OL480_MOUSE
ID OL480_MOUSE Reviewed; 312 AA.
AC Q8VEZ0; Q9WU91;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 03-AUG-2022, entry version 138.
DE RecName: Full=Olfactory receptor 480;
DE AltName: Full=Odorant receptor S25;
DE AltName: Full=Olfactory receptor 204-32;
GN Name=Olfr480; Synonyms=Mor204-32;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=BALB/cJ;
RX PubMed=10089886; DOI=10.1016/s0092-8674(00)80581-4;
RA Malnic B., Hirono J., Sato T., Buck L.B.;
RT "Combinatorial receptor codes for odors.";
RL Cell 96:713-723(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RX PubMed=11802173; DOI=10.1038/nn800;
RA Zhang X., Firestein S.;
RT "The olfactory receptor gene superfamily of the mouse.";
RL Nat. Neurosci. 5:124-133(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=11875048; DOI=10.1093/hmg/11.5.535;
RA Young J.M., Friedman C., Williams E.M., Ross J.A., Tonnes-Priddy L.,
RA Trask B.J.;
RT "Different evolutionary processes shaped the mouse and human olfactory
RT receptor gene families.";
RL Hum. Mol. Genet. 11:535-546(2002).
RN [4]
RP ERRATUM OF PUBMED:11875048.
RA Young J.M., Friedman C., Williams E.M., Ross J.A., Tonnes-Priddy L.,
RA Trask B.J.;
RL Hum. Mol. Genet. 11:1683-1683(2002).
CC -!- FUNCTION: Probable odorant receptor, which recognizes only aliphatic
CC alcohols, suggesting that it may convey a 'woody' or 'sweet' sour.
CC {ECO:0000269|PubMed:11802173}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAD27597.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AF121977; AAD27597.1; ALT_INIT; Genomic_DNA.
DR EMBL; AY073753; AAL61416.1; -; Genomic_DNA.
DR EMBL; AY317588; AAP70984.1; -; Genomic_DNA.
DR CCDS; CCDS21702.2; -.
DR RefSeq; NP_064687.1; NM_020291.1.
DR AlphaFoldDB; Q8VEZ0; -.
DR SMR; Q8VEZ0; -.
DR STRING; 10090.ENSMUSP00000071583; -.
DR GlyGen; Q8VEZ0; 2 sites.
DR PaxDb; Q8VEZ0; -.
DR PRIDE; Q8VEZ0; -.
DR DNASU; 56861; -.
DR Ensembl; ENSMUST00000217653; ENSMUSP00000149301; ENSMUSG00000063120.
DR GeneID; 56861; -.
DR KEGG; mmu:56861; -.
DR UCSC; uc009jbv.1; mouse.
DR CTD; 56861; -.
DR MGI; MGI:3030314; Olfr480.
DR VEuPathDB; HostDB:ENSMUSG00000063120; -.
DR eggNOG; ENOG502SKA1; Eukaryota.
DR GeneTree; ENSGT01050000244860; -.
DR InParanoid; Q8VEZ0; -.
DR OrthoDB; 1002838at2759; -.
DR PhylomeDB; Q8VEZ0; -.
DR TreeFam; TF352753; -.
DR BioGRID-ORCS; 56861; 1 hit in 33 CRISPR screens.
DR PRO; PR:Q8VEZ0; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; Q8VEZ0; protein.
DR Bgee; ENSMUSG00000063120; Expressed in lumbar subsegment of spinal cord and 16 other tissues.
DR ExpressionAtlas; Q8VEZ0; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; ISA:MGI.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0005549; F:odorant binding; IBA:GO_Central.
DR GO; GO:0004984; F:olfactory receptor activity; ISA:MGI.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; ISA:MGI.
DR GO; GO:0007608; P:sensory perception of smell; ISA:MGI.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..312
FT /note="Olfactory receptor 480"
FT /id="PRO_0000150838"
FT TOPO_DOM 1..25
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 26..46
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 47..54
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 55..75
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 76..99
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 100..120
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 121..133
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 134..154
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 155..196
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 197..217
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 218..237
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 238..258
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 259..271
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 272..292
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 293..312
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 165
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 97..189
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 312 AA; 34729 MW; 4C0E4AEBE7100251 CRC64;
MEPGNYTVVT EFILLGLTDD ITVSVILFVM FLIVYSVTLM GNLNIIVLIR TSPQLHTPMY
LFLSHLAFLD IGYSSSVTPI MLRGFLRKGT FIPVAGCVAQ LCIVVAFGTS ESFLLASMAY
DRYVAICSPL LYSTQMSSTV CILLVGTSYL GGWVNAWIFT GCSLNLSFCG PNKINHFFCD
YSPLLKLSCS HDFSFEVIPA ISSGSIIVVT VFIIALSYVY ILVSILKMRS TEGRQKAFST
CTSHLTAVTL FFGTITFIYV MPQSSYSTDQ NKVVSVFYTV VIPMLNPLIY SFRNKEVKEA
MKKLIAKTHW WS
