OL998_MOUSE
ID OL998_MOUSE Reviewed; 314 AA.
AC Q8VF76; A2ALC8;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 27-JUL-2011, sequence version 2.
DT 03-AUG-2022, entry version 139.
DE RecName: Full=Olfactory receptor 998;
DE AltName: Full=Olfactory receptor 175-5;
GN Name=Olfr998; Synonyms=Mor175-5;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=11802173; DOI=10.1038/nn800;
RA Zhang X., Firestein S.;
RT "The olfactory receptor gene superfamily of the mouse.";
RL Nat. Neurosci. 5:124-133(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=11875048; DOI=10.1093/hmg/11.5.535;
RA Young J.M., Friedman C., Williams E.M., Ross J.A., Tonnes-Priddy L.,
RA Trask B.J.;
RT "Different evolutionary processes shaped the mouse and human olfactory
RT receptor gene families.";
RL Hum. Mol. Genet. 11:535-546(2002).
RN [3]
RP ERRATUM OF PUBMED:11875048.
RA Young J.M., Friedman C., Williams E.M., Ross J.A., Tonnes-Priddy L.,
RA Trask B.J.;
RL Hum. Mol. Genet. 11:1683-1683(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
CC -!- FUNCTION: Potential odorant receptor.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AY073662; AAL61325.1; -; Genomic_DNA.
DR EMBL; AY318192; AAP71455.1; -; Genomic_DNA.
DR EMBL; AL773585; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS16210.1; -.
DR RefSeq; NP_666647.2; NM_146436.2.
DR AlphaFoldDB; Q8VF76; -.
DR SMR; Q8VF76; -.
DR STRING; 10090.ENSMUSP00000059970; -.
DR GlyGen; Q8VF76; 1 site.
DR PaxDb; Q8VF76; -.
DR PRIDE; Q8VF76; -.
DR Ensembl; ENSMUST00000052307; ENSMUSP00000059970; ENSMUSG00000111454.
DR Ensembl; ENSMUST00000215083; ENSMUSP00000150713; ENSMUSG00000111454.
DR GeneID; 258428; -.
DR KEGG; mmu:258428; -.
DR UCSC; uc008kkl.2; mouse.
DR CTD; 258428; -.
DR MGI; MGI:3030832; Olfr998.
DR VEuPathDB; HostDB:ENSMUSG00000111454; -.
DR eggNOG; ENOG502RF13; Eukaryota.
DR GeneTree; ENSGT01050000244931; -.
DR HOGENOM; CLU_012526_1_0_1; -.
DR InParanoid; Q8VF76; -.
DR OMA; AGPYAMA; -.
DR OrthoDB; 971463at2759; -.
DR PhylomeDB; Q8VF76; -.
DR TreeFam; TF352753; -.
DR BioGRID-ORCS; 258428; 4 hits in 65 CRISPR screens.
DR PRO; PR:Q8VF76; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; Q8VF76; protein.
DR GO; GO:0016021; C:integral component of membrane; ISA:MGI.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0005549; F:odorant binding; IBA:GO_Central.
DR GO; GO:0004984; F:olfactory receptor activity; ISA:MGI.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; ISA:MGI.
DR GO; GO:0007608; P:sensory perception of smell; ISA:MGI.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..314
FT /note="Olfactory receptor 998"
FT /id="PRO_0000150857"
FT TOPO_DOM 1..25
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 26..46
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 47..54
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 55..75
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 76..99
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 100..120
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 121..133
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 134..154
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 155..196
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 197..217
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 218..237
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 238..258
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 259..271
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 272..292
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 293..312
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 97..189
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT CONFLICT 246
FT /note="S -> A (in Ref. 1; AAL61325 and 2; AAP71455)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 314 AA; 35374 MW; 675289C82B1FBEED CRC64;
MEEKNQTIVM EFFFLGLTDH LYQKIALFIT ILFVYLVTLG GNLGMITLIW ADPRLHTPMY
FFLSHLSFVD MCSSSSIAPK MLCDIFAEEK RISFMGCAAQ MWFFGFFVGT ECFLLASMAY
DRYTAICKPL LYTLLMSQRV CVHLVVGPYV FAIINITTHT TLAFCLPFCG SNTINHFFCD
VSPLLSLACA DSWVNKVVLF VLSGAIGVFS GLIIIVSYVS ILMTIFKIQT ADGKQKAFST
CSSHLSAVSI LYGTLFFIYV RPSASFSLNI NKMISLFYTV VIPMLNPLIY SLRNKEVKGA
FRRKVQKKHF PAGR
