OL484_MOUSE
ID OL484_MOUSE Reviewed; 321 AA.
AC Q8VFD3;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 03-AUG-2022, entry version 139.
DE RecName: Full=Olfactory receptor 484;
DE AltName: Full=Olfactory receptor 204-16;
GN Name=Olfr484; Synonyms=Mor204-16;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=11802173; DOI=10.1038/nn800;
RA Zhang X., Firestein S.;
RT "The olfactory receptor gene superfamily of the mouse.";
RL Nat. Neurosci. 5:124-133(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=11875048; DOI=10.1093/hmg/11.5.535;
RA Young J.M., Friedman C., Williams E.M., Ross J.A., Tonnes-Priddy L.,
RA Trask B.J.;
RT "Different evolutionary processes shaped the mouse and human olfactory
RT receptor gene families.";
RL Hum. Mol. Genet. 11:535-546(2002).
RN [3]
RP ERRATUM OF PUBMED:11875048.
RA Young J.M., Friedman C., Williams E.M., Ross J.A., Tonnes-Priddy L.,
RA Trask B.J.;
RL Hum. Mol. Genet. 11:1683-1683(2002).
CC -!- FUNCTION: Potential odorant receptor.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AY073598; AAL61261.1; -; Genomic_DNA.
DR EMBL; AY317592; AAP70988.1; -; Genomic_DNA.
DR CCDS; CCDS21706.1; -.
DR RefSeq; NP_666710.1; NM_146499.1.
DR AlphaFoldDB; Q8VFD3; -.
DR SMR; Q8VFD3; -.
DR STRING; 10090.ENSMUSP00000073267; -.
DR GlyGen; Q8VFD3; 1 site.
DR PaxDb; Q8VFD3; -.
DR PRIDE; Q8VFD3; -.
DR Ensembl; ENSMUST00000210881; ENSMUSP00000147263; ENSMUSG00000110171.
DR Ensembl; ENSMUST00000214722; ENSMUSP00000150774; ENSMUSG00000110171.
DR GeneID; 258492; -.
DR KEGG; mmu:258492; -.
DR UCSC; uc009jbz.1; mouse.
DR CTD; 258492; -.
DR MGI; MGI:3030318; Olfr484.
DR VEuPathDB; HostDB:ENSMUSG00000110171; -.
DR eggNOG; ENOG502SKA1; Eukaryota.
DR GeneTree; ENSGT01050000244860; -.
DR HOGENOM; CLU_012526_1_0_1; -.
DR InParanoid; Q8VFD3; -.
DR OMA; GCINSWI; -.
DR OrthoDB; 999769at2759; -.
DR PhylomeDB; Q8VFD3; -.
DR TreeFam; TF338848; -.
DR BioGRID-ORCS; 258492; 2 hits in 33 CRISPR screens.
DR PRO; PR:Q8VFD3; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; Q8VFD3; protein.
DR Bgee; ENSMUSG00000110171; Expressed in proximal tubule.
DR ExpressionAtlas; Q8VFD3; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; ISA:MGI.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0005549; F:odorant binding; IBA:GO_Central.
DR GO; GO:0004984; F:olfactory receptor activity; ISA:MGI.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; ISA:MGI.
DR GO; GO:0007608; P:sensory perception of smell; ISA:MGI.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..321
FT /note="Olfactory receptor 484"
FT /id="PRO_0000150842"
FT TOPO_DOM 1..28
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 29..49
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 50..57
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 58..78
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 79..102
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 103..123
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 124..136
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 137..157
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 158..199
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 200..220
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 221..240
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 241..261
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 262..274
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 275..295
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 296..321
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 8
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 100..192
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 321 AA; 35724 MW; 262CDEA4EEBA8A46 CRC64;
MAFLHNGNHT AVTEFILLGL TDDPVLRIVL FTIILCIYLV TVSGNLSTIL LIRVSSQLHH
PMYFFLSHLA SADIGYSSSV TPNMLVNFLV KQNTISYIGC SIQFGSAAFF GGLECFLLAV
MAYDRFVAIC NPLLYSTKMS TQVCVQLVVG SYIGGFLNAS FATVSFLFLF FCGPNIINHF
FCDFAPLIEL SCSDVRISVL VTSFSAGTVT MLTVLVIAIS YTYILITILK MRSTEGRHKA
FSTCTSHLTA VSLFYGTITF IYVMPKSRYS TDQNKVVSVF YMVVIPMLNP LIYSLRNNEI
KGALRRHLGK KIFSQSNILF Y
