ID   OGRL1_MOUSE             Reviewed;         464 AA.
AC   Q8VE52;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   15-JAN-2008, sequence version 2.
DT   03-AUG-2022, entry version 105.
DE   RecName: Full=Opioid growth factor receptor-like protein 1;
GN   Name=Ogfrl1;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 186-464.
RC   STRAIN=FVB/N; TISSUE=Mammary tumor;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Brain;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
CC   -!- SIMILARITY: Belongs to the opioid growth factor receptor family.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH19747.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AC165368; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC019747; AAH19747.1; ALT_INIT; mRNA.
DR   CCDS; CCDS35526.1; -.
DR   RefSeq; NP_001074548.1; NM_001081079.1.
DR   AlphaFoldDB; Q8VE52; -.
DR   STRING; 10090.ENSMUSP00000027343; -.
DR   iPTMnet; Q8VE52; -.
DR   PhosphoSitePlus; Q8VE52; -.
DR   MaxQB; Q8VE52; -.
DR   PaxDb; Q8VE52; -.
DR   PeptideAtlas; Q8VE52; -.
DR   PRIDE; Q8VE52; -.
DR   ProteomicsDB; 294167; -.
DR   Antibodypedia; 17769; 13 antibodies from 5 providers.
DR   Ensembl; ENSMUST00000027343; ENSMUSP00000027343; ENSMUSG00000026158.
DR   GeneID; 70155; -.
DR   KEGG; mmu:70155; -.
DR   UCSC; uc007amb.1; mouse.
DR   CTD; 79627; -.
DR   MGI; MGI:1917405; Ogfrl1.
DR   VEuPathDB; HostDB:ENSMUSG00000026158; -.
DR   eggNOG; ENOG502RA9J; Eukaryota.
DR   GeneTree; ENSGT00390000018730; -.
DR   HOGENOM; CLU_032134_3_0_1; -.
DR   InParanoid; Q8VE52; -.
DR   OMA; YPNYRKS; -.
DR   OrthoDB; 1450738at2759; -.
DR   PhylomeDB; Q8VE52; -.
DR   TreeFam; TF331377; -.
DR   BioGRID-ORCS; 70155; 3 hits in 70 CRISPR screens.
DR   ChiTaRS; Ogfrl1; mouse.
DR   PRO; PR:Q8VE52; -.
DR   Proteomes; UP000000589; Chromosome 1.
DR   RNAct; Q8VE52; protein.
DR   Bgee; ENSMUSG00000026158; Expressed in medial dorsal nucleus of thalamus and 248 other tissues.
DR   ExpressionAtlas; Q8VE52; baseline and differential.
DR   Genevisible; Q8VE52; MM.
DR   GO; GO:0016020; C:membrane; IEA:InterPro.
DR   GO; GO:0140625; F:opioid growth factor receptor activity; IEA:InterPro.
DR   InterPro; IPR006757; OGF_rcpt.
DR   InterPro; IPR039574; OGFr.
DR   PANTHER; PTHR14015; PTHR14015; 1.
DR   Pfam; PF04664; OGFr_N; 1.
PE   1: Evidence at protein level;
KW   Reference proteome.
FT   CHAIN           1..464
FT                   /note="Opioid growth factor receptor-like protein 1"
FT                   /id="PRO_0000314143"
FT   REGION          1..91
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          309..464
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        15..29
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        328..343
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        361..404
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        421..443
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        450..464
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   464 AA;  52268 MW;  5736423F67FB597C CRC64;
     MGNLLGGVSF REPTTVEDCD STWQTDSEPE PEQPGPAGGG EGQQHDEPEQ PKQPPERAGG
     RPRASPVPED HAEAAGAEQG GESTEGNAKP KRSFYAARDL YKYRHQYPNF KDIRYQNDLS
     NLRFYKNKIP FKPDGVYIEE VLNKWKGDYE KLEHNHTYIQ WLFPLREQGL NFYAKELTTY
     EIEEFKKTKE AIRRFLLAYK MMLEFFGIKL IDKTGNVARA GNWQERFQHL NESQHNYLRI
     TRILKSLGEL GYESFKSPLV KFILHEALVE NTIPNIKQSA LEYFVYTIRD RRERRKLLRF
     AQKHYTPSEN FIWGPPKKEL PERSKAQKTP TLPASGSNGQ TSTHKKSKDS KISPGASHVN
     SKSVEEKKGA SREPGEEADK PSPEPGSGDP KPRNTEKDSA ADQSDSPPEK TVPDTAGKGE
     CPTSSEKDGE GEDQSKDSEN PENAGCHAEV VAQQNATNPQ TSSG