OL476_MOUSE
ID OL476_MOUSE Reviewed; 310 AA.
AC Q8VGI4;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 03-AUG-2022, entry version 130.
DE RecName: Full=Olfactory receptor 476;
DE AltName: Full=Olfactory receptor 204-3;
GN Name=Olfr476; Synonyms=Mor204-3;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=11802173; DOI=10.1038/nn800;
RA Zhang X., Firestein S.;
RT "The olfactory receptor gene superfamily of the mouse.";
RL Nat. Neurosci. 5:124-133(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=11875048; DOI=10.1093/hmg/11.5.535;
RA Young J.M., Friedman C., Williams E.M., Ross J.A., Tonnes-Priddy L.,
RA Trask B.J.;
RT "Different evolutionary processes shaped the mouse and human olfactory
RT receptor gene families.";
RL Hum. Mol. Genet. 11:535-546(2002).
RN [3]
RP ERRATUM OF PUBMED:11875048.
RA Young J.M., Friedman C., Williams E.M., Ross J.A., Tonnes-Priddy L.,
RA Trask B.J.;
RL Hum. Mol. Genet. 11:1683-1683(2002).
CC -!- FUNCTION: Potential odorant receptor.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AY073164; AAL60827.1; -; Genomic_DNA.
DR EMBL; AY317584; AAP70980.1; -; Genomic_DNA.
DR CCDS; CCDS21698.1; -.
DR RefSeq; NP_667135.1; NM_146924.1.
DR AlphaFoldDB; Q8VGI4; -.
DR SMR; Q8VGI4; -.
DR STRING; 10090.ENSMUSP00000076485; -.
DR GlyGen; Q8VGI4; 2 sites.
DR PaxDb; Q8VGI4; -.
DR PRIDE; Q8VGI4; -.
DR Ensembl; ENSMUST00000077249; ENSMUSP00000076485; ENSMUSG00000095301.
DR Ensembl; ENSMUST00000217173; ENSMUSP00000149760; ENSMUSG00000095301.
DR GeneID; 258926; -.
DR KEGG; mmu:258926; -.
DR UCSC; uc009jbr.1; mouse.
DR CTD; 258926; -.
DR MGI; MGI:3030310; Olfr476.
DR VEuPathDB; HostDB:ENSMUSG00000095301; -.
DR eggNOG; ENOG502SKA1; Eukaryota.
DR GeneTree; ENSGT01050000244860; -.
DR HOGENOM; CLU_012526_1_0_1; -.
DR InParanoid; Q8VGI4; -.
DR OMA; NAGTFIS; -.
DR OrthoDB; 1013843at2759; -.
DR PhylomeDB; Q8VGI4; -.
DR TreeFam; TF338848; -.
DR BioGRID-ORCS; 258926; 0 hits in 33 CRISPR screens.
DR PRO; PR:Q8VGI4; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; Q8VGI4; protein.
DR Bgee; ENSMUSG00000095301; Expressed in epithelium and 15 other tissues.
DR GO; GO:0016021; C:integral component of membrane; ISA:MGI.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0005549; F:odorant binding; IBA:GO_Central.
DR GO; GO:0004984; F:olfactory receptor activity; ISA:MGI.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; ISA:MGI.
DR GO; GO:0007608; P:sensory perception of smell; ISA:MGI.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..310
FT /note="Olfactory receptor 476"
FT /id="PRO_0000150835"
FT TOPO_DOM 1..25
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 26..46
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 47..54
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 55..75
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 76..99
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 100..120
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 121..133
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 134..154
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 155..196
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 197..217
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 218..237
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 238..258
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 259..271
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 272..292
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 293..310
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 265
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 97..189
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 310 AA; 34193 MW; 3917333D02CA1CC1 CRC64;
METQNHTTVT EFILLGLTES STLRVILFMV FLGIYTVTLV GNFSIISLIR SCPQLHTPMY
LFLSHLAFVD IGFSTSITPT MFKGFLGNRL VLSVAACIAQ FCITVTFGTV ECFLLAVMAY
DRYVAICSPL LYSTHMSPRI CFLLVGASYV GGCVNSGAFT SCLSILSFCG PNQIDHFFCD
FPAVLKLSCS DVSIIGIIPS ISAGSIIVIT VFVIAVSYAY ILITILKMRS TEGRQKAFST
CTSHLTAVTL YYGTITFIYV MPKSNYSTAQ NKILSVFYTV VIPMLNPLIY SLRNRDVKEA
LRKAIIRIFP
