OL488_MOUSE
ID OL488_MOUSE Reviewed; 314 AA.
AC Q8VG02;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 03-AUG-2022, entry version 135.
DE RecName: Full=Olfactory receptor 488;
DE AltName: Full=Olfactory receptor 204-15;
GN Name=Olfr488; Synonyms=Mor204-15;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=11802173; DOI=10.1038/nn800;
RA Zhang X., Firestein S.;
RT "The olfactory receptor gene superfamily of the mouse.";
RL Nat. Neurosci. 5:124-133(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=11875048; DOI=10.1093/hmg/11.5.535;
RA Young J.M., Friedman C., Williams E.M., Ross J.A., Tonnes-Priddy L.,
RA Trask B.J.;
RT "Different evolutionary processes shaped the mouse and human olfactory
RT receptor gene families.";
RL Hum. Mol. Genet. 11:535-546(2002).
RN [3]
RP ERRATUM OF PUBMED:11875048.
RA Young J.M., Friedman C., Williams E.M., Ross J.A., Tonnes-Priddy L.,
RA Trask B.J.;
RL Hum. Mol. Genet. 11:1683-1683(2002).
CC -!- FUNCTION: Potential odorant receptor.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AY073363; AAL61026.1; -; Genomic_DNA.
DR EMBL; AY317596; AAP70992.1; -; Genomic_DNA.
DR CCDS; CCDS21709.1; -.
DR RefSeq; NP_666943.1; NM_146732.1.
DR AlphaFoldDB; Q8VG02; -.
DR SMR; Q8VG02; -.
DR STRING; 10090.ENSMUSP00000072735; -.
DR GlyGen; Q8VG02; 1 site.
DR PaxDb; Q8VG02; -.
DR PRIDE; Q8VG02; -.
DR Ensembl; ENSMUST00000072968; ENSMUSP00000072735; ENSMUSG00000096465.
DR Ensembl; ENSMUST00000211508; ENSMUSP00000147652; ENSMUSG00000096465.
DR Ensembl; ENSMUST00000215173; ENSMUSP00000149427; ENSMUSG00000096465.
DR GeneID; 258727; -.
DR KEGG; mmu:258727; -.
DR UCSC; uc009jcd.1; mouse.
DR CTD; 258727; -.
DR MGI; MGI:3030322; Olfr488.
DR VEuPathDB; HostDB:ENSMUSG00000096465; -.
DR eggNOG; ENOG502SKA1; Eukaryota.
DR GeneTree; ENSGT01050000244860; -.
DR HOGENOM; CLU_012526_1_0_1; -.
DR InParanoid; Q8VG02; -.
DR OMA; ITYVYIL; -.
DR OrthoDB; 999769at2759; -.
DR PhylomeDB; Q8VG02; -.
DR TreeFam; TF338848; -.
DR BioGRID-ORCS; 258727; 2 hits in 66 CRISPR screens.
DR PRO; PR:Q8VG02; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; Q8VG02; protein.
DR GO; GO:0016021; C:integral component of membrane; ISA:MGI.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0005549; F:odorant binding; IBA:GO_Central.
DR GO; GO:0004984; F:olfactory receptor activity; ISA:MGI.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; ISA:MGI.
DR GO; GO:0007608; P:sensory perception of smell; ISA:MGI.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..314
FT /note="Olfactory receptor 488"
FT /id="PRO_0000150844"
FT TOPO_DOM 1..28
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 29..49
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 50..57
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 58..78
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 79..102
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 103..123
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 124..136
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 137..157
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 158..199
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 200..220
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 221..240
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 241..261
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 262..274
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 275..295
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 296..314
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 8
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 100..192
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 314 AA; 35125 MW; 6D55A7B1EB41689C CRC64;
MAFLDNGNHT AVTEFILLGL TDDPFLRIVL FSIILCIYLV TVFGNLSTIL LIRVSSQLHH
PMYFFLSHLA TVDLGISSSV TPSMLVNFLA ERSTISYLGC GIQLSSAALF GTLECFLLAV
MAYDRFMAIC NPLLYSTKLS TRFCIQLVVG SYIGAFLNDS CYILSFAFFL FCGPNKVDHF
FCDLSPMMEL SCSDASVSGV VISFTAGSIT MTTLIVIVIS YFYILITILK MRSTEGRQKA
FSTCTSHLTA VTLYYGTIIF IYVMPKSTYS RDQNKVVSLF YMVVIPMLNP LIYSLRNNEI
KGALKKQFYR KTLL
