OL139_MOUSE
ID OL139_MOUSE Reviewed; 315 AA.
AC Q60891; Q8VGR1; Q9EPY8;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 10-JAN-2006, sequence version 2.
DT 03-AUG-2022, entry version 144.
DE RecName: Full=Olfactory receptor 139;
DE AltName: Full=Odorant receptor M5;
DE AltName: Full=Olfactory receptor 1;
DE AltName: Full=Olfactory receptor 255-2;
GN Name=Olfr139; Synonyms=Mor255-2, Olfr1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=11802173; DOI=10.1038/nn800;
RA Zhang X., Firestein S.;
RT "The olfactory receptor gene superfamily of the mouse.";
RL Nat. Neurosci. 5:124-133(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=11875048; DOI=10.1093/hmg/11.5.535;
RA Young J.M., Friedman C., Williams E.M., Ross J.A., Tonnes-Priddy L.,
RA Trask B.J.;
RT "Different evolutionary processes shaped the mouse and human olfactory
RT receptor gene families.";
RL Hum. Mol. Genet. 11:535-546(2002).
RN [3]
RP ERRATUM OF PUBMED:11875048.
RA Young J.M., Friedman C., Williams E.M., Ross J.A., Tonnes-Priddy L.,
RA Trask B.J.;
RL Hum. Mol. Genet. 11:1683-1683(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-242.
RC STRAIN=129S6/SvEvTac;
RX PubMed=11170746; DOI=10.1006/geno.2000.6431;
RA Lapidot M., Pilpel Y., Gilad Y., Falcovitz A., Sharon D., Haaf T.,
RA Lancet D.;
RT "Mouse-human orthology relationships in an olfactory receptor gene
RT cluster.";
RL Genomics 71:296-306(2001).
RN [7]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 131-242.
RC STRAIN=C57BL/6J;
RX PubMed=8570653; DOI=10.1073/pnas.93.2.884;
RA Sullivan S.L., Adamson M.C., Ressler K.J., Kozak C.A., Buck L.B.;
RT "The chromosomal distribution of mouse odorant receptor genes.";
RL Proc. Natl. Acad. Sci. U.S.A. 93:884-888(1996).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AY073085; AAL60748.1; -; Genomic_DNA.
DR EMBL; AY317501; AAP70924.1; -; Genomic_DNA.
DR EMBL; AL611937; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC104101; AAI04102.1; -; mRNA.
DR EMBL; BC104102; AAI04103.1; -; mRNA.
DR EMBL; AF309126; AAG42796.1; -; Genomic_DNA.
DR EMBL; U28780; AAC52403.1; -; Genomic_DNA.
DR CCDS; CCDS25023.1; -.
DR RefSeq; NP_667214.1; NM_147003.1.
DR AlphaFoldDB; Q60891; -.
DR SMR; Q60891; -.
DR STRING; 10090.ENSMUSP00000049558; -.
DR GlyGen; Q60891; 1 site.
DR iPTMnet; Q60891; -.
DR PhosphoSitePlus; Q60891; -.
DR PaxDb; Q60891; -.
DR PRIDE; Q60891; -.
DR DNASU; 259005; -.
DR Ensembl; ENSMUST00000050678; ENSMUSP00000049558; ENSMUSG00000047444.
DR Ensembl; ENSMUST00000206280; ENSMUSP00000146141; ENSMUSG00000047444.
DR Ensembl; ENSMUST00000214111; ENSMUSP00000148999; ENSMUSG00000047444.
DR GeneID; 259005; -.
DR KEGG; mmu:259005; -.
DR UCSC; uc007kbj.1; mouse.
DR CTD; 259005; -.
DR MGI; MGI:2177522; Olfr139.
DR VEuPathDB; HostDB:ENSMUSG00000047444; -.
DR eggNOG; ENOG502RTW6; Eukaryota.
DR GeneTree; ENSGT00940000163181; -.
DR HOGENOM; CLU_012526_8_1_1; -.
DR InParanoid; Q60891; -.
DR OMA; LLTHQCR; -.
DR OrthoDB; 818570at2759; -.
DR PhylomeDB; Q60891; -.
DR TreeFam; TF352732; -.
DR BioGRID-ORCS; 259005; 2 hits in 65 CRISPR screens.
DR PRO; PR:Q60891; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; Q60891; protein.
DR Bgee; ENSMUSG00000047444; Expressed in secondary oocyte and 3 other tissues.
DR GO; GO:0016021; C:integral component of membrane; ISA:MGI.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; ISA:MGI.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; ISA:MGI.
DR GO; GO:0007608; P:sensory perception of smell; ISA:MGI.
DR GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..315
FT /note="Olfactory receptor 139"
FT /id="PRO_0000150816"
FT TOPO_DOM 1..28
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 29..49
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 50..68
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 69..89
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 90..97
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 98..118
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 119..145
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 146..166
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 167..200
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 201..221
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 222..239
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 240..260
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 261..274
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 275..295
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 296..315
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 8
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 100..192
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT CONFLICT 146
FT /note="T -> Q (in Ref. 6 and 7)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 315 AA; 34425 MW; C82ED163C9DFD792 CRC64;
MEPGAWGNRT AVTDFILLGL TGNVRLQPIL FVVFFFAYIV TVGGNLSILA AIFVEPKLHT
PMYYFLGNLS LLDIGCISVT VPPMLVCLLA HECRVPYAAC ISQLFFFHLL AGVDCHLLTA
MAYDRYLAIC QPLTYSTRMS REVQGTLVGI CCTVSFINAL THTVAVSVLD FCGPNVVNHF
YCDLPPLFQL SCSSIYLNGQ LLFVGATFMG VVPMILISVS YAHVAAAVLR IRSTEGRKKA
FSTCGSHLTV VCIFYGTGFF SYMRLGSVSA SDKDKGIGIL NTILSPMLNP LIYSLRNPDV
QGALKRVLTG KRYPV
