OL150_MOUSE
ID OL150_MOUSE Reviewed; 312 AA.
AC Q60895; E9QLS5; Q8VFN2;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 27-JUL-2011, sequence version 3.
DT 03-AUG-2022, entry version 150.
DE RecName: Full=Olfactory receptor 150;
DE AltName: Full=Odorant receptor M93;
DE AltName: Full=Olfactory receptor 171-18;
DE AltName: Full=Olfactory receptor 7I;
GN Name=Olfr150; Synonyms=Mor171-18, Olfr7;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=11802173; DOI=10.1038/nn800;
RA Zhang X., Firestein S.;
RT "The olfactory receptor gene superfamily of the mouse.";
RL Nat. Neurosci. 5:124-133(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=11875048; DOI=10.1093/hmg/11.5.535;
RA Young J.M., Friedman C., Williams E.M., Ross J.A., Tonnes-Priddy L.,
RA Trask B.J.;
RT "Different evolutionary processes shaped the mouse and human olfactory
RT receptor gene families.";
RL Hum. Mol. Genet. 11:535-546(2002).
RN [3]
RP ERRATUM OF PUBMED:11875048.
RA Young J.M., Friedman C., Williams E.M., Ross J.A., Tonnes-Priddy L.,
RA Trask B.J.;
RL Hum. Mol. Genet. 11:1683-1683(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 128-239.
RC STRAIN=C57BL/6J;
RX PubMed=8570653; DOI=10.1073/pnas.93.2.884;
RA Sullivan S.L., Adamson M.C., Ressler K.J., Kozak C.A., Buck L.B.;
RT "The chromosomal distribution of mouse odorant receptor genes.";
RL Proc. Natl. Acad. Sci. U.S.A. 93:884-888(1996).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AY073488; AAL61151.1; -; Genomic_DNA.
DR EMBL; AY318160; AAP71429.1; -; Genomic_DNA.
DR EMBL; CT025612; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; U28784; AAC52407.1; -; Genomic_DNA.
DR CCDS; CCDS52773.1; -.
DR RefSeq; NP_666820.2; NM_146609.2.
DR AlphaFoldDB; Q60895; -.
DR SMR; Q60895; -.
DR STRING; 10090.ENSMUSP00000077635; -.
DR GlyGen; Q60895; 1 site.
DR iPTMnet; Q60895; -.
DR PhosphoSitePlus; Q60895; -.
DR PaxDb; Q60895; -.
DR PRIDE; Q60895; -.
DR Ensembl; ENSMUST00000078557; ENSMUSP00000077635; ENSMUSG00000094353.
DR Ensembl; ENSMUST00000217257; ENSMUSP00000150024; ENSMUSG00000094353.
DR GeneID; 258602; -.
DR KEGG; mmu:258602; -.
DR UCSC; uc012grg.1; mouse.
DR CTD; 258602; -.
DR MGI; MGI:2659178; Olfr150.
DR VEuPathDB; HostDB:ENSMUSG00000094353; -.
DR eggNOG; ENOG502SJS1; Eukaryota.
DR GeneTree; ENSGT01040000240383; -.
DR HOGENOM; CLU_012526_1_0_1; -.
DR InParanoid; Q60895; -.
DR OMA; LIERWIG; -.
DR OrthoDB; 469172at2759; -.
DR PhylomeDB; Q60895; -.
DR TreeFam; TF352753; -.
DR BioGRID-ORCS; 258602; 4 hits in 46 CRISPR screens.
DR PRO; PR:Q60895; -.
DR Proteomes; UP000000589; Chromosome 9.
DR RNAct; Q60895; protein.
DR Bgee; ENSMUSG00000094353; Expressed in olfactory bulb.
DR GO; GO:0016021; C:integral component of membrane; ISA:MGI.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR GO; GO:0004984; F:olfactory receptor activity; ISA:MGI.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; ISA:MGI.
DR GO; GO:0007608; P:sensory perception of smell; ISA:MGI.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..312
FT /note="Olfactory receptor 150"
FT /id="PRO_0000150827"
FT TOPO_DOM 1..28
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 29..49
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 50..56
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 57..77
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 78..99
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 100..120
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 121..143
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 144..164
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 165..204
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 205..225
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 226..244
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 245..265
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 266..274
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 275..292
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 293..312
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 97..189
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT CONFLICT 15
FT /note="S -> A (in Ref. 1; AAL61151 and 2; AAP71429)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 312 AA; 35457 MW; 063BD7134CF48E8C CRC64;
MAYSNQSRVT EFIISGLTNK PELQLPLFLL FLGIYLFTVL GNLGMIILIL LSSHLHTPMY
FFLSSLSFID LCYSTIITPK MLVNFVTTKN VISYQECMTQ LYFFIAFVIS ECHMLAAMAY
DRYVAICNPL LYNVTMSYQV CSWMVGGVYG MGFIGAAIHT FCMLRVVFCK DNIINHYFCD
LFPLMELACS STYVNEVVLL SLSAFNIFIP TLTILGSYIF IIISILRIKS TEGRFKAFST
CSSHFSAVSV FFGSLAFMYL QPFSVSSKDK GKVSSVFYTT IVPMLNPMIY SLRNRDVKLA
LNKLFQKKKF HV
