OL151_MOUSE
ID OL151_MOUSE Reviewed; 309 AA.
AC Q60893; B2RQX1; Q7TRE7; Q9ERU6;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 24-JAN-2006, sequence version 2.
DT 03-AUG-2022, entry version 137.
DE RecName: Full=Olfactory receptor 151;
DE AltName: Full=Odorant receptor M71;
DE AltName: Full=Olfactory receptor 171-2;
DE AltName: Full=Olfactory receptor 7H;
GN Name=Olfr151; Synonyms=Mor171-2, Olfr7;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=129/SvJ;
RA Feinstein P., Mombaerts P.;
RT "An Olfr7 odorant receptor, M71.";
RL Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=11802173; DOI=10.1038/nn800;
RA Zhang X., Firestein S.;
RT "The olfactory receptor gene superfamily of the mouse.";
RL Nat. Neurosci. 5:124-133(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=11875048; DOI=10.1093/hmg/11.5.535;
RA Young J.M., Friedman C., Williams E.M., Ross J.A., Tonnes-Priddy L.,
RA Trask B.J.;
RT "Different evolutionary processes shaped the mouse and human olfactory
RT receptor gene families.";
RL Hum. Mol. Genet. 11:535-546(2002).
RN [4]
RP ERRATUM OF PUBMED:11875048.
RA Young J.M., Friedman C., Williams E.M., Ross J.A., Tonnes-Priddy L.,
RA Trask B.J.;
RL Hum. Mol. Genet. 11:1683-1683(2002).
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=14611657; DOI=10.1186/gb-2003-4-11-r71;
RA Young J.M., Shykind B.M., Lane R.P., Tonnes-Priddy L., Ross J.A.,
RA Walker M., Williams E.M., Trask B.J.;
RT "Odorant receptor expressed sequence tags demonstrate olfactory expression
RT of over 400 genes, extensive alternate splicing and unequal expression
RT levels.";
RL Genome Biol. 4:R71.1-R71.13(2003).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [7]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 128-238.
RC STRAIN=C57BL/6J;
RX PubMed=8570653; DOI=10.1073/pnas.93.2.884;
RA Sullivan S.L., Adamson M.C., Ressler K.J., Kozak C.A., Buck L.B.;
RT "The chromosomal distribution of mouse odorant receptor genes.";
RL Proc. Natl. Acad. Sci. U.S.A. 93:884-888(1996).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AF281061; AAG29379.1; -; Genomic_DNA.
DR EMBL; AY073205; AAL60868.1; -; Genomic_DNA.
DR EMBL; AY318055; AAP71352.1; -; Genomic_DNA.
DR EMBL; BC138117; AAI38118.1; -; mRNA.
DR EMBL; BC138118; AAI38119.1; -; mRNA.
DR EMBL; U28782; AAC52405.1; -; Genomic_DNA.
DR RefSeq; NP_997547.1; NM_207664.2.
DR AlphaFoldDB; Q60893; -.
DR SMR; Q60893; -.
DR STRING; 10090.ENSMUSP00000100468; -.
DR PaxDb; Q60893; -.
DR PRIDE; Q60893; -.
DR DNASU; 406176; -.
DR GeneID; 406176; -.
DR KEGG; mmu:406176; -.
DR UCSC; uc009ovk.2; mouse.
DR CTD; 406176; -.
DR MGI; MGI:2661338; Olfr151.
DR eggNOG; ENOG502T9KS; Eukaryota.
DR InParanoid; Q60893; -.
DR OrthoDB; 936657at2759; -.
DR PhylomeDB; Q60893; -.
DR BioGRID-ORCS; 406176; 2 hits in 13 CRISPR screens.
DR PRO; PR:Q60893; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; Q60893; protein.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; TAS:Reactome.
DR GO; GO:0016021; C:integral component of membrane; ISA:MGI.
DR GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0005549; F:odorant binding; IBA:GO_Central.
DR GO; GO:0004984; F:olfactory receptor activity; ISA:MGI.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; ISA:MGI.
DR GO; GO:0007608; P:sensory perception of smell; ISA:MGI.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Membrane;
KW Olfaction; Receptor; Reference proteome; Sensory transduction; Transducer;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..309
FT /note="Olfactory receptor 151"
FT /id="PRO_0000150828"
FT TOPO_DOM 1..28
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 29..49
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 50..56
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 57..77
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 78..90
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 91..111
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 112..133
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 134..154
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 155..195
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 196..216
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 217..238
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 239..259
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 260..270
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 271..291
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 292..309
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DISULFID 97..188
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT CONFLICT 231
FT /note="E -> G (in Ref. 7; AAC52405)"
FT /evidence="ECO:0000305"
FT CONFLICT 284
FT /note="F -> L (in Ref. 5; AAP71352)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 309 AA; 34465 MW; F12EFD8F5937B86F CRC64;
MTAENQSTVT EFILGGLTNR PELQLPLFLL FLGIYVVTMV GNLGMITLIG LNSQLHTPMY
FFLSNLSLVD LCYSSVITPK MLINFVSQRN LISYVGCMSQ LYFFLVFVIA ECYMLTVMAY
DRYVAICQPL LYNIIMSPAL CSLLVAFVYA VGLIGSAIET GLMLKLNYCE DLISHYFCDI
LPLMKLSCSS TYDVEMAVFF LAGFDIIVTS LTVLISYAFI LSSILRISSN EGRSKAFSTC
SSHFAAVGLF YGSTAFMYLK PSTASSLAQE NVASVFYTTV IPMFNPLIYS LRNKEVKTAL
DKTLRRKVF
