OHRB_BACSU
ID OHRB_BACSU Reviewed; 136 AA.
AC P80242; O34747;
DT 01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 3.
DT 03-AUG-2022, entry version 129.
DE RecName: Full=Organic hydroperoxide resistance protein OhrB;
DE AltName: Full=General stress protein 17o;
DE Short=Gsp17o;
GN Name=ohrB; Synonyms=ykzA, yzzE; OrderedLocusNames=BSU13160;
OS Bacillus subtilis (strain 168).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX NCBI_TaxID=224308;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=168;
RA Devine K.M.;
RT "Sequence of the Bacillus subtilis genome between xlyA and ykoR.";
RL Submitted (NOV-1997) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=168;
RX PubMed=9384377; DOI=10.1038/36786;
RA Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA Yoshikawa H., Danchin A.;
RT "The complete genome sequence of the Gram-positive bacterium Bacillus
RT subtilis.";
RL Nature 390:249-256(1997).
RN [3]
RP PROTEIN SEQUENCE OF 2-22, AND TRANSCRIPTIONAL REGULATION.
RC STRAIN=168 / IS58;
RX PubMed=8012595; DOI=10.1099/00221287-140-4-741;
RA Voelker U., Engelmann S., Maul B., Riethdorf S., Voelker A., Schmid R.,
RA Mach H., Hecker M.;
RT "Analysis of the induction of general stress proteins of Bacillus
RT subtilis.";
RL Microbiology 140:741-752(1994).
RN [4]
RP TRANSCRIPTIONAL REGULATION.
RC STRAIN=168;
RX PubMed=9696771; DOI=10.1128/jb.180.16.4212-4218.1998;
RA Voelker U., Andersen K.K., Antelmann H., Devine K.M., Hecker M.;
RT "One of two osmC homologs in Bacillus subtilis is part of the sigmaB-
RT dependent general stress regulon.";
RL J. Bacteriol. 180:4212-4218(1998).
RN [5]
RP FUNCTION.
RC STRAIN=168;
RX PubMed=11418552; DOI=10.1128/jb.183.14.4134-4141.2001;
RA Fuangthong M., Atichartpongkul S., Mongkolsuk S., Helmann J.D.;
RT "OhrR is a repressor of ohrA, a key organic hydroperoxide resistance
RT determinant in Bacillus subtilis.";
RL J. Bacteriol. 183:4134-4141(2001).
CC -!- FUNCTION: Involved in organic hydroperoxide resistance.
CC {ECO:0000269|PubMed:11418552}.
CC -!- INDUCTION: By heat shock, salt stress, oxidative stress, glucose
CC limitation and oxygen limitation. Expression is sigma B-dependent.
CC {ECO:0000269|PubMed:8012595, ECO:0000269|PubMed:9696771}.
CC -!- SIMILARITY: Belongs to the OsmC/Ohr family. {ECO:0000305}.
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DR EMBL; AJ002571; CAA05595.1; -; Genomic_DNA.
DR EMBL; AL009126; CAB13173.1; -; Genomic_DNA.
DR PIR; F69870; F69870.
DR RefSeq; NP_389199.1; NC_000964.3.
DR RefSeq; WP_003232570.1; NZ_JNCM01000035.1.
DR PDB; 2BJO; X-ray; 2.10 A; A/B=2-136.
DR PDBsum; 2BJO; -.
DR AlphaFoldDB; P80242; -.
DR SMR; P80242; -.
DR STRING; 224308.BSU13160; -.
DR PaxDb; P80242; -.
DR PRIDE; P80242; -.
DR EnsemblBacteria; CAB13173; CAB13173; BSU_13160.
DR GeneID; 936734; -.
DR KEGG; bsu:BSU13160; -.
DR PATRIC; fig|224308.179.peg.1428; -.
DR eggNOG; COG1764; Bacteria.
DR InParanoid; P80242; -.
DR OMA; TPEKGFK; -.
DR PhylomeDB; P80242; -.
DR BioCyc; BSUB:BSU13160-MON; -.
DR EvolutionaryTrace; P80242; -.
DR Proteomes; UP000001570; Chromosome.
DR GO; GO:0006979; P:response to oxidative stress; IEA:InterPro.
DR Gene3D; 3.30.300.20; -; 1.
DR InterPro; IPR015946; KH_dom-like_a/b.
DR InterPro; IPR019953; OHR.
DR InterPro; IPR003718; OsmC/Ohr_fam.
DR InterPro; IPR036102; OsmC/Ohrsf.
DR PANTHER; PTHR33797; PTHR33797; 1.
DR Pfam; PF02566; OsmC; 1.
DR SUPFAM; SSF82784; SSF82784; 1.
DR TIGRFAMs; TIGR03561; organ_hyd_perox; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Direct protein sequencing; Reference proteome;
KW Stress response.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000269|PubMed:8012595"
FT CHAIN 2..136
FT /note="Organic hydroperoxide resistance protein OhrB"
FT /id="PRO_0000172728"
FT CONFLICT 16
FT /note="G -> A (in Ref. 3; AA sequence)"
FT /evidence="ECO:0000305"
FT STRAND 4..12
FT /evidence="ECO:0007829|PDB:2BJO"
FT HELIX 13..15
FT /evidence="ECO:0007829|PDB:2BJO"
FT STRAND 17..20
FT /evidence="ECO:0007829|PDB:2BJO"
FT STRAND 26..29
FT /evidence="ECO:0007829|PDB:2BJO"
FT TURN 32..38
FT /evidence="ECO:0007829|PDB:2BJO"
FT HELIX 44..65
FT /evidence="ECO:0007829|PDB:2BJO"
FT TURN 66..68
FT /evidence="ECO:0007829|PDB:2BJO"
FT STRAND 74..84
FT /evidence="ECO:0007829|PDB:2BJO"
FT TURN 85..88
FT /evidence="ECO:0007829|PDB:2BJO"
FT STRAND 89..99
FT /evidence="ECO:0007829|PDB:2BJO"
FT HELIX 105..118
FT /evidence="ECO:0007829|PDB:2BJO"
FT HELIX 120..125
FT /evidence="ECO:0007829|PDB:2BJO"
FT TURN 126..128
FT /evidence="ECO:0007829|PDB:2BJO"
FT STRAND 132..136
FT /evidence="ECO:0007829|PDB:2BJO"
SQ SEQUENCE 136 AA; 14600 MW; 26F8F0389A9ED2AA CRC64;
MALFTAKVTA RGGRAGHITS DDGVLDFDIV MPNAKKEGQT GTNPEQLFAA GYAACFGGAL
EHVAKEQNIE IDSEIEGQVS LMKDESDGGF KIGVTLVVNT KDLDREKAQE LVNAAHEFCP
YSKATRGNVD VKLELK
