ID   OGG1_METTH              Reviewed;         312 AA.
AC   O27397;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   25-MAY-2022, entry version 132.
DE   RecName: Full=Probable N-glycosylase/DNA lyase;
DE   Includes:
DE     RecName: Full=8-oxoguanine DNA glycosylase;
DE              EC=3.2.2.-;
DE   Includes:
DE     RecName: Full=DNA-(apurinic or apyrimidinic site) lyase;
DE              Short=AP lyase;
DE              EC=4.2.99.18;
GN   OrderedLocusNames=MTH_1342;
OS   Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM
OS   10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum).
OC   Archaea; Euryarchaeota; Methanomada group; Methanobacteria;
OC   Methanobacteriales; Methanobacteriaceae; Methanothermobacter.
OX   NCBI_TaxID=187420;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H;
RX   PubMed=9371463; DOI=10.1128/jb.179.22.7135-7155.1997;
RA   Smith D.R., Doucette-Stamm L.A., Deloughery C., Lee H.-M., Dubois J.,
RA   Aldredge T., Bashirzadeh R., Blakely D., Cook R., Gilbert K., Harrison D.,
RA   Hoang L., Keagle P., Lumm W., Pothier B., Qiu D., Spadafora R., Vicare R.,
RA   Wang Y., Wierzbowski J., Gibson R., Jiwani N., Caruso A., Bush D.,
RA   Safer H., Patwell D., Prabhakar S., McDougall S., Shimer G., Goyal A.,
RA   Pietrovski S., Church G.M., Daniels C.J., Mao J.-I., Rice P., Noelling J.,
RA   Reeve J.N.;
RT   "Complete genome sequence of Methanobacterium thermoautotrophicum deltaH:
RT   functional analysis and comparative genomics.";
RL   J. Bacteriol. 179:7135-7155(1997).
CC   -!- FUNCTION: DNA repair enzyme that incises DNA at 8-oxoG residues.
CC       Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-
CC       methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-lyase
CC       activity that nicks DNA 3' to the lesion (By similarity).
CC       {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-
CC         deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-
CC         dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-monophospho-
CC         2'-deoxyribonucleoside-DNA + H(+); Xref=Rhea:RHEA:66592, Rhea:RHEA-
CC         COMP:13180, Rhea:RHEA-COMP:16897, Rhea:RHEA-COMP:17067,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:136412, ChEBI:CHEBI:157695,
CC         ChEBI:CHEBI:167181; EC=4.2.99.18;
CC   -!- SIMILARITY: Belongs to the type-1 OGG1 family. {ECO:0000305}.
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DR   EMBL; AE000666; AAB85820.1; -; Genomic_DNA.
DR   PIR; E69045; E69045.
DR   RefSeq; WP_010876955.1; NC_000916.1.
DR   AlphaFoldDB; O27397; -.
DR   SMR; O27397; -.
DR   STRING; 187420.MTH_1342; -.
DR   EnsemblBacteria; AAB85820; AAB85820; MTH_1342.
DR   GeneID; 1471059; -.
DR   KEGG; mth:MTH_1342; -.
DR   HOGENOM; CLU_027543_3_0_2; -.
DR   OMA; EPYGKWK; -.
DR   Proteomes; UP000005223; Chromosome.
DR   GO; GO:0034039; F:8-oxo-7,8-dihydroguanine DNA N-glycosylase activity; IEA:InterPro.
DR   GO; GO:0140078; F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity; IEA:UniProtKB-EC.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:InterPro.
DR   GO; GO:0006284; P:base-excision repair; IEA:InterPro.
DR   GO; GO:0006289; P:nucleotide-excision repair; IEA:InterPro.
DR   CDD; cd00056; ENDO3c; 1.
DR   Gene3D; 1.10.1670.10; -; 1.
DR   InterPro; IPR011257; DNA_glycosylase.
DR   InterPro; IPR003265; HhH-GPD_domain.
DR   InterPro; IPR023170; HhH_base_excis_C.
DR   InterPro; IPR000445; HhH_motif.
DR   InterPro; IPR004577; Ogg1.
DR   InterPro; IPR012904; OGG_N.
DR   Pfam; PF00633; HHH; 1.
DR   Pfam; PF00730; HhH-GPD; 1.
DR   Pfam; PF07934; OGG_N; 1.
DR   SMART; SM00478; ENDO3c; 1.
DR   SUPFAM; SSF48150; SSF48150; 1.
DR   TIGRFAMs; TIGR00588; ogg; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair; Glycosidase; Hydrolase; Lyase;
KW   Multifunctional enzyme; Reference proteome.
FT   CHAIN           1..312
FT                   /note="Probable N-glycosylase/DNA lyase"
FT                   /id="PRO_0000058596"
FT   REGION          1..22
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        235
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   312 AA;  36052 MW;  D33B4FF497BC5A1C CRC64;
     MRIPVGDFDL EMTQRSGQTS QPPWREVEGA FRELLIIEGV PCPVEVRNEA GVLRVRPYVD
     VPQKTLREKI EYIFDLKFDI EDFYTFLEDK NLSYTLDSSR GLRLFLAKDP FECVISSIAS
     ANCSVVRWTR SIEDIRRLWG QANTFNGETF HTFPSPHVLT GVAEGSLEDL QRAEDNLPSD
     FSFNDLRSCG VGYRAPYIRE TSRILAEEMD IRRIDGMDYD DARELLLELS GVGPKVADCI
     LLYGFRKTEA FPVDVWIRRI MNHIHPGRNF NDRSMVEFAR REYGEMADYV QLYLFNHARR
     SGLLDRLRQG TG