequence of the region
RT from 76.0 to 81.5 minutes.";
RL Nucleic Acids Res. 22:2576-2586(1994).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1462(1997).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=16738553; DOI=10.1038/msb4100049;
RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT and W3110.";
RL Mol. Syst. Biol. 2:E1-E5(2006).
CC -!- FUNCTION: Transcriptional repressor for the arsEFG operon. ArsE is a
CC trans-acting regulatory protein which controls its own expression. The
CC repressive effect of ArsE is alleviated by oxyions of +III oxidation
CC state of arsenic, antimony, and bismuth, as well as arsenate (As(V))
CC (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Binds DNA as a homodimer. {ECO:0000250}.
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DR EMBL; X80057; CAA56361.1; -; Genomic_DNA.
DR EMBL; U00039; AAB18477.1; -; Genomic_DNA.
DR EMBL; U00096; AAC76526.1; -; Genomic_DNA.
DR EMBL; AP009048; BAE77793.1; -; Genomic_DNA.
DR PIR; A56269; A56269.
DR RefSeq; NP_417958.1; NC_000913.3.
DR RefSeq; WP_000008957.1; NZ_STEB01000046.1.
DR AlphaFoldDB; P37309; -.
DR SMR; P37309; -.
DR BioGRID; 4261323; 8.
DR BioGRID; 852321; 1.
DR DIP; DIP-9163N; -.
DR IntAct; P37309; 3.
DR STRING; 511145.b3501; -.
DR PaxDb; P37309; -.
DR PRIDE; P37309; -.
DR EnsemblBacteria; AAC76526; AAC76526; b3501.
DR EnsemblBacteria; BAE77793; BAE77793; BAE77793.
DR GeneID; 66672616; -.
DR GeneID; 948013; -.
DR KEGG; ecj:JW3468; -.
DR KEGG; eco:b3501; -.
DR PATRIC; fig|1411691.4.peg.3219; -.
DR EchoBASE; EB2147; -.
DR eggNOG; COG0640; Bacteria.
DR HOGENOM; CLU_097806_3_1_6; -.
DR InParanoid; P37309; -.
DR OMA; DGREHCV; -.
DR PhylomeDB; P37309; -.
DR BioCyc; EcoCyc:EG12235-MON; -.
DR BioCyc; MetaCyc:EG12235-MON; -.
DR PRO; PR:P37309; -.
DR Proteomes; UP000000318; Chromosome.
DR Proteomes; UP000000625; Chromosome.
DR GO; GO:0003677; F:DNA binding; IDA:EcoCyc.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IDA:EcoCyc.
DR GO; GO:0046685; P:response to arsenic-containing substance; IDA:EcoCyc.
DR GO; GO:0006351; P:transcription, DNA-templated; EXP:EcoCyc.
DR CDD; cd00090; HTH_ARSR; 1.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR011991; ArsR-like_HTH.
DR InterPro; IPR018334; ArsR_HTH.
DR InterPro; IPR001845; HTH_ArsR_DNA-bd_dom.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR Pfam; PF01022; HTH_5; 1.
DR PRINTS; PR00778; HTHARSR.
DR SMART; SM00418; HTH_ARSR; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR PROSITE; PS00846; HTH_ARSR_1; 1.
DR PROSITE; PS50987; HTH_ARSR_2; 1.
PE 3: Inferred from homology;
KW Arsenical resistance; DNA-binding; Reference proteome; Repressor;
KW Transcription; Transcription regulation.
FT CHAIN 1..117
FT /note="Arsenical resistance operon repressor"
FT /id="PRO_0000160613"
FT DOMAIN 1..92
FT /note="HTH arsR-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00340"
FT DNA_BIND 33..52
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00340"
SQ SEQUENCE 117 AA; 13253 MW; 35BC3F6F94BBD3DB CRC64;
MSFLLPIQLF KILADETRLG IVLLLSELGE LCVCDLCTAL DQSQPKISRH LALLRESGLL
LDRKQGKWVH YRLSPHIPAW AAKIIDEAWR CEQEKVQAIV RNLARQNCSG DSKNICS