OL147_MOUSE
ID OL147_MOUSE Reviewed; 317 AA.
AC Q60886; Q7TRD2; Q8VGC9;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 24-JAN-2006, sequence version 2.
DT 03-AUG-2022, entry version 149.
DE RecName: Full=Olfactory receptor 147;
DE AltName: Full=Odorant receptor M3;
DE AltName: Full=Olfactory receptor 164-1;
DE AltName: Full=Olfactory receptor 7E;
GN Name=Olfr147; Synonyms=Mor164-1, Olfr7;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=11802173; DOI=10.1038/nn800;
RA Zhang X., Firestein S.;
RT "The olfactory receptor gene superfamily of the mouse.";
RL Nat. Neurosci. 5:124-133(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=11875048; DOI=10.1093/hmg/11.5.535;
RA Young J.M., Friedman C., Williams E.M., Ross J.A., Tonnes-Priddy L.,
RA Trask B.J.;
RT "Different evolutionary processes shaped the mouse and human olfactory
RT receptor gene families.";
RL Hum. Mol. Genet. 11:535-546(2002).
RN [3]
RP ERRATUM OF PUBMED:11875048.
RA Young J.M., Friedman C., Williams E.M., Ross J.A., Tonnes-Priddy L.,
RA Trask B.J.;
RL Hum. Mol. Genet. 11:1683-1683(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 131-242.
RC STRAIN=C57BL/6J;
RX PubMed=8570653; DOI=10.1073/pnas.93.2.884;
RA Sullivan S.L., Adamson M.C., Ressler K.J., Kozak C.A., Buck L.B.;
RT "The chromosomal distribution of mouse odorant receptor genes.";
RL Proc. Natl. Acad. Sci. U.S.A. 93:884-888(1996).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AY073221; AAL60884.1; -; Genomic_DNA.
DR EMBL; AY318086; AAP71376.2; -; Genomic_DNA.
DR EMBL; U28775; AAC52398.1; -; Genomic_DNA.
DR CCDS; CCDS23008.1; -.
DR RefSeq; NP_667080.1; NM_146869.2.
DR AlphaFoldDB; Q60886; -.
DR SMR; Q60886; -.
DR STRING; 10090.ENSMUSP00000051933; -.
DR GlyGen; Q60886; 1 site.
DR iPTMnet; Q60886; -.
DR PhosphoSitePlus; Q60886; -.
DR PaxDb; Q60886; -.
DR PRIDE; Q60886; -.
DR DNASU; 258869; -.
DR Ensembl; ENSMUST00000056364; ENSMUSP00000051933; ENSMUSG00000049098.
DR GeneID; 258869; -.
DR KEGG; mmu:258869; -.
DR UCSC; uc009owi.2; mouse.
DR CTD; 258869; -.
DR MGI; MGI:2660712; Olfr147.
DR VEuPathDB; HostDB:ENSMUSG00000049098; -.
DR eggNOG; ENOG502RTZT; Eukaryota.
DR GeneTree; ENSGT01010000222320; -.
DR HOGENOM; CLU_012526_1_0_1; -.
DR InParanoid; Q60886; -.
DR OMA; FQQPFFF; -.
DR OrthoDB; 954097at2759; -.
DR PhylomeDB; Q60886; -.
DR TreeFam; TF352753; -.
DR Reactome; R-MMU-381753; Olfactory Signaling Pathway.
DR BioGRID-ORCS; 258869; 2 hits in 65 CRISPR screens.
DR PRO; PR:Q60886; -.
DR Proteomes; UP000000589; Chromosome 9.
DR RNAct; Q60886; protein.
DR ExpressionAtlas; Q60886; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; ISA:MGI.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0005549; F:odorant binding; IBA:GO_Central.
DR GO; GO:0004984; F:olfactory receptor activity; ISA:MGI.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; ISA:MGI.
DR GO; GO:0007608; P:sensory perception of smell; ISA:MGI.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; G-protein coupled receptor; Glycoprotein; Membrane;
KW Olfaction; Receptor; Reference proteome; Sensory transduction; Transducer;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..317
FT /note="Olfactory receptor 147"
FT /id="PRO_0000150824"
FT TOPO_DOM 1..32
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 33..53
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 54..59
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 60..80
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 81..97
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 98..118
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 119..136
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 137..157
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 158..199
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 200..220
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 221..242
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 243..263
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 264..274
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 275..294
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 295..317
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 8
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 317 AA; 35358 MW; 072F2969380B5F82 CRC64;
MISMLAGNGS SVTEFVLAGL TDRPELQLPL FYLFLIIYII TVVGNLGLII LIGLNPHLHT
PMYYFLFNLS FIDLCYSSVF SPKMLINFVS EKNSISYAGC MTQLFLFLFF VISECYMLTS
MAYDRYVAIC NPLLYKVTMS PQICSVISFA AYGMGFAGSS AHTGCMLRLT FCNVNVINHY
LCDILPLLQL SCTSTYVNEV VVLIVVGINI TVPSFTILIS YVFILANILN IKSTQGRAKA
FSTCSSHIMA ISLFFGSAAF MYLKYSSGSM EQGKISSVFY TNVGPMLNPL IYSLRNKDVK
VALRKSLIKF REKTDFN
