OL498_MOUSE
ID OL498_MOUSE Reviewed; 330 AA.
AC Q8VEW2;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 25-MAY-2022, entry version 126.
DE RecName: Full=Olfactory receptor 498;
DE AltName: Full=Olfactory receptor 204-36;
GN Name=Olfr498; Synonyms=Mor204-36;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=11802173; DOI=10.1038/nn800;
RA Zhang X., Firestein S.;
RT "The olfactory receptor gene superfamily of the mouse.";
RL Nat. Neurosci. 5:124-133(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=11875048; DOI=10.1093/hmg/11.5.535;
RA Young J.M., Friedman C., Williams E.M., Ross J.A., Tonnes-Priddy L.,
RA Trask B.J.;
RT "Different evolutionary processes shaped the mouse and human olfactory
RT receptor gene families.";
RL Hum. Mol. Genet. 11:535-546(2002).
RN [3]
RP ERRATUM OF PUBMED:11875048.
RA Young J.M., Friedman C., Williams E.M., Ross J.A., Tonnes-Priddy L.,
RA Trask B.J.;
RL Hum. Mol. Genet. 11:1683-1683(2002).
CC -!- FUNCTION: Potential odorant receptor.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AY073786; AAL61449.1; -; Genomic_DNA.
DR EMBL; AY317606; AAP71000.1; -; Genomic_DNA.
DR CCDS; CCDS21716.1; -.
DR RefSeq; NP_666419.2; NM_146307.2.
DR AlphaFoldDB; Q8VEW2; -.
DR SMR; Q8VEW2; -.
DR STRING; 10090.ENSMUSP00000074343; -.
DR GlyGen; Q8VEW2; 1 site.
DR iPTMnet; Q8VEW2; -.
DR PhosphoSitePlus; Q8VEW2; -.
DR PaxDb; Q8VEW2; -.
DR PRIDE; Q8VEW2; -.
DR ProteomicsDB; 293505; -.
DR GeneID; 258304; -.
DR KEGG; mmu:258304; -.
DR UCSC; uc009jcl.1; mouse.
DR CTD; 258304; -.
DR MGI; MGI:3030332; Olfr498.
DR eggNOG; ENOG502SKA1; Eukaryota.
DR InParanoid; Q8VEW2; -.
DR OrthoDB; 999769at2759; -.
DR PhylomeDB; Q8VEW2; -.
DR TreeFam; TF338848; -.
DR BioGRID-ORCS; 258304; 2 hits in 61 CRISPR screens.
DR PRO; PR:Q8VEW2; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; Q8VEW2; protein.
DR GO; GO:0016021; C:integral component of membrane; ISA:MGI.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0005549; F:odorant binding; IBA:GO_Central.
DR GO; GO:0004984; F:olfactory receptor activity; ISA:MGI.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; ISA:MGI.
DR GO; GO:0007608; P:sensory perception of smell; ISA:MGI.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..330
FT /note="Olfactory receptor 498"
FT /id="PRO_0000150852"
FT TOPO_DOM 1..28
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 29..49
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 50..57
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 58..78
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 79..102
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 103..123
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 124..136
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 137..157
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 158..199
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 200..220
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 221..240
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 241..261
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 262..274
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 275..295
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 296..330
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 8
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 100..192
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT CONFLICT 16
FT /note="I -> F (in Ref. 2; AAP71000)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 330 AA; 36854 MW; 8C60A83B91046083 CRC64;
MAFLEDGNHT TVTEFILLGL TDDPVLRDIL FIIILCIYLV TVSGNLSTIL LIRVSSQLHH
PMYFILSHLA SVDIGISSSV TPNMLATFLV KQNTISYIGC SIQFTSAAFF GTVECFLLAT
MAYDRFVAIC NPLLYSTKMS TEACIQLVVG SYIQGFLNAS FFTLSFFSLF FCGPNRINDF
YCDFAPLLEL SCSDVTVAVV ITSISAGFIT LTTVFVIAIS YSCIFITIMK MHSTESRCKA
FSTCTSHLTA VILFYGTAIF IYVMPKSSYS TDQNKVLSIF YTVVIPMLNP LIYSLRNNEI
KEALKRHLGK KVFSYGNLFC KTHYNHNYPV
