OL148_MOUSE
ID OL148_MOUSE Reviewed; 310 AA.
AC Q60887; Q9EQ88;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 24-JAN-2006, sequence version 2.
DT 03-AUG-2022, entry version 145.
DE RecName: Full=Olfactory receptor 148;
DE AltName: Full=Odorant receptor M30;
DE AltName: Full=Olfactory receptor 224-4;
DE AltName: Full=Olfactory receptor 7F;
GN Name=Olfr148; Synonyms=Mor224-4, Olfr7;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=129/SvJ;
RX PubMed=11130974; DOI=10.1007/s003350010217;
RA Xie S.Y., Feinstein P., Mombaerts P.;
RT "Characterization of a cluster comprising 100 odorant receptor genes in
RT mouse.";
RL Mamm. Genome 11:1070-1078(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=11802173; DOI=10.1038/nn800;
RA Zhang X., Firestein S.;
RT "The olfactory receptor gene superfamily of the mouse.";
RL Nat. Neurosci. 5:124-133(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=11875048; DOI=10.1093/hmg/11.5.535;
RA Young J.M., Friedman C., Williams E.M., Ross J.A., Tonnes-Priddy L.,
RA Trask B.J.;
RT "Different evolutionary processes shaped the mouse and human olfactory
RT receptor gene families.";
RL Hum. Mol. Genet. 11:535-546(2002).
RN [4]
RP ERRATUM OF PUBMED:11875048.
RA Young J.M., Friedman C., Williams E.M., Ross J.A., Tonnes-Priddy L.,
RA Trask B.J.;
RL Hum. Mol. Genet. 11:1683-1683(2002).
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 126-237.
RC STRAIN=C57BL/6J;
RX PubMed=8570653; DOI=10.1073/pnas.93.2.884;
RA Sullivan S.L., Adamson M.C., Ressler K.J., Kozak C.A., Buck L.B.;
RT "The chromosomal distribution of mouse odorant receptor genes.";
RL Proc. Natl. Acad. Sci. U.S.A. 93:884-888(1996).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AF282301; AAG39886.1; -; Genomic_DNA.
DR EMBL; AY073592; AAL61255.1; -; Genomic_DNA.
DR EMBL; AY318151; AAP71423.1; -; Genomic_DNA.
DR EMBL; U28776; AAC52399.1; -; Genomic_DNA.
DR CCDS; CCDS23053.1; -.
DR RefSeq; NP_666716.1; NM_146505.1.
DR AlphaFoldDB; Q60887; -.
DR SMR; Q60887; -.
DR STRING; 10090.ENSMUSP00000096473; -.
DR GlyGen; Q60887; 1 site.
DR iPTMnet; Q60887; -.
DR PhosphoSitePlus; Q60887; -.
DR PaxDb; Q60887; -.
DR PRIDE; Q60887; -.
DR Ensembl; ENSMUST00000050807; ENSMUSP00000096473; ENSMUSG00000048299.
DR Ensembl; ENSMUST00000216801; ENSMUSP00000150761; ENSMUSG00000048299.
DR GeneID; 258498; -.
DR KEGG; mmu:258498; -.
DR UCSC; uc009oyg.1; mouse.
DR CTD; 258498; -.
DR MGI; MGI:2660713; Olfr148.
DR VEuPathDB; HostDB:ENSMUSG00000048299; -.
DR eggNOG; ENOG502SH9P; Eukaryota.
DR GeneTree; ENSGT01050000244869; -.
DR HOGENOM; CLU_012526_8_1_1; -.
DR InParanoid; Q60887; -.
DR OMA; CTEGVLY; -.
DR OrthoDB; 965105at2759; -.
DR PhylomeDB; Q60887; -.
DR TreeFam; TF336512; -.
DR BioGRID-ORCS; 258498; 2 hits in 65 CRISPR screens.
DR PRO; PR:Q60887; -.
DR Proteomes; UP000000589; Chromosome 9.
DR RNAct; Q60887; protein.
DR Bgee; ENSMUSG00000048299; Expressed in vomeronasal organ and 5 other tissues.
DR ExpressionAtlas; Q60887; differential.
DR GO; GO:0016021; C:integral component of membrane; ISA:MGI.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; ISA:MGI.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; ISA:MGI.
DR GO; GO:0007608; P:sensory perception of smell; ISA:MGI.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..310
FT /note="Olfactory receptor 148"
FT /id="PRO_0000150825"
FT TOPO_DOM 1..23
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 24..44
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 45..55
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 56..76
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 77..95
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 96..116
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 117..136
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 137..157
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 158..202
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 203..223
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 224..237
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 238..258
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 259..264
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 265..285
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 286..310
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 3
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 95..187
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 310 AA; 34662 MW; EBABBD625F57C96F CRC64;
MDNYTLLNEF ILLGIPQTQG LETLLFVVFL FIYFFTLLGN SLIFTAIISS STLHTPMYFF
LGLLSVFDML FPSVTCPKML FYLSVRSPAI SYKGCAAQLF FYHLLGSTEG CLYSVMAYDR
YVAICHPLRY MLIMKPGVCV SLVIIAWLVG CLHATILTSL TFQLVYCASN QVDYFFCDLP
AVLPLACTDS KLARKVGSIN VGFLALMLLF SVCVSYVHIG VAILRIRSAE GRQKAFSTCS
AHLTAILCAY GPVIIIYLQR TPNPLLGAVV QILNNIVSPM LNSLIYSLRN KEVKRSLRRV
FQNITFHGQK
