OL142_MOUSE
ID OL142_MOUSE Reviewed; 305 AA.
AC Q60881; Q8VGP2;
DT 22-AUG-2003, integrated into UniProtKB/Swiss-Prot.
DT 10-JAN-2006, sequence version 2.
DT 03-AUG-2022, entry version 151.
DE RecName: Full=Olfactory receptor 142;
DE AltName: Full=Olfactory receptor 227-2;
DE AltName: Full=Olfactory receptor 4C;
GN Name=Olfr142; Synonyms=Mor227-2, Olfr4;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=11802173; DOI=10.1038/nn800;
RA Zhang X., Firestein S.;
RT "The olfactory receptor gene superfamily of the mouse.";
RL Nat. Neurosci. 5:124-133(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=11875048; DOI=10.1093/hmg/11.5.535;
RA Young J.M., Friedman C., Williams E.M., Ross J.A., Tonnes-Priddy L.,
RA Trask B.J.;
RT "Different evolutionary processes shaped the mouse and human olfactory
RT receptor gene families.";
RL Hum. Mol. Genet. 11:535-546(2002).
RN [3]
RP ERRATUM OF PUBMED:11875048.
RA Young J.M., Friedman C., Williams E.M., Ross J.A., Tonnes-Priddy L.,
RA Trask B.J.;
RL Hum. Mol. Genet. 11:1683-1683(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 126-236.
RC STRAIN=C57BL/6J;
RX PubMed=8570653; DOI=10.1073/pnas.93.2.884;
RA Sullivan S.L., Adamson M.C., Ressler K.J., Kozak C.A., Buck L.B.;
RT "The chromosomal distribution of mouse odorant receptor genes.";
RL Proc. Natl. Acad. Sci. U.S.A. 93:884-888(1996).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AY073104; AAL60767.1; -; Genomic_DNA.
DR EMBL; AY318475; AAP71664.1; -; Genomic_DNA.
DR EMBL; U28770; AAC52393.1; -; Genomic_DNA.
DR CCDS; CCDS16410.1; -.
DR RefSeq; NP_667195.1; NM_146984.1.
DR AlphaFoldDB; Q60881; -.
DR SMR; Q60881; -.
DR STRING; 10090.ENSMUSP00000097341; -.
DR GlyGen; Q60881; 1 site.
DR iPTMnet; Q60881; -.
DR PhosphoSitePlus; Q60881; -.
DR PaxDb; Q60881; -.
DR PRIDE; Q60881; -.
DR DNASU; 406186; -.
DR Ensembl; ENSMUST00000099752; ENSMUSP00000097341; ENSMUSG00000075063.
DR Ensembl; ENSMUST00000213968; ENSMUSP00000150216; ENSMUSG00000075063.
DR GeneID; 406186; -.
DR KEGG; mmu:406186; -.
DR UCSC; uc008ksp.1; mouse.
DR CTD; 406186; -.
DR MGI; MGI:2177525; Olfr142.
DR VEuPathDB; HostDB:ENSMUSG00000075063; -.
DR eggNOG; ENOG502QVH7; Eukaryota.
DR GeneTree; ENSGT00940000155395; -.
DR HOGENOM; CLU_012526_5_5_1; -.
DR InParanoid; Q60881; -.
DR OMA; YITILVH; -.
DR OrthoDB; 1082090at2759; -.
DR PhylomeDB; Q60881; -.
DR TreeFam; TF337251; -.
DR BioGRID-ORCS; 406186; 0 hits in 65 CRISPR screens.
DR PRO; PR:Q60881; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; Q60881; protein.
DR Bgee; ENSMUSG00000075063; Expressed in respiratory tract epithelium and 4 other tissues.
DR GO; GO:0016021; C:integral component of membrane; ISA:MGI.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; ISA:MGI.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; ISA:MGI.
DR GO; GO:0007608; P:sensory perception of smell; ISA:MGI.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..305
FT /note="Olfactory receptor 142"
FT /id="PRO_0000150819"
FT TOPO_DOM 1..25
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 26..46
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 47..55
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 56..76
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 77..95
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 96..116
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 117..141
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 142..162
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 163..202
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 203..223
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 224..236
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 237..257
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 258..266
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 267..287
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 288..305
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 6
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 95..187
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 305 AA; 34312 MW; 0DFABD868A09678B CRC64;
MANKNNVTEL IFTGLFQDPE VQKVCFVLFL PVYLATLLGN SLILVAVSIS KTLHSPMYFF
LSSLSLVEIC YSSTIVPKFI TDLLAKVKTI SLKGCLTQIF FSHFFGVVEV ILLVVMAYDR
YVAICKPLHY MNIMSRQVCH MLVAGSWLGG FIHSIIQIII TIPLPFCGPN VIDHYFCDLQ
QLFKLACTDT FMEGFIVMAN SGLISIVSLF ILVSSYAVIL ISLRKRSAEG RRKALSTCAS
HITVVILFFV PGAFIYMRPS STFTEDKLVS VFYTVITPML NPIVYTLRNT EMKNAIRMSW
KQKDS
