OIG1_CAEEL
ID OIG1_CAEEL Reviewed; 137 AA.
AC Q9N5Z2;
DT 09-DEC-2015, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 122.
DE RecName: Full=Immunoglobulin domain-containing protein oig-1 {ECO:0000305};
DE Flags: Precursor;
GN Name=oig-1 {ECO:0000312|WormBase:C09E7.3};
GN ORFNames=C09E7.3 {ECO:0000312|WormBase:C09E7.3};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000312|Proteomes:UP000001940};
RN [1] {ECO:0000312|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000312|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2] {ECO:0000305}
RP FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE,
RP AND DISRUPTION PHENOTYPE.
RX PubMed=26387713; DOI=10.1016/j.cub.2015.08.022;
RA He S., Philbrook A., McWhirter R., Gabel C.V., Taub D.G., Carter M.H.,
RA Hanna I.M., Francis M.M., Miller D.M. III;
RT "Transcriptional control of synaptic remodeling through regulated
RT expression of an immunoglobulin superfamily protein.";
RL Curr. Biol. 25:2541-2548(2015).
RN [3] {ECO:0000305}
RP FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE,
RP AND DISRUPTION PHENOTYPE.
RX PubMed=26083757; DOI=10.1038/nature14545;
RA Howell K., White J.G., Hobert O.;
RT "Spatiotemporal control of a novel synaptic organizer molecule.";
RL Nature 523:83-87(2015).
CC -!- FUNCTION: Plays a role in neural development, where it temporally
CC regulates synapse formation in the D-type inhibitory GABAergic motor
CC neurons, dorsal D (DD) and ventral D (VD) motor neurons
CC (PubMed:26387713, PubMed:26083757). Controls the translocation of
CC postsynaptic proteins, such as the acetylcholine receptor subunit acr-
CC 12, and presynaptic proteins, such as snb-1, along nerve cords to
CC prevent premature synapse remodeling/formation (PubMed:26387713).
CC {ECO:0000269|PubMed:26083757, ECO:0000269|PubMed:26387713}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:26387713}. Secreted,
CC extracellular space {ECO:0000269|PubMed:26387713}. Cell projection,
CC dendrite {ECO:0000269|PubMed:26083757, ECO:0000269|PubMed:26387713}.
CC Cell projection, axon {ECO:0000269|PubMed:26083757}. Note=The non-
CC secreted form shows punctate expression in dendrites and is also
CC involved in synapse formation/remodeling. May also be secreted by
CC coelomocytes. {ECO:0000269|PubMed:26083757,
CC ECO:0000269|PubMed:26387713}.
CC -!- TISSUE SPECIFICITY: Expressed in DD and VD GABAergic motor neurons
CC (PubMed:26387713, PubMed:26083757). Expressed in a subset of head
CC neurons including M2 motor neurons in the pharynx (PubMed:26387713,
CC PubMed:26083757). Expressed in coelomocytes (PubMed:26387713).
CC {ECO:0000269|PubMed:26083757, ECO:0000269|PubMed:26387713}.
CC -!- DEVELOPMENTAL STAGE: Transiently expressed in DD GABAergic motor
CC neurons in embryos and during larval stage L1, with expression
CC decreasing as development proceeds (PubMed:26387713, PubMed:26083757).
CC Expressed strongly in VD GABAergic motor neurons from the end of larval
CC stage L1 onwards and in particular along the ventral nerve cord
CC (PubMed:26387713, PubMed:26083757). Specifically expressed in DD
CC GABAergic motor neurons in the dorsal and ventral nerve cords at larval
CC stages L1 and L4 (PubMed:26387713). {ECO:0000269|PubMed:26083757,
CC ECO:0000269|PubMed:26387713}.
CC -!- DISRUPTION PHENOTYPE: Viable with locomotory defects which may be
CC attributed to impaired GABAergic motor neuron function
CC (PubMed:26387713, PubMed:26083757). Hypersensitive to the drug aldicarb
CC which may be indicative of abnormal GABAergic signaling
CC (PubMed:26083757). Premature postsynaptic remodeling/formation of DD
CC GABAergic motor neurons in animals at larval stage L1 with
CC remodeling/formation occurring 8-16 hours posthatching as opposed to
CC 14-18 hours posthatching in wild-type animals (PubMed:26387713).
CC Mislocalization of postsynaptic proteins with increased dorsal to
CC ventral translocation of the acr-12 receptor in VD GABAergic motor
CC neurons at larval stages L2 and L4; leading to no acr-12 puncta in the
CC dorsal nerve and probably contributing to improper formation of
CC synaptic inputs and ectopic postsynaptic remodeling/formation of VD
CC motor neurons (PubMed:26387713, PubMed:26083757). Abnormal ectopic
CC clustering of the postsynaptic receptor unc-49 along the dorsal nerve
CC cord of DD GABAergic motor neurons (PubMed:26083757). Abnormal
CC clustering of the presynaptic proteins snb-1 and rab-3 along the dorsal
CC nerve cord of DD GABAergic motor neurons (PubMed:26083757).
CC Additionally, aberrant localization of presynaptic proteins in VD
CC GABAergic motor neurons with increased puncta for presynaptic proteins
CC including snb-1, rab-3 and syd-2 in the dorsal nerve cord, but fewer
CC puncta in the ventral nerve cord at larval stages proceeding the L1
CC larval stage, probably indicative of impaired and ectopic presynaptic
CC remodeling/formation (PubMed:26387713, PubMed:26083757).
CC {ECO:0000269|PubMed:26083757, ECO:0000269|PubMed:26387713}.
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DR EMBL; BX284603; CCD63912.1; -; Genomic_DNA.
DR RefSeq; NP_498439.1; NM_066038.1.
DR AlphaFoldDB; Q9N5Z2; -.
DR SMR; Q9N5Z2; -.
DR STRING; 6239.C09E7.3; -.
DR PaxDb; Q9N5Z2; -.
DR EnsemblMetazoa; C09E7.3.1; C09E7.3.1; WBGene00003859.
DR GeneID; 182450; -.
DR KEGG; cel:CELE_C09E7.3; -.
DR UCSC; C09E7.3; c. elegans.
DR CTD; 182450; -.
DR WormBase; C09E7.3; CE23536; WBGene00003859; oig-1.
DR eggNOG; ENOG502TI3H; Eukaryota.
DR GeneTree; ENSGT00970000196744; -.
DR HOGENOM; CLU_154798_0_0_1; -.
DR InParanoid; Q9N5Z2; -.
DR OMA; PRIVRHS; -.
DR OrthoDB; 1418131at2759; -.
DR PhylomeDB; Q9N5Z2; -.
DR PRO; PR:Q9N5Z2; -.
DR Proteomes; UP000001940; Chromosome III.
DR Bgee; WBGene00003859; Expressed in larva and 3 other tissues.
DR GO; GO:0030424; C:axon; IEA:UniProtKB-SubCell.
DR GO; GO:0030425; C:dendrite; IEA:UniProtKB-SubCell.
DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
DR Gene3D; 2.60.40.10; -; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003598; Ig_sub2.
DR Pfam; PF07679; I-set; 1.
DR SMART; SM00408; IGc2; 1.
DR SUPFAM; SSF48726; SSF48726; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
PE 2: Evidence at transcript level;
KW Cell projection; Disulfide bond; Immunoglobulin domain; Membrane;
KW Neurogenesis; Reference proteome; Secreted; Signal.
FT SIGNAL 1..23
FT /evidence="ECO:0000255"
FT CHAIN 24..137
FT /note="Immunoglobulin domain-containing protein oig-1"
FT /id="PRO_5004330308"
FT DOMAIN 41..133
FT /note="Ig-like C2-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 63..118
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
SQ SEQUENCE 137 AA; 15745 MW; 0180531BD2B99E1E CRC64;
MFSELRILRD ILLLCFLSVG INAKSSHIED LDFTDHTNGS PKISRSSYFK QDFRLGYKLK
LFCESSGNPR PQIVWYHRGV EVNPDHNRTI RFSIHGDTVS SHLEVDPTSI GDKGEYECVA
TNLKGSRVKK FLTDYQY
