ID   ARSR_STAXY              Reviewed;         104 AA.
AC   Q01256;
DT   01-APR-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1993, sequence version 1.
DT   25-MAY-2022, entry version 80.
DE   RecName: Full=Arsenical resistance operon repressor;
GN   Name=arsR;
OS   Staphylococcus xylosus.
OG   Plasmid pSX267.
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=1288;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=DSM 20267 / Isolate C2A;
RX   PubMed=1534327; DOI=10.1128/jb.174.11.3676-3683.1992;
RA   Rosenstein R., Peschel A., Wieland B., Goetz F.;
RT   "Expression and regulation of the antimonite, arsenite, and arsenate
RT   resistance operon of Staphylococcus xylosus plasmid pSX267.";
RL   J. Bacteriol. 174:3676-3683(1992).
CC   -!- FUNCTION: Transcriptional repressor for the ars operon. ArsR is a
CC       trans-acting regulatory protein which controls its own expression. The
CC       repressive effect of ArsR is alleviated by oxyions of +III oxidation
CC       state of arsenic, antimony, and bismuth, as well as arsenate (As(V)).
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DR   EMBL; M80565; AAA27587.1; -; Genomic_DNA.
DR   PIR; A41902; A41902.
DR   AlphaFoldDB; Q01256; -.
DR   SMR; Q01256; -.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0046685; P:response to arsenic-containing substance; IEA:UniProtKB-KW.
DR   CDD; cd00090; HTH_ARSR; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR011991; ArsR-like_HTH.
DR   InterPro; IPR018334; ArsR_HTH.
DR   InterPro; IPR001845; HTH_ArsR_DNA-bd_dom.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF01022; HTH_5; 1.
DR   PRINTS; PR00778; HTHARSR.
DR   SMART; SM00418; HTH_ARSR; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS00846; HTH_ARSR_1; 1.
DR   PROSITE; PS50987; HTH_ARSR_2; 1.
PE   4: Predicted;
KW   Arsenical resistance; DNA-binding; Plasmid; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..104
FT                   /note="Arsenical resistance operon repressor"
FT                   /id="PRO_0000160615"
FT   DOMAIN          1..92
FT                   /note="HTH arsR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00340"
FT   DNA_BIND        32..51
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00340"
SQ   SEQUENCE   104 AA;  11866 MW;  17B68444B7B344A7 CRC64;
     MSYKELSTIL KVLSDPSRLE ILDLLSCGEL CACDLLEHFQ FSQPTLSHHM KSLVDNELVT
     TRKNGNKHMY QLNHEFLDYI NQNLDIINTS DQGCACKNMK SGEC