OL141_MOUSE
ID OL141_MOUSE Reviewed; 325 AA.
AC Q60880; Q7TR61;
DT 22-AUG-2003, integrated into UniProtKB/Swiss-Prot.
DT 10-JAN-2006, sequence version 2.
DT 25-MAY-2022, entry version 127.
DE RecName: Full=Olfactory receptor 141;
DE AltName: Full=Olfactory receptor 4B;
GN Name=Olfr141; Synonyms=Olfr4;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=14611657; DOI=10.1186/gb-2003-4-11-r71;
RA Young J.M., Shykind B.M., Lane R.P., Tonnes-Priddy L., Ross J.A.,
RA Walker M., Williams E.M., Trask B.J.;
RT "Odorant receptor expressed sequence tags demonstrate olfactory expression
RT of over 400 genes, extensive alternate splicing and unequal expression
RT levels.";
RL Genome Biol. 4:R71.1-R71.13(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 126-237.
RC STRAIN=C57BL/6J;
RX PubMed=8570653; DOI=10.1073/pnas.93.2.884;
RA Sullivan S.L., Adamson M.C., Ressler K.J., Kozak C.A., Buck L.B.;
RT "The chromosomal distribution of mouse odorant receptor genes.";
RL Proc. Natl. Acad. Sci. U.S.A. 93:884-888(1996).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AY318290; AAP71519.1; -; Genomic_DNA.
DR EMBL; U28769; AAC52392.1; -; Genomic_DNA.
DR AlphaFoldDB; Q60880; -.
DR SMR; Q60880; -.
DR STRING; 10090.ENSMUSP00000100847; -.
DR GlyGen; Q60880; 1 site.
DR iPTMnet; Q60880; -.
DR PhosphoSitePlus; Q60880; -.
DR PaxDb; Q60880; -.
DR PRIDE; Q60880; -.
DR UCSC; uc008kmy.1; mouse.
DR MGI; MGI:2177524; Olfr141.
DR eggNOG; ENOG502SHA3; Eukaryota.
DR InParanoid; Q60880; -.
DR PhylomeDB; Q60880; -.
DR PRO; PR:Q60880; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; Q60880; protein.
DR GO; GO:0016021; C:integral component of membrane; ISA:MGI.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0005549; F:odorant binding; IBA:GO_Central.
DR GO; GO:0004984; F:olfactory receptor activity; ISA:MGI.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; ISA:MGI.
DR GO; GO:0007608; P:sensory perception of smell; ISA:MGI.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..325
FT /note="Olfactory receptor 141"
FT /id="PRO_0000150818"
FT TOPO_DOM 1..22
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 23..43
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TRANSMEM 44..64
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 65..97
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 98..118
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 119..139
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 140..160
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 161..194
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 195..215
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 216..234
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 235..255
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 256..269
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 270..290
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 291..325
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 3
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 95..187
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 325 AA; 36673 MW; 6C1A92DB4CF991C5 CRC64;
MRNITEATFF VLKGLTDNNE LQIILFLLFL AIYIFTLIGN VGLIILVVGD SQLHNPMYCF
LSVLSSVDAC YSTDITPNML VGFMSKSKII SFYGCATQMF LAVTFGTTEC FLLAAMAYDR
YVAIHDPLLY AVSMSPRVYI PLIIASYAGG IVHAIIHTVA TFSLSFCRSN EVKHIFCDIP
PLLAISCSET YVNELLLFFF VSFIELVTIL IVLVSYAFIL LSILKMNSSE GRRKVFSTCG
AHLTAVSIYY GTILFMYVRP SSNYSLEHDM IVSTFYTIGI PMLNPIIYSL RNKDVKEAMK
RVLRKKINIK HRIKKLNDFS VFLMP
