OIT3_MOUSE
ID OIT3_MOUSE Reviewed; 546 AA.
AC Q8R4V5; P97806; Q811T0; Q8C9U1;
DT 21-AUG-2007, integrated into UniProtKB/Swiss-Prot.
DT 21-AUG-2007, sequence version 2.
DT 03-AUG-2022, entry version 129.
DE RecName: Full=Oncoprotein-induced transcript 3 protein;
DE AltName: Full=Liver-specific zona pellucida domain-containing protein;
DE Flags: Precursor;
GN Name=Oit3; Synonyms=Lzp;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, AND
RP DEVELOPMENTAL STAGE.
RC TISSUE=Liver;
RX PubMed=12939600; DOI=10.1053/jhep.2003.50340;
RA Xu Z.-G., Du J.-J., Zhang X., Cheng Z.-H., Ma Z.-Z., Xiao H.-S., Yu L.,
RA Wang Z.-Q., Li Y.-Y., Huo K.-K., Han Z.-G.;
RT "A novel liver-specific zona pellucida domain containing protein that is
RT expressed rarely in hepatocellular carcinoma.";
RL Hepatology 38:735-744(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION, AND TISSUE
RP SPECIFICITY.
RC TISSUE=Liver;
RX PubMed=15346761; DOI=10.1080/10425170310001652200;
RA Xu Z.-G., Du J.-J., Cui S.J., Wang Z.-Q., Huo K.-K., Li Y.-Y., Han Z.-G.;
RT "Identification of LZP gene from Mus musculus and Rattus norvegicus coding
RT for a novel liver-specific ZP domain-containing secretory protein.";
RL DNA Seq. 15:81-87(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
RA Kolanczyk M.K., Gantert M.P., Zemojtel T., Sykes D.B., Kamps M.P.,
RA Scheele J.S.;
RT "E2a-PBX1 mediates target gene expression through LDSF motif dependent and
RT independent mechanisms in 3T3 fibroblasts.";
RL Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=C57BL/6J; TISSUE=Thymus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
CC -!- FUNCTION: May be involved in hepatocellular function and development.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus envelope {ECO:0000269|PubMed:15346761}.
CC Note=Secreted into blood in a truncated form.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8R4V5-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8R4V5-2; Sequence=VSP_027484;
CC -!- TISSUE SPECIFICITY: Liver-specific. Expressed only in the hepatocytes.
CC {ECO:0000269|PubMed:12939600, ECO:0000269|PubMed:15346761}.
CC -!- DEVELOPMENTAL STAGE: Expression begins as early as 6.5 dpc and very
CC early in fetal liver (at least from 11.5 dpc). Expression level changes
CC in different developmental stages. Levels decrease to a minimal level
CC at 17.5 dpc and then increase gradually to the maximal level at about 7
CC days after birth. {ECO:0000269|PubMed:12939600}.
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DR EMBL; AF356506; AAL86587.1; -; mRNA.
DR EMBL; AY180915; AAO22058.1; -; mRNA.
DR EMBL; AF517106; AAM77901.1; -; mRNA.
DR EMBL; AF517107; AAM77638.1; -; mRNA.
DR EMBL; AK040570; BAC30631.1; -; mRNA.
DR CCDS; CCDS23865.1; -. [Q8R4V5-1]
DR RefSeq; NP_035089.1; NM_010959.2. [Q8R4V5-1]
DR AlphaFoldDB; Q8R4V5; -.
DR SMR; Q8R4V5; -.
DR STRING; 10090.ENSMUSP00000009798; -.
DR GlyGen; Q8R4V5; 3 sites.
DR PhosphoSitePlus; Q8R4V5; -.
DR MaxQB; Q8R4V5; -.
DR PaxDb; Q8R4V5; -.
DR PRIDE; Q8R4V5; -.
DR ProteomicsDB; 293499; -. [Q8R4V5-1]
DR ProteomicsDB; 293500; -. [Q8R4V5-2]
DR Antibodypedia; 29281; 114 antibodies from 19 providers.
DR DNASU; 18302; -.
DR Ensembl; ENSMUST00000009798; ENSMUSP00000009798; ENSMUSG00000009654. [Q8R4V5-1]
DR GeneID; 18302; -.
DR KEGG; mmu:18302; -.
DR UCSC; uc007fdr.1; mouse. [Q8R4V5-1]
DR CTD; 170392; -.
DR MGI; MGI:1201782; Oit3.
DR VEuPathDB; HostDB:ENSMUSG00000009654; -.
DR eggNOG; ENOG502QW18; Eukaryota.
DR GeneTree; ENSGT00940000157851; -.
DR HOGENOM; CLU_037129_2_0_1; -.
DR InParanoid; Q8R4V5; -.
DR OMA; GPQSQML; -.
DR OrthoDB; 319810at2759; -.
DR PhylomeDB; Q8R4V5; -.
DR TreeFam; TF330284; -.
DR BioGRID-ORCS; 18302; 2 hits in 73 CRISPR screens.
DR ChiTaRS; Lyz2; mouse.
DR PRO; PR:Q8R4V5; -.
DR Proteomes; UP000000589; Chromosome 10.
DR RNAct; Q8R4V5; protein.
DR Bgee; ENSMUSG00000009654; Expressed in liver and 38 other tissues.
DR Genevisible; Q8R4V5; MM.
DR GO; GO:0009986; C:cell surface; IBA:GO_Central.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0005635; C:nuclear envelope; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0005201; F:extracellular matrix structural constituent; IBA:GO_Central.
DR GO; GO:1903118; P:urate homeostasis; IMP:MGI.
DR Gene3D; 2.60.40.4100; -; 1.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR042235; ZP-C.
DR InterPro; IPR001507; ZP_dom.
DR Pfam; PF00100; Zona_pellucida; 1.
DR PRINTS; PR00023; ZPELLUCIDA.
DR SMART; SM00181; EGF; 3.
DR SMART; SM00179; EGF_CA; 2.
DR SMART; SM00241; ZP; 1.
DR PROSITE; PS51034; ZP_2; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Calcium; Disulfide bond; EGF-like domain;
KW Glycoprotein; Nucleus; Reference proteome; Signal.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT CHAIN 20..546
FT /note="Oncoprotein-induced transcript 3 protein"
FT /id="PRO_0000298932"
FT DOMAIN 182..222
FT /note="EGF-like; calcium-binding"
FT /evidence="ECO:0000255"
FT DOMAIN 261..516
FT /note="ZP"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00375"
FT CARBOHYD 89
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 116
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 299
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 186..197
FT /evidence="ECO:0000250"
FT DISULFID 193..206
FT /evidence="ECO:0000250"
FT DISULFID 208..221
FT /evidence="ECO:0000250"
FT VAR_SEQ 1..54
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|Ref.3"
FT /id="VSP_027484"
FT CONFLICT 2
FT /note="P -> S (in Ref. 2; AAO22058)"
FT /evidence="ECO:0000305"
FT CONFLICT 271
FT /note="S -> I (in Ref. 2; AAL86587)"
FT /evidence="ECO:0000305"
FT CONFLICT 446
FT /note="E -> D (in Ref. 2; AAL86587)"
FT /evidence="ECO:0000305"
FT CONFLICT 496
FT /note="R -> H (in Ref. 3; AAM77901/AAM77638)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 546 AA; 60316 MW; B669D7FBD3105295 CRC64;
MPLSLLLTCL STTVTLVSPA VLDPCSAYIS LNEPWRNTDH QFDESQNQPL CDNHMNGEWY
RFTGMAGDAM PTFCIPENHC GTHAPVWLNG SHPLEEDGIV QRQACASFKG NCCLWNATVE
VKACPRGYYV YRLARPSVCF HVYCGHFYDI CDEDCHGNCL DTTECACSPG TSLGPDGQTC
FDENECEHNN GGCSEICVNL KNSHRCACGV GRVLRSDGKT CEDIEGCHNN NGGCSHSCLG
SEEGYQCECP RGLVLSEDNH TCQVPVLCKS SAIEVSVPRE LVGGLELFLT NTSCRGVSNG
THVNIVFSLK TCGTVVDVVN DKIVASNIVT GLPKETPGSS GDIIIRTSKL LIPVTCEFPR
LYTISEGYVP NLRNAPLEIR SRNHGIFPFT LEIFKDHEFE EPYRETLPTL KLRDSLYFGI
EPLVHVNGLE SLVESCFATP TAKMDEILKY YLIQDGCVSD DSVKQYSSRD HLAKHFQAPV
FKFVGKDHKE VFLHCRVLVC GVLDERSRCA QGCHRRVRRE VGEDEDSAGL QSQTLTGGPI
AIDWED
