ID   OIT3_RAT                Reviewed;         546 AA.
AC   Q6V0K7;
DT   21-AUG-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 87.
DE   RecName: Full=Oncoprotein-induced transcript 3 protein;
DE   AltName: Full=Liver-specific zona pellucida domain-containing protein;
DE   Flags: Precursor;
GN   Name=Oit3; Synonyms=Lzp;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=15346761; DOI=10.1080/10425170310001652200;
RA   Xu Z.-G., Du J.-J., Cui S.J., Wang Z.-Q., Huo K.-K., Li Y.-Y., Han Z.-G.;
RT   "Identification of LZP gene from Mus musculus and Rattus norvegicus coding
RT   for a novel liver-specific ZP domain-containing secretory protein.";
RL   DNA Seq. 15:81-87(2004).
CC   -!- FUNCTION: May be involved in hepatocellular function and development.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus envelope {ECO:0000250}. Note=Can be
CC       secreted into blood. {ECO:0000250}.
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DR   EMBL; AY356356; AAQ55823.1; -; mRNA.
DR   EMBL; AY353853; AAQ62080.1; -; mRNA.
DR   RefSeq; NP_001001507.1; NM_001001507.1.
DR   AlphaFoldDB; Q6V0K7; -.
DR   SMR; Q6V0K7; -.
DR   STRING; 10116.ENSRNOP00000065864; -.
DR   GlyGen; Q6V0K7; 3 sites.
DR   PaxDb; Q6V0K7; -.
DR   Ensembl; ENSRNOT00000075682; ENSRNOP00000065864; ENSRNOG00000046365.
DR   GeneID; 294559; -.
DR   KEGG; rno:294559; -.
DR   CTD; 170392; -.
DR   RGD; 735082; Oit3.
DR   eggNOG; ENOG502QW18; Eukaryota.
DR   GeneTree; ENSGT00940000157851; -.
DR   InParanoid; Q6V0K7; -.
DR   OrthoDB; 319810at2759; -.
DR   PhylomeDB; Q6V0K7; -.
DR   PRO; PR:Q6V0K7; -.
DR   Proteomes; UP000002494; Chromosome 20.
DR   GO; GO:0009986; C:cell surface; IBA:GO_Central.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005635; C:nuclear envelope; IEA:UniProtKB-SubCell.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005201; F:extracellular matrix structural constituent; IBA:GO_Central.
DR   GO; GO:1903118; P:urate homeostasis; ISO:RGD.
DR   Gene3D; 2.60.40.4100; -; 1.
DR   InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR   InterPro; IPR000742; EGF-like_dom.
DR   InterPro; IPR042235; ZP-C.
DR   InterPro; IPR001507; ZP_dom.
DR   Pfam; PF00100; Zona_pellucida; 1.
DR   PRINTS; PR00023; ZPELLUCIDA.
DR   SMART; SM00181; EGF; 3.
DR   SMART; SM00179; EGF_CA; 2.
DR   SMART; SM00241; ZP; 1.
DR   PROSITE; PS51034; ZP_2; 1.
PE   2: Evidence at transcript level;
KW   Calcium; Disulfide bond; EGF-like domain; Glycoprotein; Nucleus;
KW   Reference proteome; Signal.
FT   SIGNAL          1..16
FT                   /evidence="ECO:0000255"
FT   CHAIN           17..546
FT                   /note="Oncoprotein-induced transcript 3 protein"
FT                   /id="PRO_0000298933"
FT   DOMAIN          182..222
FT                   /note="EGF-like; calcium-binding"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          261..516
FT                   /note="ZP"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00375"
FT   REGION          524..546
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        89
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        116
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        299
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        186..197
FT                   /evidence="ECO:0000250"
FT   DISULFID        193..206
FT                   /evidence="ECO:0000250"
FT   DISULFID        208..221
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   546 AA;  60179 MW;  363AEDC620006A8D CRC64;
     MPLSLLLACL FTTVTLQSPV VLDPCSAYIS LNEPWRNTDH QFDESQSQPL CDNHMDGEWY
     RFTGMAGDAM PTFCIPENHC GTHAPVWLNG SHPLEGDGIV QRQACASFKG NCCLWNTTVE
     VKACPGGYYV YRLAKPSVCF HIYCGHFYDI CDEDCHGSCL DTTECACSPG TSLGPDGQTC
     FDENECEHNN GGCSEICVNL KNSHRCACGV GRVLRSDGKT CEDIEGCHSN NGGCSHSCLG
     SEKGYQCECP RGLVLSEDNH TCQVPVLCKS SAIEVSVPRE LVGGLELFLT NTSCRGVSNG
     THVNIIFSLK TCGTVVDVVN DKIVASNLVT GLPKQTPGSS GDIIIRTSKL LIPVTCEFPR
     LYTISEGYVP NLRNAPLEIR SRNHGIFPFT LEIFKDHEFE EPYRETLPTL KLRDSLYFGI
     EPLVHVSGLE SLVESCFATP TAKVDEILKY YLIRDGCVSD DSVKQYSSRD HLAKHFQVPV
     FKFVGKDHKE VFLHCRVLVC GVLDERSRCA QGCHRRVRRE AGEDEDSAGL QSQTLTGGPI
     SIDWEE