OL474_MOUSE
ID OL474_MOUSE Reviewed; 310 AA.
AC Q8VFC9;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 03-AUG-2022, entry version 127.
DE RecName: Full=Olfactory receptor 474;
DE AltName: Full=Olfactory receptor 204-20;
GN Name=Olfr474; Synonyms=Mor204-20;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=11802173; DOI=10.1038/nn800;
RA Zhang X., Firestein S.;
RT "The olfactory receptor gene superfamily of the mouse.";
RL Nat. Neurosci. 5:124-133(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=11875048; DOI=10.1093/hmg/11.5.535;
RA Young J.M., Friedman C., Williams E.M., Ross J.A., Tonnes-Priddy L.,
RA Trask B.J.;
RT "Different evolutionary processes shaped the mouse and human olfactory
RT receptor gene families.";
RL Hum. Mol. Genet. 11:535-546(2002).
RN [3]
RP ERRATUM OF PUBMED:11875048.
RA Young J.M., Friedman C., Williams E.M., Ross J.A., Tonnes-Priddy L.,
RA Trask B.J.;
RL Hum. Mol. Genet. 11:1683-1683(2002).
CC -!- FUNCTION: Potential odorant receptor.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AY073602; AAL61265.1; -; Genomic_DNA.
DR EMBL; AY317582; AAP70979.1; -; Genomic_DNA.
DR CCDS; CCDS21697.1; -.
DR RefSeq; NP_666706.1; NM_146495.1.
DR AlphaFoldDB; Q8VFC9; -.
DR SMR; Q8VFC9; -.
DR STRING; 10090.ENSMUSP00000055931; -.
DR GlyGen; Q8VFC9; 3 sites.
DR PaxDb; Q8VFC9; -.
DR PRIDE; Q8VFC9; -.
DR DNASU; 258488; -.
DR Ensembl; ENSMUST00000054434; ENSMUSP00000055931; ENSMUSG00000094197.
DR GeneID; 258488; -.
DR KEGG; mmu:258488; -.
DR UCSC; uc009jbq.1; mouse.
DR CTD; 258488; -.
DR MGI; MGI:3030308; Olfr474.
DR VEuPathDB; HostDB:ENSMUSG00000094197; -.
DR eggNOG; ENOG502SKA1; Eukaryota.
DR GeneTree; ENSGT01050000244860; -.
DR HOGENOM; CLU_012526_8_1_1; -.
DR InParanoid; Q8VFC9; -.
DR OMA; YVCIAHE; -.
DR OrthoDB; 1013843at2759; -.
DR PhylomeDB; Q8VFC9; -.
DR TreeFam; TF338848; -.
DR BioGRID-ORCS; 258488; 1 hit in 67 CRISPR screens.
DR PRO; PR:Q8VFC9; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; Q8VFC9; protein.
DR GO; GO:0030425; C:dendrite; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; ISA:MGI.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0045202; C:synapse; IEA:GOC.
DR GO; GO:0004993; F:G protein-coupled serotonin receptor activity; IBA:GO_Central.
DR GO; GO:0030594; F:neurotransmitter receptor activity; IBA:GO_Central.
DR GO; GO:0004984; F:olfactory receptor activity; ISA:MGI.
DR GO; GO:0007268; P:chemical synaptic transmission; IBA:GO_Central.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; ISA:MGI.
DR GO; GO:0007187; P:G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; IBA:GO_Central.
DR GO; GO:0007608; P:sensory perception of smell; ISA:MGI.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..310
FT /note="Olfactory receptor 474"
FT /id="PRO_0000150834"
FT TOPO_DOM 1..25
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 26..46
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 47..54
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 55..75
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 76..99
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 100..120
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 121..133
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 134..154
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 155..196
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 197..217
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 218..237
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 238..258
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 259..271
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 272..292
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 293..310
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 165
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 265
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 97..189
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 310 AA; 34423 MW; 4EF801D1DC9B4E93 CRC64;
MNGGNHTSMT ELFILGPTED PTFCIAFFVI FLGVYMVTLV GNISIITLIR ISSQLHTPVY
LFLNHLAFVD ILYSTLVSVI MLMELLEHEL ALPVAACAAE LCITVLFGSS ECFLLAAMAY
DCYVAICSPL LYSTLMSSRV CFLLLGMSYV GGCMNGWIFT GCLLNLSFYG PYQIDHFFCD
FSPLLKLSCS DVSIIGIIPS ISSGSIIVVT VLVIAVFYIC ILMTILKMHS TDGCHKAFST
CNSYLTAVTL YYGTITFIYV MPKSNYSTEK NKVLSEFYTV VIPMLNHLIY SLKNRDVKDA
LRKAIVRVYT
