OL688_MOUSE
ID OL688_MOUSE Reviewed; 321 AA.
AC Q6W049; E9PVA1;
DT 28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT 28-JUN-2011, sequence version 2.
DT 03-AUG-2022, entry version 121.
DE RecName: Full=Olfactory receptor 688 {ECO:0000312|EMBL:AAS99798.1};
GN Name=Olfr688 {ECO:0000312|EMBL:AAS99798.1, ECO:0000312|MGI:MGI:3030522};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1] {ECO:0000312|EMBL:AAS99798.1}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=14611657; DOI=10.1186/gb-2003-4-11-r71;
RA Young J.M., Shykind B.M., Lane R.P., Tonnes-Priddy L., Ross J.A.,
RA Walker M., Williams E.M., Trask B.J.;
RT "Odorant receptor expressed sequence tags demonstrate olfactory expression
RT of over 400 genes, extensive alternate splicing and unequal expression
RT levels.";
RL Genome Biol. 4:R71.1-R71.13(2003).
RN [2] {ECO:0000312|Ensembl:ENSMUSP00000095758}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
CC -!- FUNCTION: Odorant receptor. {ECO:0000303|PubMed:14611657, ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAS99798.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AY317809; AAS99798.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AC122523; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS52348.1; -.
DR RefSeq; NP_001011533.2; NM_001011533.2.
DR AlphaFoldDB; Q6W049; -.
DR SMR; Q6W049; -.
DR STRING; 10090.ENSMUSP00000095758; -.
DR iPTMnet; Q6W049; -.
DR PhosphoSitePlus; Q6W049; -.
DR PaxDb; Q6W049; -.
DR PRIDE; Q6W049; -.
DR Ensembl; ENSMUST00000098155; ENSMUSP00000095758; ENSMUSG00000073909.
DR GeneID; 259161; -.
DR KEGG; mmu:259161; -.
DR UCSC; uc009ixt.1; mouse.
DR CTD; 259161; -.
DR MGI; MGI:3030522; Olfr688.
DR VEuPathDB; HostDB:ENSMUSG00000073909; -.
DR eggNOG; ENOG502SJUD; Eukaryota.
DR GeneTree; ENSGT01050000244929; -.
DR HOGENOM; CLU_012526_0_0_1; -.
DR InParanoid; Q6W049; -.
DR OMA; HETMLHE; -.
DR OrthoDB; 1012273at2759; -.
DR PhylomeDB; Q6W049; -.
DR TreeFam; TF344049; -.
DR BioGRID-ORCS; 259161; 2 hits in 61 CRISPR screens.
DR PRO; PR:Q6W049; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; Q6W049; protein.
DR GO; GO:0016021; C:integral component of membrane; ISA:MGI.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; ISA:MGI.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; ISA:MGI.
DR GO; GO:0007608; P:sensory perception of smell; ISA:MGI.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Membrane;
KW Olfaction; Receptor; Reference proteome; Sensory transduction; Transducer;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..321
FT /note="Olfactory receptor 688"
FT /id="PRO_0000409662"
FT TOPO_DOM 1..36
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 37..57
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 58..70
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 71..91
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 92..105
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 106..126
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 127..128
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 129..149
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 150..207
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 208..228
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 229..250
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 251..271
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 272..275
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 276..296
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 297..321
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DISULFID 103..185
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 321 AA; 35690 MW; 7F78CE71316DB465 CRC64;
MGTALHETNS SEVHVSEFIL LGFPGIHEFQ IWLSLPMALL YIVALGANLL ILITIYLEPT
LHQPMYQFLG ILAAVDIGLA TTSMPKILAI LWFDAKTISL PECFAQIYAI HTFMCMESGV
FLCMAIDRYV AICYPLQYPS IVTEAFVIKA TLSMLLRNGL LTIPVPVLAA QRQYCSRNEI
DHCLCSNLGV ISLACDDITV NRFYQLALAW LVVGSDMILV YASYALIIRS VLRLNSTEAA
SKALSTCSSH LILIMFYYTA IVIVSVTHLA GRRVPLIPVL LNVMHIVIPP SLNPVVYALR
TQELKVGFRK VFSLSEFVSR K
