OL154_MOUSE
ID OL154_MOUSE Reviewed; 318 AA.
AC Q9QY00; A2ALD1; Q0VBG5;
DT 26-SEP-2003, integrated into UniProtKB/Swiss-Prot.
DT 27-JUL-2011, sequence version 2.
DT 03-AUG-2022, entry version 153.
DE RecName: Full=Olfactory receptor 154;
DE AltName: Full=Olfactory receptor 175-1;
GN Name=Olfr154; Synonyms=Mor175-1, Olfr4-3, Or912-93, Or93;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=10594242; DOI=10.1007/s003359901185;
RA Rouquier S., Stubbs L., Gaillard-Sanchez I., Giorgi D.G.;
RT "Sequence and chromosomal localization of the mouse ortholog of the human
RT olfactory receptor gene 912-93.";
RL Mamm. Genome 10:1172-1174(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=11802173; DOI=10.1038/nn800;
RA Zhang X., Firestein S.;
RT "The olfactory receptor gene superfamily of the mouse.";
RL Nat. Neurosci. 5:124-133(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=11875048; DOI=10.1093/hmg/11.5.535;
RA Young J.M., Friedman C., Williams E.M., Ross J.A., Tonnes-Priddy L.,
RA Trask B.J.;
RT "Different evolutionary processes shaped the mouse and human olfactory
RT receptor gene families.";
RL Hum. Mol. Genet. 11:535-546(2002).
RN [4]
RP ERRATUM OF PUBMED:11875048.
RA Young J.M., Friedman C., Williams E.M., Ross J.A., Tonnes-Priddy L.,
RA Trask B.J.;
RL Hum. Mol. Genet. 11:1683-1683(2002).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [7]
RP PROTEIN SEQUENCE OF 228-236, AND IDENTIFICATION BY MASS SPECTROMETRY.
RC STRAIN=C57BL/6J; TISSUE=Brain;
RA Lubec G., Kang S.U.;
RL Submitted (APR-2007) to UniProtKB.
CC -!- FUNCTION: Potential odorant receptor.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AF146372; AAF20365.1; -; Genomic_DNA.
DR EMBL; AY073523; AAL61186.1; -; Genomic_DNA.
DR EMBL; AY318199; AAP71458.1; -; Genomic_DNA.
DR EMBL; AL773585; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC120642; AAI20643.1; -; mRNA.
DR EMBL; BC120644; AAI20645.1; -; mRNA.
DR CCDS; CCDS16213.1; -.
DR RefSeq; NP_038756.2; NM_013728.2.
DR AlphaFoldDB; Q9QY00; -.
DR SMR; Q9QY00; -.
DR STRING; 10090.ENSMUSP00000097502; -.
DR GlyGen; Q9QY00; 1 site.
DR PaxDb; Q9QY00; -.
DR PRIDE; Q9QY00; -.
DR DNASU; 27216; -.
DR Ensembl; ENSMUST00000099918; ENSMUSP00000097502; ENSMUSG00000075212.
DR GeneID; 27216; -.
DR KEGG; mmu:27216; -.
DR UCSC; uc008kko.2; mouse.
DR CTD; 27216; -.
DR MGI; MGI:1351316; Olfr154.
DR VEuPathDB; HostDB:ENSMUSG00000075212; -.
DR eggNOG; ENOG502RF13; Eukaryota.
DR GeneTree; ENSGT01050000244931; -.
DR HOGENOM; CLU_012526_1_0_1; -.
DR InParanoid; Q9QY00; -.
DR OMA; ISISECA; -.
DR OrthoDB; 971463at2759; -.
DR PhylomeDB; Q9QY00; -.
DR TreeFam; TF352753; -.
DR BioGRID-ORCS; 27216; 0 hits in 44 CRISPR screens.
DR PRO; PR:Q9QY00; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; Q9QY00; protein.
DR Bgee; ENSMUSG00000075212; Expressed in olfactory epithelium.
DR Genevisible; Q9QY00; MM.
DR GO; GO:0016021; C:integral component of membrane; ISA:MGI.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0005549; F:odorant binding; IBA:GO_Central.
DR GO; GO:0004984; F:olfactory receptor activity; ISA:MGI.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; ISA:MGI.
DR GO; GO:0007608; P:sensory perception of smell; ISA:MGI.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Direct protein sequencing; Disulfide bond;
KW G-protein coupled receptor; Glycoprotein; Membrane; Olfaction; Receptor;
KW Reference proteome; Sensory transduction; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..318
FT /note="Olfactory receptor 154"
FT /id="PRO_0000150829"
FT TOPO_DOM 1..28
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 29..49
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 50..56
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 57..77
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 78..93
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 94..114
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 115..144
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 145..165
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 166..198
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 199..219
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 220..239
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 240..260
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 261..271
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 272..292
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 293..318
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 97..189
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT CONFLICT 154
FT /note="V -> I (in Ref. 1; AAF20365, 3; AAL61186/AAP71458
FT and 6; AAI20643/AAI20645)"
FT /evidence="ECO:0000305"
FT CONFLICT 195
FT /note="K -> N (in Ref. 1; AAF20365, 3; AAL61186/AAP71458
FT and 6; AAI20643/AAI20645)"
FT /evidence="ECO:0000305"
FT CONFLICT 313
FT /note="F -> L (in Ref. 1; AAF20365, 3; AAL61186 and 6;
FT AAI20643/AAI20645)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 318 AA; 35901 MW; C348CFAFAC8F880B CRC64;
MMHRNQTVVT EFFFTGLTSS FHLQIVLFLT FLCVYLATLL GNLGMIILIH LDTRLHIPMY
FFLSHLSFVD ACSSSVISPK MLSDMFVDKK VISFLGCAIQ LCLFSQFVVT ECFLLASMAY
DRYVAICKPL LYTLIMSQRV CVQLVIGPYS IGFVSTMVHI ISAFVLPYCG PNLINHFFCD
LLPVLSLACA NTQMKKRLLF IVAGILGVFS GIIILVSYVY IAITILKISS ADGRRKAFST
CSSHLTAVSI LYGTLFFIYV RPSSSFSLDI NKVVSLFYTT VIPMLNPFIY SLRNKEVKDA
LIRTFEKQFC YSFQDKIL
