ID   OHRA_BACSU              Reviewed;         141 AA.
AC   O34762;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   03-AUG-2022, entry version 114.
DE   RecName: Full=Organic hydroperoxide resistance protein OhrA;
GN   Name=ohrA; Synonyms=yklA; OrderedLocusNames=BSU13140;
OS   Bacillus subtilis (strain 168).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=224308;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=168;
RA   Devine K.M.;
RT   "Sequence of the Bacillus subtilis genome between xlyA and ykoR.";
RL   Submitted (NOV-1997) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=9384377; DOI=10.1038/36786;
RA   Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA   Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA   Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA   Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA   Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA   Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA   Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA   Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA   Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA   Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA   Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA   Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA   Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA   Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA   Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA   Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA   Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA   Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA   Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA   Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA   Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA   Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA   Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA   Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA   Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA   Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA   Yoshikawa H., Danchin A.;
RT   "The complete genome sequence of the Gram-positive bacterium Bacillus
RT   subtilis.";
RL   Nature 390:249-256(1997).
RN   [3]
RP   FUNCTION.
RC   STRAIN=168;
RX   PubMed=11418552; DOI=10.1128/jb.183.14.4134-4141.2001;
RA   Fuangthong M., Atichartpongkul S., Mongkolsuk S., Helmann J.D.;
RT   "OhrR is a repressor of ohrA, a key organic hydroperoxide resistance
RT   determinant in Bacillus subtilis.";
RL   J. Bacteriol. 183:4134-4141(2001).
CC   -!- FUNCTION: Involved in organic hydroperoxide resistance.
CC       {ECO:0000269|PubMed:11418552}.
CC   -!- INDUCTION: Strongly and specifically induced by organic peroxides.
CC       Repressed by OhrR.
CC   -!- SIMILARITY: Belongs to the OsmC/Ohr family. {ECO:0000305}.
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DR   EMBL; AJ002571; CAA05593.1; -; Genomic_DNA.
DR   EMBL; AL009126; CAB13171.1; -; Genomic_DNA.
DR   PIR; D69857; D69857.
DR   RefSeq; NP_389197.1; NC_000964.3.
DR   RefSeq; WP_003232574.1; NZ_JNCM01000035.1.
DR   AlphaFoldDB; O34762; -.
DR   SMR; O34762; -.
DR   STRING; 224308.BSU13140; -.
DR   PaxDb; O34762; -.
DR   PRIDE; O34762; -.
DR   DNASU; 939848; -.
DR   EnsemblBacteria; CAB13171; CAB13171; BSU_13140.
DR   GeneID; 939848; -.
DR   KEGG; bsu:BSU13140; -.
DR   PATRIC; fig|224308.179.peg.1426; -.
DR   eggNOG; COG1764; Bacteria.
DR   InParanoid; O34762; -.
DR   OMA; YSACFDS; -.
DR   PhylomeDB; O34762; -.
DR   BioCyc; BSUB:BSU13140-MON; -.
DR   Proteomes; UP000001570; Chromosome.
DR   GO; GO:0006979; P:response to oxidative stress; IEA:InterPro.
DR   Gene3D; 3.30.300.20; -; 1.
DR   InterPro; IPR015946; KH_dom-like_a/b.
DR   InterPro; IPR019953; OHR.
DR   InterPro; IPR003718; OsmC/Ohr_fam.
DR   InterPro; IPR036102; OsmC/Ohrsf.
DR   PANTHER; PTHR33797; PTHR33797; 1.
DR   Pfam; PF02566; OsmC; 1.
DR   SUPFAM; SSF82784; SSF82784; 1.
DR   TIGRFAMs; TIGR03561; organ_hyd_perox; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome.
FT   CHAIN           1..141
FT                   /note="Organic hydroperoxide resistance protein OhrA"
FT                   /id="PRO_0000172727"
SQ   SEQUENCE   141 AA;  14868 MW;  7F4A32D0619D2233 CRC64;
     MSQPLFTATV SAVGGREGKV ISSDRVLELD VAMPGTPRAK KLEKATNPEQ LFAAGYAACF
     DSALQLVART ERVKVETEVT ANVSLLKDEA DQGYKLGVTL QVKGEGVSAS ELEALVKKAH
     GVCPYSKATS GNIDVTLEVA E