ID   OIT3_BOVIN              Reviewed;         547 AA.
AC   Q29RU2;
DT   21-AUG-2007, integrated into UniProtKB/Swiss-Prot.
DT   04-APR-2006, sequence version 1.
DT   25-MAY-2022, entry version 79.
DE   RecName: Full=Oncoprotein-induced transcript 3 protein;
DE   Flags: Precursor;
GN   Name=OIT3;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Testis;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May be involved in hepatocellular function and development.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus envelope {ECO:0000250}. Note=Can be
CC       secreted into blood. {ECO:0000250}.
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DR   EMBL; BC114018; AAI14019.1; -; mRNA.
DR   RefSeq; NP_001039529.1; NM_001046064.1.
DR   AlphaFoldDB; Q29RU2; -.
DR   SMR; Q29RU2; -.
DR   STRING; 9913.ENSBTAP00000054245; -.
DR   PaxDb; Q29RU2; -.
DR   PRIDE; Q29RU2; -.
DR   GeneID; 510915; -.
DR   KEGG; bta:510915; -.
DR   CTD; 170392; -.
DR   eggNOG; ENOG502QW18; Eukaryota.
DR   InParanoid; Q29RU2; -.
DR   OrthoDB; 319810at2759; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005635; C:nuclear envelope; IEA:UniProtKB-SubCell.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   Gene3D; 2.60.40.4100; -; 1.
DR   InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR   InterPro; IPR000742; EGF-like_dom.
DR   InterPro; IPR018097; EGF_Ca-bd_CS.
DR   InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR   InterPro; IPR042235; ZP-C.
DR   InterPro; IPR001507; ZP_dom.
DR   Pfam; PF00100; Zona_pellucida; 1.
DR   PRINTS; PR00023; ZPELLUCIDA.
DR   SMART; SM00181; EGF; 3.
DR   SMART; SM00179; EGF_CA; 2.
DR   SMART; SM00241; ZP; 1.
DR   SUPFAM; SSF57184; SSF57184; 1.
DR   PROSITE; PS00010; ASX_HYDROXYL; 1.
DR   PROSITE; PS01187; EGF_CA; 1.
DR   PROSITE; PS51034; ZP_2; 1.
PE   2: Evidence at transcript level;
KW   Calcium; Disulfide bond; EGF-like domain; Glycoprotein; Nucleus;
KW   Reference proteome; Signal.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   CHAIN           20..547
FT                   /note="Oncoprotein-induced transcript 3 protein"
FT                   /id="PRO_0000298930"
FT   DOMAIN          182..222
FT                   /note="EGF-like; calcium-binding"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          267..516
FT                   /note="ZP"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00375"
FT   REGION          520..547
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        89
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        116
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        299
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        186..197
FT                   /evidence="ECO:0000250"
FT   DISULFID        193..206
FT                   /evidence="ECO:0000250"
FT   DISULFID        208..221
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   547 AA;  60550 MW;  99136132BDECBABB CRC64;
     MPQLLLLACL LIIVTRVAPR ALDPCSAYIS LNEPWRNTEH QFDESRGSPL CDNSVDGEWY
     RFTGMAGDAM PTFCIPENHC GTHAPVWLNG SHPLEGDGIV QRQACASFNG NCCLWNTTVE
     VKSCPGGYYV YRLTKPSVCF HVYCGHFYDI CDDDCHGSCL GTSECTCAPG TVLGPDRQTC
     FDENECEQNN GGCSEICVNL KNSYRCECGI GRVLRSDGKT CEDIEGCHNN NGGCSHSCLT
     SETGYQCECP RGLVLSEDNH TCQVPVFCKS NTIEVSIPRD LVGGLELFLT NTSCRGVSNG
     THVNILFSLK TCGTVVDVVN DKIVASNLVT GLPKQTPGSS GDIIIRTSKL LIPVTCEFPR
     LYTISEGYVP NLRNTPLEIM SRSHGIFPFT LEIFKDHEFE EPYREALPTL KLRDSLYFGI
     EPLVHVNGLE SLVESCFATP TSKIDEIMKY YIIQDGCVSD DSVKQYTSRD HLAKHFQVPV
     FKFVGKDHKE VFLHCRVLVC GMLDERSRCA QGCHRRVRRE ASTEGEDASG PRSQMLTGGP
     ISIDWED