ID   ARSR_STAAU              Reviewed;         104 AA.
AC   P30338;
DT   01-APR-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1993, sequence version 1.
DT   25-MAY-2022, entry version 89.
DE   RecName: Full=Arsenical resistance operon repressor;
GN   Name=arsR;
OS   Staphylococcus aureus.
OG   Plasmid pI258.
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=1280;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=1534328; DOI=10.1128/jb.174.11.3684-3694.1992;
RA   Ji G., Silver S.;
RT   "Regulation and expression of the arsenic resistance operon from
RT   Staphylococcus aureus plasmid pI258.";
RL   J. Bacteriol. 174:3684-3694(1992).
CC   -!- FUNCTION: Transcriptional repressor for the ars operon. ArsR is a
CC       trans-acting regulatory protein which controls its own expression. The
CC       repressive effect of ArsR is alleviated by oxyions of +III oxidation
CC       state of arsenic, antimony, and bismuth, as well as arsenate (As(V)).
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DR   EMBL; M86824; AAA25636.1; -; Genomic_DNA.
DR   PIR; B41903; B41903.
DR   RefSeq; WP_000120606.1; NZ_WKIV01000028.1.
DR   RefSeq; YP_006937609.1; NC_013319.1.
DR   RefSeq; YP_006938163.1; NC_013333.1.
DR   RefSeq; YP_006938643.1; NC_013347.1.
DR   RefSeq; YP_006938777.1; NC_013352.1.
DR   AlphaFoldDB; P30338; -.
DR   SMR; P30338; -.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0046685; P:response to arsenic-containing substance; IEA:UniProtKB-KW.
DR   CDD; cd00090; HTH_ARSR; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR011991; ArsR-like_HTH.
DR   InterPro; IPR018334; ArsR_HTH.
DR   InterPro; IPR001845; HTH_ArsR_DNA-bd_dom.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF01022; HTH_5; 1.
DR   PRINTS; PR00778; HTHARSR.
DR   SMART; SM00418; HTH_ARSR; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS00846; HTH_ARSR_1; 1.
DR   PROSITE; PS50987; HTH_ARSR_2; 1.
PE   4: Predicted;
KW   Arsenical resistance; DNA-binding; Plasmid; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..104
FT                   /note="Arsenical resistance operon repressor"
FT                   /id="PRO_0000160614"
FT   DOMAIN          1..92
FT                   /note="HTH arsR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00340"
FT   DNA_BIND        32..51
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00340"
SQ   SEQUENCE   104 AA;  11864 MW;  975664A2469CC417 CRC64;
     MSYKELSTIL KILSDSSRLE ILDLLSCGEL CACDLLEHFQ FSQPTLSHHM KSLVDNELVT
     TRKDGNKHWY QLNHAILDDI IQNLNIINTS NQRCVCKNVK SGDC