OL149_MOUSE
ID OL149_MOUSE Reviewed; 311 AA.
AC Q60888; B9EJ08; Q7TRA8; Q8VEP7;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 24-JAN-2006, sequence version 2.
DT 03-AUG-2022, entry version 133.
DE RecName: Full=Olfactory receptor 149;
DE AltName: Full=Odorant receptor M31;
DE AltName: Full=Olfactory receptor 224-8;
DE AltName: Full=Olfactory receptor 7G;
GN Name=Olfr149; Synonyms=Mor224-8, Olfr7;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=14611657; DOI=10.1186/gb-2003-4-11-r71;
RA Young J.M., Shykind B.M., Lane R.P., Tonnes-Priddy L., Ross J.A.,
RA Walker M., Williams E.M., Trask B.J.;
RT "Odorant receptor expressed sequence tags demonstrate olfactory expression
RT of over 400 genes, extensive alternate splicing and unequal expression
RT levels.";
RL Genome Biol. 4:R71.1-R71.13(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 91-311.
RX PubMed=11802173; DOI=10.1038/nn800;
RA Zhang X., Firestein S.;
RT "The olfactory receptor gene superfamily of the mouse.";
RL Nat. Neurosci. 5:124-133(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 91-311.
RX PubMed=11875048; DOI=10.1093/hmg/11.5.535;
RA Young J.M., Friedman C., Williams E.M., Ross J.A., Tonnes-Priddy L.,
RA Trask B.J.;
RT "Different evolutionary processes shaped the mouse and human olfactory
RT receptor gene families.";
RL Hum. Mol. Genet. 11:535-546(2002).
RN [5]
RP ERRATUM OF PUBMED:11875048.
RA Young J.M., Friedman C., Williams E.M., Ross J.A., Tonnes-Priddy L.,
RA Trask B.J.;
RL Hum. Mol. Genet. 11:1683-1683(2002).
RN [6]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 126-237.
RC STRAIN=C57BL/6J;
RX PubMed=8570653; DOI=10.1073/pnas.93.2.884;
RA Sullivan S.L., Adamson M.C., Ressler K.J., Kozak C.A., Buck L.B.;
RT "The chromosomal distribution of mouse odorant receptor genes.";
RL Proc. Natl. Acad. Sci. U.S.A. 93:884-888(1996).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; BC141260; AAI41261.1; -; mRNA.
DR EMBL; AY318157; AAP71427.1; -; Genomic_DNA.
DR EMBL; AY073853; AAL61516.1; -; Genomic_DNA.
DR EMBL; U28777; AAC52400.1; -; Genomic_DNA.
DR CCDS; CCDS23057.1; -.
DR RefSeq; NP_997021.1; NM_207138.1.
DR AlphaFoldDB; Q60888; -.
DR SMR; Q60888; -.
DR STRING; 10090.ENSMUSP00000080686; -.
DR PaxDb; Q60888; -.
DR PRIDE; Q60888; -.
DR Ensembl; ENSMUST00000082027; ENSMUSP00000080686; ENSMUSG00000062121.
DR Ensembl; ENSMUST00000215192; ENSMUSP00000149664; ENSMUSG00000062121.
DR GeneID; 235256; -.
DR KEGG; mmu:235256; -.
DR UCSC; uc009oyk.1; mouse.
DR CTD; 235256; -.
DR MGI; MGI:2660716; Olfr149.
DR VEuPathDB; HostDB:ENSMUSG00000062121; -.
DR eggNOG; ENOG502SH9P; Eukaryota.
DR GeneTree; ENSGT01050000244869; -.
DR HOGENOM; CLU_012526_8_1_1; -.
DR InParanoid; Q60888; -.
DR OMA; RPLCFLS; -.
DR OrthoDB; 885965at2759; -.
DR PhylomeDB; Q60888; -.
DR TreeFam; TF336512; -.
DR BioGRID-ORCS; 235256; 2 hits in 64 CRISPR screens.
DR PRO; PR:Q60888; -.
DR Proteomes; UP000000589; Chromosome 9.
DR RNAct; Q60888; protein.
DR Bgee; ENSMUSG00000062121; Expressed in reproductive organ and 1 other tissue.
DR GO; GO:0016021; C:integral component of membrane; ISA:MGI.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; ISA:MGI.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; ISA:MGI.
DR GO; GO:0007608; P:sensory perception of smell; ISA:MGI.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Membrane;
KW Olfaction; Receptor; Reference proteome; Sensory transduction; Transducer;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..311
FT /note="Olfactory receptor 149"
FT /id="PRO_0000150826"
FT TOPO_DOM 1..24
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 25..45
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 46..54
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 55..75
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 76..95
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 96..116
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 117..137
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 138..158
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 159..192
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 193..213
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 214..237
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 238..258
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 259..271
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 272..288
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 289..311
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DISULFID 95..187
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT CONFLICT 100
FT /note="F -> V (in Ref. 3 and 4)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 311 AA; 35274 MW; 20CA601A59FB00E8 CRC64;
MKNLSVVTQF ILLGIPHTEG VETMLFVLFF SFYIFTLVGN LLILLAIVSS SRLHTPMYFF
LCQLSVCDIF FPSVSSPKML FYLSGNTPAI SYAGCVSQLF FYHFLGGTEC FLYTVMAYDR
FVAICYPLRY SVIMSHRICA FLAMGTAVFG CIHSTFLTTL TFQLPYCGPK DVNYYFCDIP
VVMKLACADT STLEMVGFIS VGLMPLSCFF FILTSYSCIV RSILQIRSTE GRHRAFSTCS
AHFTAILLFY MPVIFIYLRP TPSPWLDATV QILNNLVTPM LNPLIYSLRN KEVKSSLWTV
LHLLCFLPKH L
