OL143_MOUSE
ID OL143_MOUSE Reviewed; 313 AA.
AC P34985; Q9EQB3;
DT 01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT 24-JAN-2006, sequence version 2.
DT 25-MAY-2022, entry version 134.
DE RecName: Full=Olfactory receptor 143;
DE AltName: Full=Odorant receptor K18;
DE AltName: Full=Olfactory receptor 170-6;
DE AltName: Full=Olfactory receptor 7A;
GN Name=Olfr143; Synonyms=Mor170-6, Olfr7;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=129/SvJ;
RX PubMed=11130974; DOI=10.1007/s003350010217;
RA Xie S.Y., Feinstein P., Mombaerts P.;
RT "Characterization of a cluster comprising 100 odorant receptor genes in
RT mouse.";
RL Mamm. Genome 11:1070-1078(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=11802173; DOI=10.1038/nn800;
RA Zhang X., Firestein S.;
RT "The olfactory receptor gene superfamily of the mouse.";
RL Nat. Neurosci. 5:124-133(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=11875048; DOI=10.1093/hmg/11.5.535;
RA Young J.M., Friedman C., Williams E.M., Ross J.A., Tonnes-Priddy L.,
RA Trask B.J.;
RT "Different evolutionary processes shaped the mouse and human olfactory
RT receptor gene families.";
RL Hum. Mol. Genet. 11:535-546(2002).
RN [4]
RP ERRATUM OF PUBMED:11875048.
RA Young J.M., Friedman C., Williams E.M., Ross J.A., Tonnes-Priddy L.,
RA Trask B.J.;
RL Hum. Mol. Genet. 11:1683-1683(2002).
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 125-285.
RC STRAIN=C57BL/6J; TISSUE=Liver;
RX PubMed=7683976; DOI=10.1016/0092-8674(93)90145-g;
RA Ressler K.J., Sullivan S.L., Buck L.B.;
RT "A zonal organization of odorant receptor gene expression in the olfactory
RT epithelium.";
RL Cell 73:597-609(1993).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- TISSUE SPECIFICITY: Olfactory epithelium.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AF282276; AAG39861.1; -; Genomic_DNA.
DR EMBL; AY073288; AAL60951.1; -; Genomic_DNA.
DR EMBL; AY318078; AAP71370.1; -; Genomic_DNA.
DR EMBL; L14568; AAA39852.1; -; Genomic_DNA.
DR CCDS; CCDS23002.1; -.
DR PIR; A40745; A40745.
DR AlphaFoldDB; P34985; -.
DR SMR; P34985; -.
DR STRING; 10090.ENSMUSP00000091388; -.
DR GlyGen; P34985; 1 site.
DR iPTMnet; P34985; -.
DR PhosphoSitePlus; P34985; -.
DR PaxDb; P34985; -.
DR PRIDE; P34985; -.
DR MGI; MGI:2177526; Olfr143.
DR eggNOG; ENOG502TKYT; Eukaryota.
DR InParanoid; P34985; -.
DR PhylomeDB; P34985; -.
DR PRO; PR:P34985; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; P34985; protein.
DR GO; GO:0016021; C:integral component of membrane; ISA:MGI.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0005549; F:odorant binding; IBA:GO_Central.
DR GO; GO:0004984; F:olfactory receptor activity; ISA:MGI.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; ISA:MGI.
DR GO; GO:0007608; P:sensory perception of smell; ISA:MGI.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..313
FT /note="Olfactory receptor 143"
FT /id="PRO_0000150820"
FT TOPO_DOM 1..27
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 28..48
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 49..59
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 60..80
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 81..96
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 97..117
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 118..136
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 137..157
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 158..208
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 209..229
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 230..239
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 240..260
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 261..274
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 275..295
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 296..313
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 8
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 100..192
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 313 AA; 35201 MW; C6EEC999DB3FC000 CRC64;
MMQITMENKS SVSEFILMGL TDQPELQLPL FVLFLMNYTA TVMGNLTLMN LICLNSNLHT
PMYFFLFNLS FIDFCYSMVF TPKMLMSFIL EKNTISFGGC MAQLFFFLFF VNSESYVLTA
MAYDRYVAIC KPLTYKVIMS PKICCLLIFS SYLMGFASAM AHTGCMIRLS FCDSNIINHY
MCDIFPLLPL SCSSTYVNEL MSSVVVGSAI ILCCLIILIS YAMILFNIIH MSSGKGWSKA
LGTCGSHIIT VSLFYGSGLL AYVKPSSAKT VGQGKFFSVF YTLLVPMLNP LIYSLRNKDV
KLAVKKTWKR ITS
