OL491_MOUSE
ID OL491_MOUSE Reviewed; 310 AA.
AC Q8VG06;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 03-AUG-2022, entry version 126.
DE RecName: Full=Olfactory receptor 491;
DE AltName: Full=Olfactory receptor 204-11;
GN Name=Olfr491; Synonyms=Mor204-11;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=11802173; DOI=10.1038/nn800;
RA Zhang X., Firestein S.;
RT "The olfactory receptor gene superfamily of the mouse.";
RL Nat. Neurosci. 5:124-133(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=11875048; DOI=10.1093/hmg/11.5.535;
RA Young J.M., Friedman C., Williams E.M., Ross J.A., Tonnes-Priddy L.,
RA Trask B.J.;
RT "Different evolutionary processes shaped the mouse and human olfactory
RT receptor gene families.";
RL Hum. Mol. Genet. 11:535-546(2002).
RN [3]
RP ERRATUM OF PUBMED:11875048.
RA Young J.M., Friedman C., Williams E.M., Ross J.A., Tonnes-Priddy L.,
RA Trask B.J.;
RL Hum. Mol. Genet. 11:1683-1683(2002).
CC -!- FUNCTION: Potential odorant receptor.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AY073359; AAL61022.1; -; Genomic_DNA.
DR EMBL; AY317599; AAP70994.1; -; Genomic_DNA.
DR CCDS; CCDS21711.1; -.
DR RefSeq; NP_666947.1; NM_146736.1.
DR AlphaFoldDB; Q8VG06; -.
DR SMR; Q8VG06; -.
DR STRING; 10090.ENSMUSP00000061188; -.
DR GlyGen; Q8VG06; 1 site.
DR PaxDb; Q8VG06; -.
DR PRIDE; Q8VG06; -.
DR DNASU; 258731; -.
DR Ensembl; ENSMUST00000053179; ENSMUSP00000061188; ENSMUSG00000094612.
DR Ensembl; ENSMUST00000209545; ENSMUSP00000148094; ENSMUSG00000094612.
DR Ensembl; ENSMUST00000214605; ENSMUSP00000150694; ENSMUSG00000094612.
DR GeneID; 258731; -.
DR KEGG; mmu:258731; -.
DR UCSC; uc009jcf.1; mouse.
DR CTD; 258731; -.
DR MGI; MGI:3030325; Olfr491.
DR VEuPathDB; HostDB:ENSMUSG00000094612; -.
DR eggNOG; ENOG502SKA1; Eukaryota.
DR GeneTree; ENSGT01050000244860; -.
DR HOGENOM; CLU_012526_1_0_1; -.
DR InParanoid; Q8VG06; -.
DR OMA; CSQLQTP; -.
DR OrthoDB; 1013843at2759; -.
DR PhylomeDB; Q8VG06; -.
DR TreeFam; TF338848; -.
DR BioGRID-ORCS; 258731; 1 hit in 65 CRISPR screens.
DR PRO; PR:Q8VG06; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; Q8VG06; protein.
DR GO; GO:0016021; C:integral component of membrane; ISA:MGI.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0005549; F:odorant binding; IBA:GO_Central.
DR GO; GO:0004984; F:olfactory receptor activity; ISA:MGI.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; ISA:MGI.
DR GO; GO:0007608; P:sensory perception of smell; ISA:MGI.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..310
FT /note="Olfactory receptor 491"
FT /id="PRO_0000150846"
FT TOPO_DOM 1..25
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 26..46
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 47..54
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 55..75
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 76..99
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 100..120
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 121..133
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 134..154
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 155..196
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 197..217
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 218..237
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 238..258
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 259..271
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 272..292
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 293..310
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 97..189
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 310 AA; 34193 MW; 79D7AC9CDD65FBD8 CRC64;
MEPGNHTAVT KFILLGLTDD PTLCVIFFVF FLGIYIVTLV GNISIINLVR SCPQLQTPMY
MFLSHLAFVD IGYSTSVTPI MLIGFIVHET GLPVHACEAQ LCSVVTFGTA ECFLLAAMAY
DRYVAICSPL LYSTHMSSQI CLLLVGASYV GGCVNAWTFT GCLLSLSFCG PNKIDHFFCD
FSPLLKLSCS DVSIIGIIPS ISAGSIIVVT VFVISVSYIY ILITILKMRS TEGRHKAFST
CTSHLTAVTL YYGTITFIYV MPKSSYSTKQ NRVVSLFYTV VIPMLNPLIY SLRNRDVKEA
LRKATLRIYS
