OL502_MOUSE
ID OL502_MOUSE Reviewed; 314 AA.
AC Q8VG09; Q0VBE2;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 03-AUG-2022, entry version 136.
DE RecName: Full=Olfactory receptor 502;
DE AltName: Full=Olfactory receptor 204-8;
GN Name=Olfr502; Synonyms=Mor204-8;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=11802173; DOI=10.1038/nn800;
RA Zhang X., Firestein S.;
RT "The olfactory receptor gene superfamily of the mouse.";
RL Nat. Neurosci. 5:124-133(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=11875048; DOI=10.1093/hmg/11.5.535;
RA Young J.M., Friedman C., Williams E.M., Ross J.A., Tonnes-Priddy L.,
RA Trask B.J.;
RT "Different evolutionary processes shaped the mouse and human olfactory
RT receptor gene families.";
RL Hum. Mol. Genet. 11:535-546(2002).
RN [3]
RP ERRATUM OF PUBMED:11875048.
RA Young J.M., Friedman C., Williams E.M., Ross J.A., Tonnes-Priddy L.,
RA Trask B.J.;
RL Hum. Mol. Genet. 11:1683-1683(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Potential odorant receptor.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AY073356; AAL61019.1; -; Genomic_DNA.
DR EMBL; AY317610; AAP71001.1; -; Genomic_DNA.
DR EMBL; BC119235; AAI19236.1; -; mRNA.
DR EMBL; BC120678; AAI20679.1; -; mRNA.
DR CCDS; CCDS21717.1; -.
DR RefSeq; NP_666950.1; NM_146739.1.
DR AlphaFoldDB; Q8VG09; -.
DR SMR; Q8VG09; -.
DR STRING; 10090.ENSMUSP00000077963; -.
DR GlyGen; Q8VG09; 1 site.
DR PaxDb; Q8VG09; -.
DR PRIDE; Q8VG09; -.
DR Ensembl; ENSMUST00000078933; ENSMUSP00000077963; ENSMUSG00000058014.
DR Ensembl; ENSMUST00000216919; ENSMUSP00000151167; ENSMUSG00000058014.
DR GeneID; 258734; -.
DR KEGG; mmu:258734; -.
DR UCSC; uc009jcm.1; mouse.
DR CTD; 258734; -.
DR MGI; MGI:3030336; Olfr502.
DR VEuPathDB; HostDB:ENSMUSG00000058014; -.
DR eggNOG; ENOG502SKA1; Eukaryota.
DR GeneTree; ENSGT01050000244860; -.
DR HOGENOM; CLU_012526_1_0_1; -.
DR InParanoid; Q8VG09; -.
DR OMA; MHFTEGR; -.
DR OrthoDB; 999769at2759; -.
DR PhylomeDB; Q8VG09; -.
DR TreeFam; TF338848; -.
DR BioGRID-ORCS; 258734; 2 hits in 66 CRISPR screens.
DR PRO; PR:Q8VG09; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; Q8VG09; protein.
DR GO; GO:0016021; C:integral component of membrane; ISA:MGI.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0005549; F:odorant binding; IBA:GO_Central.
DR GO; GO:0004984; F:olfactory receptor activity; ISA:MGI.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; ISA:MGI.
DR GO; GO:0007608; P:sensory perception of smell; ISA:MGI.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..314
FT /note="Olfactory receptor 502"
FT /id="PRO_0000150853"
FT TOPO_DOM 1..28
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 29..49
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 50..57
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 58..78
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 79..102
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 103..123
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 124..136
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 137..157
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 158..199
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 200..220
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 221..240
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 241..261
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 262..274
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 275..295
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 296..314
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 8
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 100..192
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 314 AA; 34550 MW; E143B2A1E0321BD9 CRC64;
MAFLEDGNHT AVTGFILLGL TDDPVLRVVL FVIILCIYLV TVSGNLSTIL LIRVSSQLHH
PMYFFLSHLA SADIGYSSSV TPNMLVNFLV ERNTISYLGC GIQLGSAVFF GTVECFLLAA
MAYDRFIAIC SPLLYSNKMS TQVCVQLLVG SYIGGFLNAS SFTLSFFSLV FCGPNRVNHF
FCDFAPLVKL SCSDVSVPAV VPSFTAGSII IVTIFVIAVS YIYILITILK MRSTEGRQKA
FSTCTSHLTA VTLFYGTITF IYVMPKSSYS TDQNKVVSVF YMVVVPMLNP LIYSLRNKEI
KGALKRQLAK NTFS
