OL508_MOUSE
ID OL508_MOUSE Reviewed; 310 AA.
AC Q8VG42;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 03-AUG-2022, entry version 132.
DE RecName: Full=Olfactory receptor 508;
DE AltName: Full=Olfactory receptor 204-6;
GN Name=Olfr508; Synonyms=Mor204-6;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=11802173; DOI=10.1038/nn800;
RA Zhang X., Firestein S.;
RT "The olfactory receptor gene superfamily of the mouse.";
RL Nat. Neurosci. 5:124-133(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=11875048; DOI=10.1093/hmg/11.5.535;
RA Young J.M., Friedman C., Williams E.M., Ross J.A., Tonnes-Priddy L.,
RA Trask B.J.;
RT "Different evolutionary processes shaped the mouse and human olfactory
RT receptor gene families.";
RL Hum. Mol. Genet. 11:535-546(2002).
RN [3]
RP ERRATUM OF PUBMED:11875048.
RA Young J.M., Friedman C., Williams E.M., Ross J.A., Tonnes-Priddy L.,
RA Trask B.J.;
RL Hum. Mol. Genet. 11:1683-1683(2002).
CC -!- FUNCTION: Potential odorant receptor.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AY073321; AAL60984.1; -; Genomic_DNA.
DR EMBL; AY317616; AAP71006.1; -; Genomic_DNA.
DR CCDS; CCDS21722.1; -.
DR RefSeq; NP_666984.1; NM_146773.1.
DR AlphaFoldDB; Q8VG42; -.
DR SMR; Q8VG42; -.
DR STRING; 10090.ENSMUSP00000072686; -.
DR GlyGen; Q8VG42; 2 sites.
DR PaxDb; Q8VG42; -.
DR PRIDE; Q8VG42; -.
DR Ensembl; ENSMUST00000072914; ENSMUSP00000072686; ENSMUSG00000063764.
DR GeneID; 258769; -.
DR KEGG; mmu:258769; -.
DR UCSC; uc009jcr.1; mouse.
DR CTD; 258769; -.
DR MGI; MGI:3030342; Olfr508.
DR VEuPathDB; HostDB:ENSMUSG00000063764; -.
DR eggNOG; ENOG502SKA1; Eukaryota.
DR GeneTree; ENSGT01050000244860; -.
DR HOGENOM; CLU_012526_1_0_1; -.
DR InParanoid; Q8VG42; -.
DR OMA; LACSHDF; -.
DR OrthoDB; 1002838at2759; -.
DR PhylomeDB; Q8VG42; -.
DR TreeFam; TF338848; -.
DR Reactome; R-MMU-381753; Olfactory Signaling Pathway.
DR BioGRID-ORCS; 258769; 5 hits in 66 CRISPR screens.
DR PRO; PR:Q8VG42; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; Q8VG42; protein.
DR GO; GO:0016021; C:integral component of membrane; ISA:MGI.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0005549; F:odorant binding; IBA:GO_Central.
DR GO; GO:0004984; F:olfactory receptor activity; ISA:MGI.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; ISA:MGI.
DR GO; GO:0007608; P:sensory perception of smell; ISA:MGI.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..310
FT /note="Olfactory receptor 508"
FT /id="PRO_0000150855"
FT TOPO_DOM 1..25
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 26..46
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 47..54
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 55..75
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 76..99
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 100..120
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 121..133
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 134..154
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 155..196
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 197..217
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 218..237
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 238..258
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 259..271
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 272..292
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 293..310
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 165
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 97..189
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 310 AA; 34360 MW; 65137FF45BB761B0 CRC64;
MEPGNYTVVT EVILLGFTED AIIRAILFIV FLIIYSVTLM GNASIIMLIR RSPQLHTPMY
LLLSHLAFVD IGYSSSVTPI MLKGFLRKET FILVSGCVAQ LCSVVTFGST ECFLLAAMAY
DRYVAICSPL LYATQMSSTV CILLVGASYL GGCVNAWTFT GCLLNLSFCR PNKVNHFFCD
YSPLLKISCS HDFSSEVIPA ISSGSIIVVT VFIIALSYVY ILVSILKMRS TEGRQKAFST
CTSHLTAVTL FYGTITFIYV MPKSSYSTDQ NKVVSVFYTV VIPMLNPIIY SLRNKDVKEA
MKKLMANTHH
