OL186_MOUSE
ID OL186_MOUSE Reviewed; 309 AA.
AC Q8VEX5;
DT 12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 03-AUG-2022, entry version 135.
DE RecName: Full=Olfactory receptor 186;
DE AltName: Full=Olfactory receptor 183-9;
GN Name=Olfr186; Synonyms=Mor183-9;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=11802173; DOI=10.1038/nn800;
RA Zhang X., Firestein S.;
RT "The olfactory receptor gene superfamily of the mouse.";
RL Nat. Neurosci. 5:124-133(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=11875048; DOI=10.1093/hmg/11.5.535;
RA Young J.M., Friedman C., Williams E.M., Ross J.A., Tonnes-Priddy L.,
RA Trask B.J.;
RT "Different evolutionary processes shaped the mouse and human olfactory
RT receptor gene families.";
RL Hum. Mol. Genet. 11:535-546(2002).
RN [3]
RP ERRATUM OF PUBMED:11875048.
RA Young J.M., Friedman C., Williams E.M., Ross J.A., Tonnes-Priddy L.,
RA Trask B.J.;
RL Hum. Mol. Genet. 11:1683-1683(2002).
CC -!- FUNCTION: Potential odorant receptor.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AY073772; AAL61435.1; -; Genomic_DNA.
DR EMBL; AY317271; AAP70776.1; -; Genomic_DNA.
DR CCDS; CCDS28242.1; -.
DR RefSeq; NP_666433.1; NM_146321.1.
DR AlphaFoldDB; Q8VEX5; -.
DR SMR; Q8VEX5; -.
DR STRING; 10090.ENSMUSP00000056448; -.
DR GlyGen; Q8VEX5; 2 sites.
DR PaxDb; Q8VEX5; -.
DR PRIDE; Q8VEX5; -.
DR DNASU; 258318; -.
DR Ensembl; ENSMUST00000062380; ENSMUSP00000056448; ENSMUSG00000047960.
DR Ensembl; ENSMUST00000206463; ENSMUSP00000146214; ENSMUSG00000047960.
DR Ensembl; ENSMUST00000216415; ENSMUSP00000150366; ENSMUSG00000047960.
DR GeneID; 258318; -.
DR KEGG; mmu:258318; -.
DR UCSC; uc007zom.1; mouse.
DR CTD; 258318; -.
DR MGI; MGI:3030020; Olfr186.
DR VEuPathDB; HostDB:ENSMUSG00000047960; -.
DR eggNOG; ENOG502T9JQ; Eukaryota.
DR GeneTree; ENSGT00950000182874; -.
DR HOGENOM; CLU_012526_8_1_1; -.
DR InParanoid; Q8VEX5; -.
DR OMA; MSLTECK; -.
DR OrthoDB; 865116at2759; -.
DR PhylomeDB; Q8VEX5; -.
DR TreeFam; TF352737; -.
DR BioGRID-ORCS; 258318; 4 hits in 65 CRISPR screens.
DR PRO; PR:Q8VEX5; -.
DR Proteomes; UP000000589; Chromosome 16.
DR RNAct; Q8VEX5; protein.
DR GO; GO:0016021; C:integral component of membrane; ISA:MGI.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0005549; F:odorant binding; IBA:GO_Central.
DR GO; GO:0004984; F:olfactory receptor activity; ISA:MGI.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; ISA:MGI.
DR GO; GO:0007608; P:sensory perception of smell; ISA:MGI.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..309
FT /note="Olfactory receptor 186"
FT /id="PRO_0000269658"
FT TOPO_DOM 1..28
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 29..49
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 50..56
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 57..77
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 78..93
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 94..114
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 115..144
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 145..165
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 166..198
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 199..219
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 220..239
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 240..260
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 261..271
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 272..292
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 293..309
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 186
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 97..189
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 309 AA; 34902 MW; 7F7F56B921B507AB CRC64;
MEDGNTTLLT EFVLTGLTDH QGLQVPLFLL FLMIYLITVV GNLGLIALIW SDPHLHIPMY
LFLGSLAFVD AWISSAVTPN MLFDLLSKNK MISLSECMIQ FFAFAFGGTT ECFLLGTMAY
DRYVAICKPL LYPVIMTNRL CIRLLVSVFI GGFLHSLFHV LFLLRLTFCN SNIIHHFYCD
IIPLYNISCT DPTLNLLLVF ILSGSIQVFT IMTVLVSYTL VLFTILKMKS LQGIRKAFST
CGAHLLSVSL YYGPLLFMYV LPASQQTDGQ GMMDSLFYTV IIPVLNPIIY SLRNKQVTDS
LKKRLERHV
