OL181_MOUSE
ID OL181_MOUSE Reviewed; 317 AA.
AC Q8VGQ7; E9QKY8; Q05A60; Q7TS47;
DT 12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT 27-JUL-2011, sequence version 3.
DT 03-AUG-2022, entry version 133.
DE RecName: Full=Olfactory receptor 181;
DE AltName: Full=Olfactory receptor 184-4;
GN Name=Olfr181; Synonyms=Mor184-4;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=11802173; DOI=10.1038/nn800;
RA Zhang X., Firestein S.;
RT "The olfactory receptor gene superfamily of the mouse.";
RL Nat. Neurosci. 5:124-133(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=11875048; DOI=10.1093/hmg/11.5.535;
RA Young J.M., Friedman C., Williams E.M., Ross J.A., Tonnes-Priddy L.,
RA Trask B.J.;
RT "Different evolutionary processes shaped the mouse and human olfactory
RT receptor gene families.";
RL Hum. Mol. Genet. 11:535-546(2002).
RN [3]
RP ERRATUM OF PUBMED:11875048.
RA Young J.M., Friedman C., Williams E.M., Ross J.A., Tonnes-Priddy L.,
RA Trask B.J.;
RL Hum. Mol. Genet. 11:1683-1683(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Potential odorant receptor.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAP70774.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AY073089; AAL60752.1; -; Genomic_DNA.
DR EMBL; AY317266; AAP70774.1; ALT_INIT; Genomic_DNA.
DR EMBL; AC154545; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC125397; AAI25398.1; -; mRNA.
DR CCDS; CCDS28240.1; -.
DR RefSeq; NP_667210.2; NM_146999.2.
DR AlphaFoldDB; Q8VGQ7; -.
DR SMR; Q8VGQ7; -.
DR STRING; 10090.ENSMUSP00000074825; -.
DR GlyGen; Q8VGQ7; 1 site.
DR PaxDb; Q8VGQ7; -.
DR PRIDE; Q8VGQ7; -.
DR DNASU; 259001; -.
DR Ensembl; ENSMUST00000075361; ENSMUSP00000074825; ENSMUSG00000090951.
DR Ensembl; ENSMUST00000205742; ENSMUSP00000145806; ENSMUSG00000090951.
DR Ensembl; ENSMUST00000205986; ENSMUSP00000145877; ENSMUSG00000090951.
DR GeneID; 259001; -.
DR KEGG; mmu:259001; -.
DR UCSC; uc007zok.2; mouse.
DR CTD; 259001; -.
DR MGI; MGI:3030015; Olfr181.
DR VEuPathDB; HostDB:ENSMUSG00000090951; -.
DR eggNOG; KOG3656; Eukaryota.
DR GeneTree; ENSGT00950000182874; -.
DR HOGENOM; CLU_012526_5_5_1; -.
DR InParanoid; Q8VGQ7; -.
DR OMA; PYINEWI; -.
DR OrthoDB; 884649at2759; -.
DR PhylomeDB; Q8VGQ7; -.
DR TreeFam; TF352737; -.
DR BioGRID-ORCS; 259001; 1 hit in 63 CRISPR screens.
DR PRO; PR:Q8VGQ7; -.
DR Proteomes; UP000000589; Chromosome 16.
DR RNAct; Q8VGQ7; protein.
DR Bgee; ENSMUSG00000090951; Expressed in spermatid and 1 other tissue.
DR ExpressionAtlas; Q8VGQ7; differential.
DR GO; GO:0016021; C:integral component of membrane; ISA:MGI.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0005549; F:odorant binding; IBA:GO_Central.
DR GO; GO:0004984; F:olfactory receptor activity; ISA:MGI.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; ISA:MGI.
DR GO; GO:0007608; P:sensory perception of smell; ISA:MGI.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..317
FT /note="Olfactory receptor 181"
FT /id="PRO_0000269656"
FT TOPO_DOM 1..28
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 29..49
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 50..56
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 57..77
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 78..93
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 94..114
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 115..144
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 145..165
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 166..198
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 199..219
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 220..239
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 240..259
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 260..268
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 269..289
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 290..317
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 97..189
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT CONFLICT 134
FT /note="T -> S (in Ref. 1; AAL60752 and 2; AAP70774)"
FT /evidence="ECO:0000305"
FT CONFLICT 237
FT /note="A -> T (in Ref. 1; AAL60752, 2; AAP70774 and 5;
FT AAI25398)"
FT /evidence="ECO:0000305"
FT CONFLICT 272
FT /note="G -> D (in Ref. 1; AAL60752)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 317 AA; 36049 MW; 72DFBC7ABDB3886A CRC64;
MMKANHSLTV EFILIGFSDH TDLKTLLFLL FSAIYLVTIV GNLGLVALIY MEPRLHTPMY
IFLGNLALMD SCCSCAITPK MLENFFSVDR RISLYECMVQ FYFLCLAETA DCFLLAAMAY
DRYVAICNPL QYHTMMSKKL SIQMSIGTFI ASNLHSLIHT GCLLRLNFCK SRRIDHFFCD
ILPLYKLSCT DPFINELMLY IFSMPIQVFT ITTVLVSYSC ILLTVFKMKS KDGRGKAFST
CASHFFSVSI FYICLLMYIG PSKNSNKDIP VGVFYTIVIP LLNPFIYSLR NKEVVNAVKK
VMKTHSIFKN SSASIAH
