ID   OIAC_PECAS              Reviewed;         275 AA.
AC   Q6D8V4;
DT   16-JAN-2019, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 79.
DE   RecName: Full=3-oxo-isoapionate decarboxylase {ECO:0000303|PubMed:29867142};
DE            EC=4.1.1.120 {ECO:0000269|PubMed:29867142};
GN   Name=oiaC {ECO:0000303|PubMed:29867142};
GN   OrderedLocusNames=ECA0868 {ECO:0000312|EMBL:CAG73780.1};
OS   Pectobacterium atrosepticum (strain SCRI 1043 / ATCC BAA-672) (Erwinia
OS   carotovora subsp. atroseptica).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Pectobacteriaceae; Pectobacterium.
OX   NCBI_TaxID=218491;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SCRI 1043 / ATCC BAA-672;
RX   PubMed=15263089; DOI=10.1073/pnas.0402424101;
RA   Bell K.S., Sebaihia M., Pritchard L., Holden M.T.G., Hyman L.J.,
RA   Holeva M.C., Thomson N.R., Bentley S.D., Churcher L.J.C., Mungall K.,
RA   Atkin R., Bason N., Brooks K., Chillingworth T., Clark K., Doggett J.,
RA   Fraser A., Hance Z., Hauser H., Jagels K., Moule S., Norbertczak H.,
RA   Ormond D., Price C., Quail M.A., Sanders M., Walker D., Whitehead S.,
RA   Salmond G.P.C., Birch P.R.J., Parkhill J., Toth I.K.;
RT   "Genome sequence of the enterobacterial phytopathogen Erwinia carotovora
RT   subsp. atroseptica and characterization of virulence factors.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:11105-11110(2004).
RN   [2]
RP   FUNCTION, CATALYTIC ACTIVITY, AND PATHWAY.
RX   PubMed=29867142; DOI=10.1038/s41589-018-0067-7;
RA   Carter M.S., Zhang X., Huang H., Bouvier J.T., Francisco B.S.,
RA   Vetting M.W., Al-Obaidi N., Bonanno J.B., Ghosh A., Zallot R.G.,
RA   Andersen H.M., Almo S.C., Gerlt J.A.;
RT   "Functional assignment of multiple catabolic pathways for D-apiose.";
RL   Nat. Chem. Biol. 14:696-705(2018).
CC   -!- FUNCTION: Involved in catabolism of D-apiose. Catalyzes decarboxylation
CC       of 3-oxo-isoapionate to L-erythrulose. {ECO:0000269|PubMed:29867142}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=3-oxoisoapionate + H(+) = CO2 + L-erythrulose;
CC         Xref=Rhea:RHEA:57052, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526,
CC         ChEBI:CHEBI:27913, ChEBI:CHEBI:141353; EC=4.1.1.120;
CC         Evidence={ECO:0000269|PubMed:29867142};
CC   -!- PATHWAY: Carbohydrate metabolism. {ECO:0000269|PubMed:29867142}.
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DR   EMBL; BX950851; CAG73780.1; -; Genomic_DNA.
DR   RefSeq; WP_011092471.1; NC_004547.2.
DR   AlphaFoldDB; Q6D8V4; -.
DR   SMR; Q6D8V4; -.
DR   STRING; 218491.ECA0868; -.
DR   DNASU; 2881391; -.
DR   EnsemblBacteria; CAG73780; CAG73780; ECA0868.
DR   KEGG; eca:ECA0868; -.
DR   PATRIC; fig|218491.5.peg.868; -.
DR   eggNOG; COG1082; Bacteria.
DR   HOGENOM; CLU_076042_0_0_6; -.
DR   OMA; IVEHWLP; -.
DR   OrthoDB; 1007505at2; -.
DR   BioCyc; MetaCyc:MON-20961; -.
DR   BRENDA; 4.1.1.120; 9330.
DR   Proteomes; UP000007966; Chromosome.
DR   GO; GO:0016831; F:carboxy-lyase activity; IEA:UniProtKB-KW.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:UniProtKB-KW.
DR   InterPro; IPR036237; Xyl_isomerase-like_sf.
DR   InterPro; IPR013022; Xyl_isomerase-like_TIM-brl.
DR   Pfam; PF01261; AP_endonuc_2; 1.
DR   SUPFAM; SSF51658; SSF51658; 1.
PE   1: Evidence at protein level;
KW   Carbohydrate metabolism; Decarboxylase; Lyase; Reference proteome.
FT   CHAIN           1..275
FT                   /note="3-oxo-isoapionate decarboxylase"
FT                   /id="PRO_0000446045"
SQ   SEQUENCE   275 AA;  30871 MW;  0826FF4E83A4CF40 CRC64;
     MAIGLSTYAF FWRASSRVPN PLGLAAMLEQ TAESGAGVFQ ICDYAAVEAL SPAELEKLRQ
     RAVDLGIQLE LGTRGLATDH LTRYLTMARA LDVRFIRTMF NSATHKPTQD EALALLRCVL
     PEFEQYNIQL GLETYEQVKT RDVLAVVDAI DSPALGICLD PGNCVAALEY PHEVIELTAS
     RVVNLHIKDF AFARQEGWVG FTYSGCLLGT GLLDYDALHQ TIRPNERNIN QIVEHWLPWQ
     ASAEETCRLE DAWTRHSLNY LYTRNPYANR SSHIL