OGRL1_HUMAN
ID OGRL1_HUMAN Reviewed; 451 AA.
AC Q5TC84; Q2TAC1; Q8NEQ4; Q9H7B5;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 21-DEC-2004, sequence version 1.
DT 03-AUG-2022, entry version 120.
DE RecName: Full=Opioid growth factor receptor-like protein 1;
GN Name=OGFRL1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=14574404; DOI=10.1038/nature02055;
RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I.,
RA Rogers J., Beck S.;
RT "The DNA sequence and analysis of human chromosome 6.";
RL Nature 425:805-811(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Lung, and Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 149-451.
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [5]
RP TISSUE SPECIFICITY, AND VARIANTS PRO-47 AND LYS-396 DEL.
RX PubMed=16192744; DOI=10.1159/000088493;
RA Abd El-Aziz M.M., Patel R.J., El-Ashry M.F., Barragan I., Marcos I.,
RA Borrego S., Antinolo G., Bhattacharya S.S.;
RT "Exclusion of four candidate genes, KHDRBS2, PTP4A1, KIAA1411 and OGFRL1,
RT as causative of autosomal recessive retinitis pigmentosa.";
RL Ophthalmic Res. 38:19-23(2006).
CC -!- TISSUE SPECIFICITY: Ubiquitous. {ECO:0000269|PubMed:16192744}.
CC -!- SIMILARITY: Belongs to the opioid growth factor receptor family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAI11000.1; Type=Frameshift; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AL136164; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471051; EAW48802.1; -; Genomic_DNA.
DR EMBL; CH471051; EAW48803.1; -; Genomic_DNA.
DR EMBL; BC018688; AAH18688.1; -; mRNA.
DR EMBL; BC110999; AAI11000.1; ALT_FRAME; mRNA.
DR EMBL; AK024732; BAB14980.1; -; mRNA.
DR CCDS; CCDS34482.1; -.
DR RefSeq; NP_001311195.1; NM_001324266.1.
DR RefSeq; NP_078852.3; NM_024576.4.
DR RefSeq; XP_011534419.1; XM_011536117.2.
DR RefSeq; XP_011534420.1; XM_011536118.2.
DR RefSeq; XP_016866795.1; XM_017011306.1.
DR AlphaFoldDB; Q5TC84; -.
DR BioGRID; 122757; 2.
DR IntAct; Q5TC84; 1.
DR STRING; 9606.ENSP00000359464; -.
DR BindingDB; Q5TC84; -.
DR ChEMBL; CHEMBL3638334; -.
DR iPTMnet; Q5TC84; -.
DR PhosphoSitePlus; Q5TC84; -.
DR BioMuta; OGFRL1; -.
DR DMDM; 74746031; -.
DR EPD; Q5TC84; -.
DR jPOST; Q5TC84; -.
DR MassIVE; Q5TC84; -.
DR MaxQB; Q5TC84; -.
DR PaxDb; Q5TC84; -.
DR PeptideAtlas; Q5TC84; -.
DR PRIDE; Q5TC84; -.
DR ProteomicsDB; 64945; -.
DR Antibodypedia; 17769; 13 antibodies from 5 providers.
DR DNASU; 79627; -.
DR Ensembl; ENST00000370435.5; ENSP00000359464.3; ENSG00000119900.9.
DR GeneID; 79627; -.
DR KEGG; hsa:79627; -.
DR MANE-Select; ENST00000370435.5; ENSP00000359464.3; NM_024576.5; NP_078852.3.
DR UCSC; uc003pfx.2; human.
DR CTD; 79627; -.
DR DisGeNET; 79627; -.
DR GeneCards; OGFRL1; -.
DR HGNC; HGNC:21378; OGFRL1.
DR HPA; ENSG00000119900; Tissue enhanced (brain).
DR neXtProt; NX_Q5TC84; -.
DR OpenTargets; ENSG00000119900; -.
DR PharmGKB; PA128394713; -.
DR VEuPathDB; HostDB:ENSG00000119900; -.
DR eggNOG; ENOG502RA9J; Eukaryota.
DR GeneTree; ENSGT00390000018730; -.
DR HOGENOM; CLU_032134_3_0_1; -.
DR InParanoid; Q5TC84; -.
DR OMA; YPNYRKS; -.
DR OrthoDB; 1450738at2759; -.
DR PhylomeDB; Q5TC84; -.
DR TreeFam; TF331377; -.
DR PathwayCommons; Q5TC84; -.
DR SignaLink; Q5TC84; -.
DR BioGRID-ORCS; 79627; 2 hits in 1060 CRISPR screens.
DR ChiTaRS; OGFRL1; human.
DR GenomeRNAi; 79627; -.
DR Pharos; Q5TC84; Tchem.
DR PRO; PR:Q5TC84; -.
DR Proteomes; UP000005640; Chromosome 6.
DR RNAct; Q5TC84; protein.
DR Bgee; ENSG00000119900; Expressed in superior vestibular nucleus and 194 other tissues.
DR ExpressionAtlas; Q5TC84; baseline and differential.
DR Genevisible; Q5TC84; HS.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR GO; GO:0140625; F:opioid growth factor receptor activity; IEA:InterPro.
DR InterPro; IPR006757; OGF_rcpt.
DR InterPro; IPR039574; OGFr.
DR PANTHER; PTHR14015; PTHR14015; 1.
DR Pfam; PF04664; OGFr_N; 1.
PE 2: Evidence at transcript level;
KW Receptor; Reference proteome.
FT CHAIN 1..451
FT /note="Opioid growth factor receptor-like protein 1"
FT /id="PRO_0000314142"
FT REGION 1..89
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 308..451
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 324..340
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 360..397
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 426..445
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 47
FT /note="S -> P (in dbSNP:rs112585190)"
FT /evidence="ECO:0000269|PubMed:16192744"
FT /id="VAR_037842"
FT VARIANT 396
FT /note="Missing (in dbSNP:rs34358027)"
FT /evidence="ECO:0000269|PubMed:16192744"
FT /id="VAR_037843"
SQ SEQUENCE 451 AA; 51252 MW; D33D708BEE382696 CRC64;
MGNLLGGVSF REPTTVEDCD STWQTDSEPE PEEPGPGGGS EGPGQESEQP AQPPEQAGGR
PGASPAPDED AEAAGAEQGG DSTEATAKPK RSFYAARDLY KYRHQYPNFK DIRYQNDLSN
LRFYKNKIPF KPDGVYIEEV LSKWKGDYEK LEHNHTYIQW LFPLREQGLN FYAKELTTYE
IEEFKKTKEA IRRFLLAYKM MLEFFGIKLT DKTGNVARAV NWQERFQHLN ESQHNYLRIT
RILKSLGELG YESFKSPLVK FILHEALVEN TIPNIKQSAL EYFVYTIRDR RERRKLLRFA
QKHYTPSENF IWGPPRKEQS EGSKAQKMSS PLASSHNSQT SMHKKAKDSK NSSSAVHLNS
KTAEDKKVAP KEPVEETDRP SPEPSNEAAK PRNTEKDSNA ENMNSQPEKT VTTPTEKKES
VSPENNEEGG NDNQDNENPG NTNCHDVVLV Q
