OL495_MOUSE
ID OL495_MOUSE Reviewed; 330 AA.
AC Q8VF12;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 03-AUG-2022, entry version 132.
DE RecName: Full=Olfactory receptor 495;
DE AltName: Full=Olfactory receptor 204-37;
GN Name=Olfr495; Synonyms=Mor204-37;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=11802173; DOI=10.1038/nn800;
RA Zhang X., Firestein S.;
RT "The olfactory receptor gene superfamily of the mouse.";
RL Nat. Neurosci. 5:124-133(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=11875048; DOI=10.1093/hmg/11.5.535;
RA Young J.M., Friedman C., Williams E.M., Ross J.A., Tonnes-Priddy L.,
RA Trask B.J.;
RT "Different evolutionary processes shaped the mouse and human olfactory
RT receptor gene families.";
RL Hum. Mol. Genet. 11:535-546(2002).
RN [3]
RP ERRATUM OF PUBMED:11875048.
RA Young J.M., Friedman C., Williams E.M., Ross J.A., Tonnes-Priddy L.,
RA Trask B.J.;
RL Hum. Mol. Genet. 11:1683-1683(2002).
CC -!- FUNCTION: Potential odorant receptor.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AY073729; AAL61392.1; -; Genomic_DNA.
DR EMBL; AY317603; AAP70998.1; -; Genomic_DNA.
DR CCDS; CCDS21714.1; -.
DR RefSeq; NP_666476.1; NM_146364.1.
DR AlphaFoldDB; Q8VF12; -.
DR SMR; Q8VF12; -.
DR STRING; 10090.ENSMUSP00000071440; -.
DR GlyGen; Q8VF12; 1 site.
DR PaxDb; Q8VF12; -.
DR PRIDE; Q8VF12; -.
DR DNASU; 258361; -.
DR Ensembl; ENSMUST00000210990; ENSMUSP00000147501; ENSMUSG00000110253.
DR Ensembl; ENSMUST00000215215; ENSMUSP00000150689; ENSMUSG00000110253.
DR GeneID; 258361; -.
DR KEGG; mmu:258361; -.
DR UCSC; uc009jcj.1; mouse.
DR CTD; 258361; -.
DR MGI; MGI:3030329; Olfr495.
DR VEuPathDB; HostDB:ENSMUSG00000110253; -.
DR eggNOG; ENOG502SKA1; Eukaryota.
DR GeneTree; ENSGT01050000244860; -.
DR HOGENOM; CLU_012526_1_0_1; -.
DR InParanoid; Q8VF12; -.
DR OMA; RRIMIFK; -.
DR OrthoDB; 999769at2759; -.
DR PhylomeDB; Q8VF12; -.
DR TreeFam; TF338848; -.
DR BioGRID-ORCS; 258361; 0 hits in 34 CRISPR screens.
DR ChiTaRS; Olfr495; mouse.
DR PRO; PR:Q8VF12; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; Q8VF12; protein.
DR GO; GO:0016021; C:integral component of membrane; ISA:MGI.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0005549; F:odorant binding; IBA:GO_Central.
DR GO; GO:0004984; F:olfactory receptor activity; ISA:MGI.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; ISA:MGI.
DR GO; GO:0007608; P:sensory perception of smell; ISA:MGI.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..330
FT /note="Olfactory receptor 495"
FT /id="PRO_0000150850"
FT TOPO_DOM 1..28
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 29..49
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 50..57
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 58..78
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 79..102
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 103..123
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 124..136
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 137..157
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 158..199
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 200..220
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 221..240
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 241..261
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 262..274
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 275..295
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 296..330
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 8
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 100..192
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 330 AA; 36873 MW; 8E68CDCE67F964B8 CRC64;
MAFLEDGNHT IVTEFILLGL TDDPVLRDIL FTIILCIYLV TVSGNLSTIL LIRVSSQLHH
PMYFFLSHLA SVDIGISSSV TPNMLANFLV KPNTISYIGC SIQFTSAVFL ATVECFLLAA
MAYDRFVAIC NPLLYSTKMS REACIQLVVG SYIQGLLNAS FFTLSFFSLI FCGPNRINHF
YCDLAPLVEL SCSDVTLAVV ITSISAGFIT LTTVFVIAIS YSCIFITIMK MHSTESRYKA
FSTCTSHLTA VTLFYGTTMF IYVMPKSSYS TDQNKVLSVF YMVVIPMLNP LIYSLRNNEI
KGALKRYLGK KIFSYGNLFC KTHYNDTHQV
