OL473_MOUSE
ID OL473_MOUSE Reviewed; 310 AA.
AC Q8VG44;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 03-AUG-2022, entry version 135.
DE RecName: Full=Olfactory receptor 473;
DE AltName: Full=Olfactory receptor 204-4;
GN Name=Olfr473; Synonyms=Mor204-4;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=11802173; DOI=10.1038/nn800;
RA Zhang X., Firestein S.;
RT "The olfactory receptor gene superfamily of the mouse.";
RL Nat. Neurosci. 5:124-133(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=11875048; DOI=10.1093/hmg/11.5.535;
RA Young J.M., Friedman C., Williams E.M., Ross J.A., Tonnes-Priddy L.,
RA Trask B.J.;
RT "Different evolutionary processes shaped the mouse and human olfactory
RT receptor gene families.";
RL Hum. Mol. Genet. 11:535-546(2002).
RN [3]
RP ERRATUM OF PUBMED:11875048.
RA Young J.M., Friedman C., Williams E.M., Ross J.A., Tonnes-Priddy L.,
RA Trask B.J.;
RL Hum. Mol. Genet. 11:1683-1683(2002).
CC -!- FUNCTION: Potential odorant receptor.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AY073319; AAL60982.1; -; Genomic_DNA.
DR EMBL; AY317581; AAP70978.1; -; Genomic_DNA.
DR CCDS; CCDS21696.1; -.
DR RefSeq; NP_666986.1; NM_146775.1.
DR AlphaFoldDB; Q8VG44; -.
DR SMR; Q8VG44; -.
DR STRING; 10090.ENSMUSP00000081816; -.
DR GlyGen; Q8VG44; 2 sites.
DR iPTMnet; Q8VG44; -.
DR PhosphoSitePlus; Q8VG44; -.
DR PaxDb; Q8VG44; -.
DR PRIDE; Q8VG44; -.
DR Ensembl; ENSMUST00000084761; ENSMUSP00000081816; ENSMUSG00000095212.
DR Ensembl; ENSMUST00000217618; ENSMUSP00000150610; ENSMUSG00000095212.
DR GeneID; 258771; -.
DR KEGG; mmu:258771; -.
DR UCSC; uc009jbp.1; mouse.
DR CTD; 258771; -.
DR MGI; MGI:3030307; Olfr473.
DR VEuPathDB; HostDB:ENSMUSG00000095212; -.
DR eggNOG; ENOG502SKA1; Eukaryota.
DR GeneTree; ENSGT01050000244860; -.
DR HOGENOM; CLU_012526_1_0_1; -.
DR InParanoid; Q8VG44; -.
DR OMA; ICSQLHT; -.
DR OrthoDB; 1013843at2759; -.
DR PhylomeDB; Q8VG44; -.
DR TreeFam; TF338848; -.
DR BioGRID-ORCS; 258771; 1 hit in 32 CRISPR screens.
DR PRO; PR:Q8VG44; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; Q8VG44; protein.
DR GO; GO:0030425; C:dendrite; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; ISA:MGI.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0045202; C:synapse; IEA:GOC.
DR GO; GO:0004993; F:G protein-coupled serotonin receptor activity; IBA:GO_Central.
DR GO; GO:0030594; F:neurotransmitter receptor activity; IBA:GO_Central.
DR GO; GO:0004984; F:olfactory receptor activity; ISA:MGI.
DR GO; GO:0007268; P:chemical synaptic transmission; IBA:GO_Central.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; ISA:MGI.
DR GO; GO:0007187; P:G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; IBA:GO_Central.
DR GO; GO:0007608; P:sensory perception of smell; ISA:MGI.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..310
FT /note="Olfactory receptor 473"
FT /id="PRO_0000150833"
FT TOPO_DOM 1..25
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 26..46
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 47..54
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 55..75
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 76..99
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 100..120
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 121..133
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 134..154
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 155..196
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 197..217
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 218..237
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 238..258
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 259..271
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 272..292
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 293..310
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 265
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 97..189
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 310 AA; 34187 MW; 307AE78DF6A736D1 CRC64;
MEAENHTTVA ELIILGLTED PKLCIVFFVI FLGVYIVTLV GNISIITLIR ISSQLHTPMY
LFLSHLAFVD ILYSTSVSVI MHMELLGHGL ALPVAACAAQ LCITVSFGSA ECFLLAAMAY
DRYVAICSPL LYSTLMSPRV CFLLLGMSYV GGCMNGWTFT GCLLSLSFCG PNQIDHFFCD
FSPLLKLSCS DVSIIGIIPS ISSGSIIVVT VFVIAVSYIY ILITILNMRS TEGRHKAFST
CTSHLTAVTL YYGTITFIYV MPKSNYSTEQ NKVLSVFYTV VIPMLNPLIY SLRNRDVKEA
LRKATVRVYS
