ID   ARSR_HALSA              Reviewed;         129 AA.
AC   O52029;
DT   14-MAY-2014, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1998, sequence version 1.
DT   25-MAY-2022, entry version 115.
DE   RecName: Full=Putative arsenical resistance operon repressor ArsR;
GN   Name=arsR; OrderedLocusNames=VNG_5182G;
OS   Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1)
OS   (Halobacterium halobium).
OG   Plasmid pNRC100.
OC   Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Halobacteriales;
OC   Halobacteriaceae; Halobacterium.
OX   NCBI_TaxID=64091;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700922 / JCM 11081 / NRC-1;
RX   PubMed=9847077; DOI=10.1101/gr.8.11.1131;
RA   Ng W.V., Ciufo S.A., Smith T.M., Bumgarner R.E., Baskin D., Faust J.,
RA   Hall B., Loretz C., Seto J., Slagel J., Hood L., DasSarma S.;
RT   "Snapshot of a large dynamic replicon in a halophilic archaeon: megaplasmid
RT   or minichromosome?";
RL   Genome Res. 8:1131-1141(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700922 / JCM 11081 / NRC-1;
RX   PubMed=11016950; DOI=10.1073/pnas.190337797;
RA   Ng W.V., Kennedy S.P., Mahairas G.G., Berquist B., Pan M., Shukla H.D.,
RA   Lasky S.R., Baliga N.S., Thorsson V., Sbrogna J., Swartzell S., Weir D.,
RA   Hall J., Dahl T.A., Welti R., Goo Y.A., Leithauser B., Keller K., Cruz R.,
RA   Danson M.J., Hough D.W., Maddocks D.G., Jablonski P.E., Krebs M.P.,
RA   Angevine C.M., Dale H., Isenbarger T.A., Peck R.F., Pohlschroder M.,
RA   Spudich J.L., Jung K.-H., Alam M., Freitas T., Hou S., Daniels C.J.,
RA   Dennis P.P., Omer A.D., Ebhardt H., Lowe T.M., Liang P., Riley M., Hood L.,
RA   DasSarma S.;
RT   "Genome sequence of Halobacterium species NRC-1.";
RL   Proc. Natl. Acad. Sci. U.S.A. 97:12176-12181(2000).
RN   [3]
RP   INDUCTION, AND DISRUPTION PHENOTYPE.
RC   STRAIN=ATCC 700922 / JCM 11081 / NRC-1;
RX   PubMed=15126481; DOI=10.1128/jb.186.10.3187-3194.2004;
RA   Wang G., Kennedy S.P., Fasiludeen S., Rensing C., DasSarma S.;
RT   "Arsenic resistance in Halobacterium sp. strain NRC-1 examined by using an
RT   improved gene knockout system.";
RL   J. Bacteriol. 186:3187-3194(2004).
CC   -!- FUNCTION: Transcriptional repressor for the arsADRC operon.
CC       {ECO:0000250}.
CC   -!- INDUCTION: By arsenite and antimonite. {ECO:0000269|PubMed:15126481}.
CC   -!- DISRUPTION PHENOTYPE: Deletion of the arsADRC operon results in
CC       increased sensitivity to arsenite and antimonite but not arsenate.
CC       {ECO:0000269|PubMed:15126481}.
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DR   EMBL; AF016485; AAC82909.1; -; Genomic_DNA.
DR   PIR; T08342; T08342.
DR   AlphaFoldDB; O52029; -.
DR   SMR; O52029; -.
DR   EnsemblBacteria; AAC82909; AAC82909; AAC82909.
DR   KEGG; hal:arsR; -.
DR   HOGENOM; CLU_097806_3_0_2; -.
DR   InParanoid; O52029; -.
DR   OMA; DACELLC; -.
DR   PhylomeDB; O52029; -.
DR   Proteomes; UP000000554; Plasmid pNRC100.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0046685; P:response to arsenic-containing substance; IEA:UniProtKB-KW.
DR   CDD; cd00090; HTH_ARSR; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR011991; ArsR-like_HTH.
DR   InterPro; IPR001845; HTH_ArsR_DNA-bd_dom.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF01022; HTH_5; 1.
DR   PRINTS; PR00778; HTHARSR.
DR   SMART; SM00418; HTH_ARSR; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS50987; HTH_ARSR_2; 1.
PE   2: Evidence at transcript level;
KW   Arsenical resistance; DNA-binding; Plasmid; Reference proteome; Repressor;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..129
FT                   /note="Putative arsenical resistance operon repressor ArsR"
FT                   /id="PRO_0000429114"
FT   DOMAIN          37..129
FT                   /note="HTH arsR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00340"
FT   DNA_BIND        73..96
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00340"
SQ   SEQUENCE   129 AA;  14150 MW;  D64406438B042E2A CRC64;
     MSSTERLQRY LTDERGGCGD EEVAQRLDEL EELDAAAGGP ALEADVGVLS ALANETRYKI
     IRILHIAGEE LCVCEFSPLL DVSDSAISHS LSQLTEAGLV TRRKDGKWRK YQTTMRGDAL
     LVALNGSRR