OGFR_RAT
ID OGFR_RAT Reviewed; 580 AA.
AC Q9QXY4;
DT 01-FEB-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 106.
DE RecName: Full=Opioid growth factor receptor;
DE Short=OGFr;
DE AltName: Full=Zeta-type opioid receptor;
GN Name=Ogfr;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Sprague-Dawley; TISSUE=Brain;
RX PubMed=10592296; DOI=10.1016/s0006-8993(99)02046-6;
RA Zagon I.S., Verderame M.F., Allen S.S., McLaughlin P.J.;
RT "Cloning, sequencing, expression and function of a cDNA encoding a receptor
RT for the opioid growth factor, [Met(5)]enkephalin.";
RL Brain Res. 849:147-154(1999).
RN [2]
RP SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND REVIEW.
RX PubMed=11890982; DOI=10.1016/s0165-0173(01)00160-6;
RA Zagon I.S., Verderame M.F., McLaughlin P.J.;
RT "The biology of the opioid growth factor receptor (OGFr).";
RL Brain Res. Brain Res. Rev. 38:351-376(2002).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-403 AND SER-548, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=22673903; DOI=10.1038/ncomms1871;
RA Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C.,
RA Olsen J.V.;
RT "Quantitative maps of protein phosphorylation sites across 14 different rat
RT organs and tissues.";
RL Nat. Commun. 3:876-876(2012).
CC -!- FUNCTION: Receptor for opioid growth factor (OGF), also known as Met-
CC enkephalin. Seems to be involved in growth regulation.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, perinuclear region
CC {ECO:0000269|PubMed:11890982}. Nucleus {ECO:0000269|PubMed:11890982}.
CC Note=The OGF/OGFR complex is probably translocated to the nucleus.
CC Colocalized with OGF in the perinuclear region.
CC -!- TISSUE SPECIFICITY: Highly expressed in 6-day old cerebellum and brain.
CC Lower expressed in adult cerebellum. The protein is detected in
CC germinal cells of the cerebellum, in neurons of the deep cerebellar
CC nuclei and in the glia in the medullary layer.
CC {ECO:0000269|PubMed:11890982}.
CC -!- SIMILARITY: Belongs to the opioid growth factor receptor family.
CC {ECO:0000305}.
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DR EMBL; AF156878; AAF25002.1; -; mRNA.
DR AlphaFoldDB; Q9QXY4; -.
DR STRING; 10116.ENSRNOP00000012612; -.
DR iPTMnet; Q9QXY4; -.
DR PhosphoSitePlus; Q9QXY4; -.
DR jPOST; Q9QXY4; -.
DR PaxDb; Q9QXY4; -.
DR PRIDE; Q9QXY4; -.
DR UCSC; RGD:69324; rat.
DR RGD; 69324; Ogfr.
DR eggNOG; ENOG502QVIF; Eukaryota.
DR InParanoid; Q9QXY4; -.
DR PhylomeDB; Q9QXY4; -.
DR PRO; PR:Q9QXY4; -.
DR Proteomes; UP000002494; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0140625; F:opioid growth factor receptor activity; IEA:InterPro.
DR GO; GO:0040008; P:regulation of growth; IEA:UniProtKB-KW.
DR InterPro; IPR006757; OGF_rcpt.
DR InterPro; IPR039574; OGFr.
DR PANTHER; PTHR14015; PTHR14015; 1.
DR Pfam; PF04664; OGFr_N; 1.
PE 1: Evidence at protein level;
KW Acetylation; Cytoplasm; Growth regulation; Nucleus; Phosphoprotein;
KW Receptor; Reference proteome; Repeat.
FT CHAIN 1..580
FT /note="Opioid growth factor receptor"
FT /id="PRO_0000058032"
FT REPEAT 467..475
FT /note="1"
FT REPEAT 476..484
FT /note="2"
FT REPEAT 485..493
FT /note="3"
FT REPEAT 494..502
FT /note="4"
FT REPEAT 503..511
FT /note="5"
FT REPEAT 512..520
FT /note="6"
FT REPEAT 521..529
FT /note="7"
FT REPEAT 530..538
FT /note="8"
FT REGION 1..44
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 285..390
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 405..580
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 467..538
FT /note="8 X approximate tandem repeats"
FT MOTIF 257..286
FT /note="Bipartite nuclear localization signal"
FT /evidence="ECO:0000255"
FT COMPBIAS 1..37
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 310..326
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 333..348
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 349..376
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 422..436
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 466..543
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 1
FT /note="N-acetylmethionine"
FT /evidence="ECO:0000250|UniProtKB:Q9NZT2"
FT MOD_RES 327
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q99PG2"
FT MOD_RES 361
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9NZT2"
FT MOD_RES 365
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9NZT2"
FT MOD_RES 403
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:22673903"
FT MOD_RES 548
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:22673903"
FT MOD_RES 555
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q99PG2"
SQ SEQUENCE 580 AA; 64728 MW; 748F722A4134115B CRC64;
MDDPDCDSTW EEESEEDGED GQADDTTDED TGDDDGDAEE ARPSLFQSRM TGYRNWRAMQ
DMQRYRHNYP DLTDQDCNGD MCNLSFYKNE ICFQPNGALI EDILQNWKDN YDLLEENHSY
IQWLFPLREP GVNWHAKPLT LKEVEAFKSS KEVRERLVRA YELMLGFYGF HLEDRGTGAV
CRAQNFQPRF HNLNSHSHNN LRITRILKSL GELGLEHYQA PLVRFFLEET LVQHKLPSVR
QSALDYFLFA VRCRHQRREL VYFAWEHFKP RREFVWGPRD KLRRFKPQTI PQPLTGPGQA
DKDEGSRDPS QEAGTQGRTC GSGRDLSGDS GTAEDPSLLN TKPSDGGTLD GNQRDEAKSL
SPKESKKRKL EGNRQEQVPG EADPQGVSEV EKIALNLEEC ALSPISQEPR EAEPPCPVAR
VANEVRKRRK VEEGAEGDGV VSNTQMQASA LPPTPSECPE AQKDGNGPED SNSQVGAEDS
KSQVGPEDPN SQVGLEDPNS QVGPEDPNSQ VGPEDPNSQV GPEDPNSQVG PEDPNSQVVG
PEQAASKSPV EDPDSDTMGT SVDESEELAR IEASAEPPKP
