OL140_MOUSE
ID OL140_MOUSE Reviewed; 302 AA.
AC Q60878; Q9R0K1;
DT 22-AUG-2003, integrated into UniProtKB/Swiss-Prot.
DT 10-JAN-2006, sequence version 2.
DT 03-AUG-2022, entry version 148.
DE RecName: Full=Olfactory receptor 140;
DE AltName: Full=Odorant receptor A16;
DE AltName: Full=Olfactory receptor 235-1;
DE AltName: Full=Olfactory receptor 4A;
GN Name=Olfr140; Synonyms=Mor235-1, Olfr4;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=129/SvJ;
RX PubMed=10493742; DOI=10.1523/jneurosci.19-19-08409.1999;
RA Tsuboi A., Yoshihara S., Yamazaki N., Kasai H., Asai-Tsuboi H., Komatsu M.,
RA Serizawa S., Ishii T., Matsuda Y., Nagawa F., Sakano H.;
RT "Olfactory neurons expressing closely linked and homologous odorant
RT receptor genes tend to project their axons to neighboring glomeruli on the
RT olfactory bulb.";
RL J. Neurosci. 19:8409-8418(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=11802173; DOI=10.1038/nn800;
RA Zhang X., Firestein S.;
RT "The olfactory receptor gene superfamily of the mouse.";
RL Nat. Neurosci. 5:124-133(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=11875048; DOI=10.1093/hmg/11.5.535;
RA Young J.M., Friedman C., Williams E.M., Ross J.A., Tonnes-Priddy L.,
RA Trask B.J.;
RT "Different evolutionary processes shaped the mouse and human olfactory
RT receptor gene families.";
RL Hum. Mol. Genet. 11:535-546(2002).
RN [4]
RP ERRATUM OF PUBMED:11875048.
RA Young J.M., Friedman C., Williams E.M., Ross J.A., Tonnes-Priddy L.,
RA Trask B.J.;
RL Hum. Mol. Genet. 11:1683-1683(2002).
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 126-236.
RC STRAIN=C57BL/6J;
RX PubMed=8570653; DOI=10.1073/pnas.93.2.884;
RA Sullivan S.L., Adamson M.C., Ressler K.J., Kozak C.A., Buck L.B.;
RT "The chromosomal distribution of mouse odorant receptor genes.";
RL Proc. Natl. Acad. Sci. U.S.A. 93:884-888(1996).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AB030896; BAA86127.1; -; Genomic_DNA.
DR EMBL; AY073623; AAL61286.1; -; Genomic_DNA.
DR EMBL; AY318468; AAP71660.1; -; Genomic_DNA.
DR EMBL; U28767; AAC52390.1; -; Genomic_DNA.
DR CCDS; CCDS16405.1; -.
DR RefSeq; NP_065261.1; NM_020515.1.
DR AlphaFoldDB; Q60878; -.
DR SMR; Q60878; -.
DR STRING; 10090.ENSMUSP00000107131; -.
DR GlyGen; Q60878; 1 site.
DR PaxDb; Q60878; -.
DR PRIDE; Q60878; -.
DR DNASU; 57272; -.
DR Ensembl; ENSMUST00000099757; ENSMUSP00000097346; ENSMUSG00000075068.
DR Ensembl; ENSMUST00000111506; ENSMUSP00000107131; ENSMUSG00000075068.
DR Ensembl; ENSMUST00000216475; ENSMUSP00000150438; ENSMUSG00000075068.
DR GeneID; 57272; -.
DR KEGG; mmu:57272; -.
DR UCSC; uc008ksl.1; mouse.
DR CTD; 57272; -.
DR MGI; MGI:2177523; Olfr140.
DR VEuPathDB; HostDB:ENSMUSG00000075068; -.
DR eggNOG; ENOG502TK3X; Eukaryota.
DR GeneTree; ENSGT00940000163934; -.
DR HOGENOM; CLU_012526_5_5_1; -.
DR InParanoid; Q60878; -.
DR OMA; CMTPKLV; -.
DR OrthoDB; 947735at2759; -.
DR PhylomeDB; Q60878; -.
DR TreeFam; TF337350; -.
DR BioGRID-ORCS; 57272; 4 hits in 66 CRISPR screens.
DR PRO; PR:Q60878; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; Q60878; protein.
DR Bgee; ENSMUSG00000075068; Expressed in septal olfactory organ and 4 other tissues.
DR Genevisible; Q60878; MM.
DR GO; GO:0016021; C:integral component of membrane; ISA:MGI.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; ISA:MGI.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; ISA:MGI.
DR GO; GO:0007608; P:sensory perception of smell; ISA:MGI.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..302
FT /note="Olfactory receptor 140"
FT /id="PRO_0000150817"
FT TOPO_DOM 1..24
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 25..45
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 46
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 47..67
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 68..95
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 96..116
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 117..139
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 140..160
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 161..191
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 192..212
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 213..236
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 237..257
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 258..266
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 267..287
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 288..302
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 6
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 95..187
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 302 AA; 33734 MW; A8492658DA562060 CRC64;
MDSPRNVTEF FMLGLSQNPQ VQRMLFGLFL LVFLVSVGGN MLIIITITFS PTLGSPMYFF
LSYLSFIDTC YSSCMTPKLI ADSLHEGRAI SFEGCLAQFF VAHLLGGTEI ILLTVMAYDR
YVAICKPLHY TTTMTRHVCI VLVAVAWLGG ILHSTAQLFL VLQLPFCGPN VINHFVCDLY
PLLELACTDT YVIGLLVVAN SGVICLLNFL MLAASYIVIL RTLRSHSAEG RRKALSTCGA
HFTVVALFFV PCIFIYMRPS STLSIDKIVA VFYCILTPMF NPLIYTLRNA EVKNAMKNLW
RK
