OL146_MOUSE
ID OL146_MOUSE Reviewed; 306 AA.
AC Q60884; A3KMK0; Q9EQ89;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 10-JAN-2006, sequence version 2.
DT 03-AUG-2022, entry version 145.
DE RecName: Full=Olfactory receptor 146;
DE AltName: Full=Odorant receptor M15;
DE AltName: Full=Olfactory receptor 171-10;
DE AltName: Full=Olfactory receptor 7D;
GN Name=Olfr146; Synonyms=Mor171-10, Olfr7;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=129/SvJ;
RX PubMed=11130974; DOI=10.1007/s003350010217;
RA Xie S.Y., Feinstein P., Mombaerts P.;
RT "Characterization of a cluster comprising 100 odorant receptor genes in
RT mouse.";
RL Mamm. Genome 11:1070-1078(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=11802173; DOI=10.1038/nn800;
RA Zhang X., Firestein S.;
RT "The olfactory receptor gene superfamily of the mouse.";
RL Nat. Neurosci. 5:124-133(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=11875048; DOI=10.1093/hmg/11.5.535;
RA Young J.M., Friedman C., Williams E.M., Ross J.A., Tonnes-Priddy L.,
RA Trask B.J.;
RT "Different evolutionary processes shaped the mouse and human olfactory
RT receptor gene families.";
RL Hum. Mol. Genet. 11:535-546(2002).
RN [4]
RP ERRATUM OF PUBMED:11875048.
RA Young J.M., Friedman C., Williams E.M., Ross J.A., Tonnes-Priddy L.,
RA Trask B.J.;
RL Hum. Mol. Genet. 11:1683-1683(2002).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 128-239.
RC STRAIN=C57BL/6J;
RX PubMed=8570653; DOI=10.1073/pnas.93.2.884;
RA Sullivan S.L., Adamson M.C., Ressler K.J., Kozak C.A., Buck L.B.;
RT "The chromosomal distribution of mouse odorant receptor genes.";
RL Proc. Natl. Acad. Sci. U.S.A. 93:884-888(1996).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AF282300; AAG39885.1; -; Genomic_DNA.
DR EMBL; AY073348; AAL61011.1; -; Genomic_DNA.
DR EMBL; AY318123; AAP71405.1; -; Genomic_DNA.
DR EMBL; BC132188; AAI32189.1; -; mRNA.
DR EMBL; BC132190; AAI32191.1; -; mRNA.
DR EMBL; U28773; AAC52396.1; -; Genomic_DNA.
DR CCDS; CCDS23036.1; -.
DR RefSeq; NP_666958.1; NM_146747.1.
DR AlphaFoldDB; Q60884; -.
DR SMR; Q60884; -.
DR STRING; 10090.ENSMUSP00000073352; -.
DR GlyGen; Q60884; 1 site.
DR iPTMnet; Q60884; -.
DR PhosphoSitePlus; Q60884; -.
DR PaxDb; Q60884; -.
DR PRIDE; Q60884; -.
DR Ensembl; ENSMUST00000073671; ENSMUSP00000073352; ENSMUSG00000058820.
DR Ensembl; ENSMUST00000214410; ENSMUSP00000149294; ENSMUSG00000058820.
DR GeneID; 258742; -.
DR KEGG; mmu:258742; -.
DR UCSC; uc009oxn.1; mouse.
DR CTD; 258742; -.
DR MGI; MGI:2660711; Olfr146.
DR VEuPathDB; HostDB:ENSMUSG00000058820; -.
DR eggNOG; ENOG502SJS1; Eukaryota.
DR GeneTree; ENSGT01040000240383; -.
DR HOGENOM; CLU_012526_1_0_1; -.
DR InParanoid; Q60884; -.
DR OMA; FYSECIT; -.
DR OrthoDB; 1075792at2759; -.
DR PhylomeDB; Q60884; -.
DR TreeFam; TF352753; -.
DR BioGRID-ORCS; 258742; 4 hits in 63 CRISPR screens.
DR PRO; PR:Q60884; -.
DR Proteomes; UP000000589; Chromosome 9.
DR RNAct; Q60884; protein.
DR Bgee; ENSMUSG00000058820; Expressed in adrenal gland and 1 other tissue.
DR ExpressionAtlas; Q60884; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; ISA:MGI.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0005549; F:odorant binding; IBA:GO_Central.
DR GO; GO:0004984; F:olfactory receptor activity; ISA:MGI.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; ISA:MGI.
DR GO; GO:0007608; P:sensory perception of smell; ISA:MGI.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; G-protein coupled receptor; Glycoprotein; Membrane;
KW Olfaction; Receptor; Reference proteome; Sensory transduction; Transducer;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..306
FT /note="Olfactory receptor 146"
FT /id="PRO_0000150823"
FT TOPO_DOM 1..28
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 29..49
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 50..56
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 57..77
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 78..97
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 98..118
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 119..143
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 144..164
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 165..196
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 197..217
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 218..236
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 237..257
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 258..271
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 272..292
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 293..306
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 306 AA; 34373 MW; 05776FB23AD5A6D2 CRC64;
MEKGNQSTVN KFFLSGLTEQ PELQLPLFLL FLGIYLLTVL GNLGMIILIL LSSYLHTPMY
FFLSSLSFID FCQSTVITPK MLVKFVREKN EISYPECITQ LCFFVIFAVS ESYMLAAMAY
DRYVAICSPL LYSSIMSQHK CLSLVLGVYI LGIVCASAHV GCIFRIDFCK SDLINHYFCD
LISILNLSCS NIFVNDLVIL IFSLINTIFP TLTILSSYAF IIISILRIKS TEGRSKAFST
CSSHISAVAI FYISAGFTYL NPSSSHSMDE GKVSSIFYTI IVPMLNPLIY SLRNKDVKIA
LKKMIE
