ID   OGFD2_XENTR             Reviewed;         349 AA.
AC   Q28C22;
DT   29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   04-APR-2006, sequence version 1.
DT   03-AUG-2022, entry version 70.
DE   RecName: Full=2-oxoglutarate and iron-dependent oxygenase domain-containing protein 2;
DE            EC=1.14.11.-;
GN   Name=ogfod2; ORFNames=TEgg127j14.1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Egg;
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
CC         Evidence={ECO:0000255|PROSITE-ProRule:PRU00805};
CC       Note=Binds 1 Fe(2+) ion per subunit. {ECO:0000255|PROSITE-
CC       ProRule:PRU00805};
CC   -!- COFACTOR:
CC       Name=L-ascorbate; Xref=ChEBI:CHEBI:38290; Evidence={ECO:0000250};
CC   -!- SIMILARITY: Belongs to the OGFOD2 family. {ECO:0000305}.
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DR   EMBL; CR942500; CAJ82044.1; -; mRNA.
DR   RefSeq; NP_001039211.1; NM_001045746.1.
DR   AlphaFoldDB; Q28C22; -.
DR   SMR; Q28C22; -.
DR   PaxDb; Q28C22; -.
DR   PRIDE; Q28C22; -.
DR   GeneID; 734070; -.
DR   KEGG; xtr:734070; -.
DR   CTD; 79676; -.
DR   Xenbase; XB-GENE-5715480; ogfod2.
DR   eggNOG; KOG1971; Eukaryota.
DR   HOGENOM; CLU_045835_1_0_1; -.
DR   InParanoid; Q28C22; -.
DR   OMA; ILSNFKY; -.
DR   OrthoDB; 756511at2759; -.
DR   PhylomeDB; Q28C22; -.
DR   TreeFam; TF329650; -.
DR   Proteomes; UP000008143; Chromosome 1.
DR   Proteomes; UP000790000; Unplaced.
DR   GO; GO:0051213; F:dioxygenase activity; IEA:UniProtKB-KW.
DR   GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR   GO; GO:0031418; F:L-ascorbic acid binding; IEA:UniProtKB-KW.
DR   GO; GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; IEA:InterPro.
DR   InterPro; IPR005123; Oxoglu/Fe-dep_dioxygenase.
DR   InterPro; IPR006620; Pro_4_hyd_alph.
DR   SMART; SM00702; P4Hc; 1.
DR   PROSITE; PS51471; FE2OG_OXY; 1.
PE   2: Evidence at transcript level;
KW   Dioxygenase; Iron; Metal-binding; Oxidoreductase; Reference proteome;
KW   Vitamin C.
FT   CHAIN           1..349
FT                   /note="2-oxoglutarate and iron-dependent oxygenase domain-
FT                   containing protein 2"
FT                   /id="PRO_0000288981"
FT   DOMAIN          211..305
FT                   /note="Fe2OG dioxygenase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00805"
FT   BINDING         231
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00805"
FT   BINDING         233
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00805"
FT   BINDING         286
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00805"
FT   BINDING         296
FT                   /ligand="2-oxoglutarate"
FT                   /ligand_id="ChEBI:CHEBI:16810"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00805"
SQ   SEQUENCE   349 AA;  40210 MW;  04AB6723EA8C9B36 CRC64;
     MMTAPKPSYS CACFYTDNIF IQEFHVHVRY TGEQQFRRDY ERVLSSQGCR TSEQFRNVLE
     TIKKEVERRR KLGEESLHRR REISLHYKPL YPEVYVLQES FLAAEFLTAV KYSKSPQANV
     EGLLHHLHSI TDKRIYRLPV FIPEFCAKLV EELENFERSD LPKGRPNTMN NYGILLNELG
     FVDALTAPLC EKYIEPLTSL LFPDWGGGCL DSHRAFVVKY ALQEDLDLSC HYDNAEVTLN
     VSLGKEFTDG NLYFSDMKEV PVNERTYAEV EHITGQGILH RGQHVHGALP ISSGERWNLI
     LWMRASDVRN KCCPMCDNEP VLVKTLGDGD GFTSVREDRE QTVDICTLT