OGFR_MOUSE
ID OGFR_MOUSE Reviewed; 633 AA.
AC Q99PG2; A2ACT6; Q99L33;
DT 01-FEB-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 137.
DE RecName: Full=Opioid growth factor receptor;
DE Short=OGFr;
DE AltName: Full=Zeta-type opioid receptor;
GN Name=Ogfr;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC STRAIN=C57BL/6J;
RX PubMed=11113537; DOI=10.1016/s0169-328x(00)00232-1;
RA Zagon I.S., Verderame M.F., Zimmer W.E., McLaughlin P.J.;
RT "Molecular characterization and distribution of the opioid growth factor
RT receptor (OGFr) in mouse.";
RL Brain Res. Mol. Brain Res. 84:106-114(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-327; SER-601 AND SER-608, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Brown adipose tissue, Heart, Liver, Lung, Pancreas, Spleen,
RC and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Receptor for opioid growth factor (OGF), also known as Met-
CC enkephalin. Seems to be involved in growth regulation (By similarity).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC Note=The OGF/OGFR complex is probably translocated to the nucleus.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q99PG2-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q99PG2-2; Sequence=VSP_004061, VSP_004062;
CC -!- TISSUE SPECIFICITY: Expressed in all tissues examined, including brain,
CC heart, lung, liver, kidney and skeletal muscle.
CC -!- SIMILARITY: Belongs to the opioid growth factor receptor family.
CC {ECO:0000305}.
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DR EMBL; AF303894; AAK01353.1; -; mRNA.
DR EMBL; AL669926; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC003875; AAH03875.1; -; mRNA.
DR CCDS; CCDS17179.1; -. [Q99PG2-1]
DR RefSeq; NP_113550.3; NM_031373.3. [Q99PG2-1]
DR AlphaFoldDB; Q99PG2; -.
DR BioGRID; 215132; 2.
DR STRING; 10090.ENSMUSP00000029087; -.
DR iPTMnet; Q99PG2; -.
DR PhosphoSitePlus; Q99PG2; -.
DR EPD; Q99PG2; -.
DR jPOST; Q99PG2; -.
DR MaxQB; Q99PG2; -.
DR PaxDb; Q99PG2; -.
DR PeptideAtlas; Q99PG2; -.
DR PRIDE; Q99PG2; -.
DR ProteomicsDB; 289968; -. [Q99PG2-1]
DR ProteomicsDB; 289969; -. [Q99PG2-2]
DR Antibodypedia; 14927; 176 antibodies from 28 providers.
DR DNASU; 72075; -.
DR Ensembl; ENSMUST00000029087; ENSMUSP00000029087; ENSMUSG00000049401. [Q99PG2-1]
DR GeneID; 72075; -.
DR KEGG; mmu:72075; -.
DR UCSC; uc008ojj.2; mouse. [Q99PG2-1]
DR UCSC; uc008ojk.2; mouse. [Q99PG2-2]
DR CTD; 11054; -.
DR MGI; MGI:1919325; Ogfr.
DR VEuPathDB; HostDB:ENSMUSG00000049401; -.
DR eggNOG; ENOG502QVIF; Eukaryota.
DR GeneTree; ENSGT00390000018730; -.
DR HOGENOM; CLU_025735_1_0_1; -.
DR InParanoid; Q99PG2; -.
DR OMA; MECRETP; -.
DR OrthoDB; 1450738at2759; -.
DR PhylomeDB; Q99PG2; -.
DR TreeFam; TF331377; -.
DR BioGRID-ORCS; 72075; 2 hits in 72 CRISPR screens.
DR PRO; PR:Q99PG2; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; Q99PG2; protein.
DR Bgee; ENSMUSG00000049401; Expressed in embryonic brain and 263 other tissues.
DR Genevisible; Q99PG2; MM.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0140625; F:opioid growth factor receptor activity; IEA:InterPro.
DR GO; GO:0040008; P:regulation of growth; IEA:UniProtKB-KW.
DR InterPro; IPR006757; OGF_rcpt.
DR InterPro; IPR039574; OGFr.
DR PANTHER; PTHR14015; PTHR14015; 1.
DR Pfam; PF04664; OGFr_N; 1.
PE 1: Evidence at protein level;
KW Acetylation; Alternative splicing; Cytoplasm; Growth regulation; Nucleus;
KW Phosphoprotein; Receptor; Reference proteome; Repeat.
FT CHAIN 1..633
FT /note="Opioid growth factor receptor"
FT /id="PRO_0000058031"
FT REPEAT 467..475
FT /note="1"
FT REPEAT 476..484
FT /note="2"
FT REPEAT 485..493
FT /note="3"
FT REPEAT 494..502
FT /note="4"
FT REPEAT 503..511
FT /note="5"
FT REPEAT 512..520
FT /note="6"
FT REPEAT 521..529
FT /note="7"
FT REPEAT 530..538
FT /note="8"
FT REPEAT 539..547
FT /note="9"
FT REPEAT 548..556
FT /note="10"
FT REPEAT 557..565
FT /note="11"
FT REPEAT 566..574
FT /note="12"
FT REPEAT 575..583
FT /note="13"
FT REPEAT 584..592
FT /note="14"
FT REGION 1..44
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 287..390
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 404..633
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 467..592
FT /note="14 X approximate tandem repeats"
FT MOTIF 257..286
FT /note="Bipartite nuclear localization signal"
FT /evidence="ECO:0000255"
FT COMPBIAS 1..37
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 312..326
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 348..376
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 422..436
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 440..461
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 553..582
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 584..620
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 1
FT /note="N-acetylmethionine"
FT /evidence="ECO:0000250|UniProtKB:Q9NZT2"
FT MOD_RES 327
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 340
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9NZT2"
FT MOD_RES 361
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9NZT2"
FT MOD_RES 365
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9NZT2"
FT MOD_RES 403
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9NZT2"
FT MOD_RES 452
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9NZT2"
FT MOD_RES 601
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 608
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT VAR_SEQ 504..512
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_004061"
FT VAR_SEQ 563..589
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_004062"
FT CONFLICT 19
FT /note="E -> D (in Ref. 3; AAH03875)"
FT /evidence="ECO:0000305"
FT CONFLICT 317..318
FT /note="GR -> SW (in Ref. 3; AAH03875)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 633 AA; 70679 MW; 0B18933C0A0C891F CRC64;
MDDPECDSTW EDESEEDGED GQADDTTDED TGDDDGDAEE ARPSLFQSRM TRYRNWRAMQ
DMQRYRHNYP DLTDQDCNGD MCNLSFYKNE ICFQPNGFLI EDILQNWKDN YDLLEENHSY
IQWLFPLREP GVNWHAKPLT LKEVEAFKSS KEVRERLVRA YELMLGFYGI QLEDRNTGAV
CRAQNFQPRF HNLNSHSHNN LRITRILKSL GELGLEHYQA PLVRFFLEET LVQHKLPSVR
QSALDYFLFA VRCRHQRREL VHFAWEHFKP RREFVWGPRD KLRRFRPQTI SRPLMGLGQA
DKDEGPGDPS QEAGTQGRTC GSGRDLSGDS GTAEDLSLLS AKPQDVGTLD GDQRHEAKSP
SPKESKKRKL EGNRQEQVPG EPDPQGVSEV EKIALNLEGC ALSPTSQEPR EAEQPCLVAR
VANEVRKRRK VEEGAEGDGV ASNTQVQASA LSPTPSECPE SQKDGNGPED PKSQVGPEDP
KSQVGPEDPK SQVGPEDPKS QVGPEDPKGQ VEPEDPKGQV GPEDPKGQVG PEDPKGQVGP
EDPKSQVGPE DPKSQVEPED PKSQVEPEDP KSQVEPEDPK SQVGPEDPQS QVGPEQAASK
SLGEDPDSDT TGTSMSESEE LARIEASVEP PKP
